DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pkp2 and p120ctn

DIOPT Version :9

Sequence 1:	NP_001106904.1	Gene:	pkp2 / 568060	ZFINID:	ZDB-GENE-041210-167	Length:	815	Species:	Danio rerio
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	207/767 - (26%)
Similarity:	358/767 - (46%)	Gaps:	139/767 - (18%)

- Green bases have known domain annotations that are detailed below.

Zfish   107 SLGSLHLKRTFSVNHEATRSLRMVDRSQWPSME--PPLFHRGYGSFRYTPKRAGLCLGSNSLTLP 169
            ::.|.|:....|:.||....     :||:.|.:  ......||.|   ||.......|..::| .
  Fly    14 NMNSTHINMDLSLTHEPANM-----QSQFGSFQNYDQFSAAGYSS---TPLYITKPTGVGAIT-K 69

Zfish   170 SAPTTSHFQMNKLPLRYAHS---EVLRNPRFAGLSAATQIPSSPVYENPHTDDTDDVFLPSTSVE 231
            .||   |...||:......:   ::..:|    |:...:...:..||     ||.:..:...:.
  Fly    70 VAP---HCSQNKIETNSTDNSIPDIENHP----LATTVRYVQAGQYE-----DTSEYGVAGLTC- 121

Zfish   232 RGRMESEKHTLQQTL--CKQREGGFVALEQ-------------SENVSW-------QSRVRKPSL 274
              .::|| :|.:..:  |...:..:..::.             ::|::.       |.|..|.|.
  Fly   122 --GIDSE-YTAEAVVPYCYTSDANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSA 183

Zfish   275 EFVAGRRPSQTGSLISMEEQSGSLGRIEKLEVKQHAVTTLTKKGKPGELSAEM-----TLKEAVN 334
            ||   :.|....|.|:...|        :||.|...:     :|...::.:.|     .|.|.::
  Fly   184 EF---KLPQFAMSSINTVPQ--------RLEEKDDYI-----EGSENDICSTMRWRDPNLSEVIS 232

Zfish   335 LLTQDNNMETQIAAANFIQNQCFNSPDAKRKILHLQGIPKLLKLMQNDSEELQWAAVSSLRNIVF 399
            .|:..::.....||| ::|:.|:.....|::...|.|||.|::|:..||.|:...|..:|||:.:
  Fly   233 FLSNPSSAIKANAAA-YLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSY 296

Zfish   400 --ENNENKMEVKDCEGLPVILRLLKINRDIETRRQLTGLLWNLSSHDLLKEHLSREAVKPLTDSV 462
              :|:|||..:|:..|:..::.||..:::.|.:..:||:|||:||.:.||..:..||:..:..||
  Fly   297 GRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSV 361

Zfish   463 LVPCSG---ISEGEDPKLELLADPDIFYNATGCLRNLSSAGPDGRKVMRDCEGLIECVIYYIRGT 524
            :.|.||   :..||      .....:|.||:|.|||:||||...|..:|:||.|:||::|.:|.:
  Fly   362 IKPHSGWDAVCCGE------TCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTS 420

Zfish   525 IADYKPDDKATENCVCILHNLSYRFDCEVPRVDSPVAQK-----PKQTHTETS---NPGCFIIKT 581
            |......:|..|||||||.|||||  |:  .||.|...|     |::....:|   |.|||....
  Fly   421 IEKNNIGNKTVENCVCILRNLSYR--CQ--EVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNK 481

Zfish   582 PKNSAENLEADEDY--------PALEENGSPHGVEWLWSAITVRMYLSLIAVSTNQHTKQASIGT 638
            .|..|.|.:|..:|        .::..|....|.|.||....|:.||||:...:|..|.:|:.|.
  Fly   482 KKKEANNSDALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGA 546

Zfish   639 LQNLTACSGEISQAIAHFIVQKEGGLSQVKKLLQ-EAEKEELRISVSLLKNIS---RYRELHADI 699
            :|||:||..:.|..| ...|:||.||..:.:||: |.::....::.: |:|::   |.:||   |
  Fly   547 IQNLSACYWQPSIDI-RATVRKEKGLPILVELLRMEVDRVVCAVATA-LRNLAIDQRNKEL---I 606

Zfish   700 VKQVLPELVAILPNS----DRNVEQPIEITVTICHILINLSQASASN---TCAIINQGALPKIIS 757
            .|..:.:||..||:.    |:|....     ||..:|..:::....|   :.::::.|.:.::::
  Fly   607 GKYAMRDLVQKLPSGNVQHDQNTSDD-----TITAVLATINEVIKKNPEFSRSLLDSGGIDRLMN 666

Zfish   758 ISSKDNGFGPTRAGQAACVL------LHTLWRHSELHSSFKKAGYRKTDFIN 803
            |:.:...:       .:|||      |:|:|:|:||...:||.|:::.||::
  Fly   667 ITKRKEKY-------TSCVLKFASQVLYTMWQHNELRDVYKKNGWKEQDFVS 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pkp2	NP_001106904.1	ARM	326..442	CDD:237987	37/122 (30%)
		armadillo repeat	329..355	CDD:293788	7/25 (28%)
		armadillo repeat	363..399	CDD:293788	14/35 (40%)
		armadillo repeat	405..440	CDD:293788	10/34 (29%)
		armadillo repeat	455..496	CDD:293788	13/43 (30%)
		armadillo repeat	657..689	CDD:293788	9/32 (28%)
		ARM	658..763	CDD:237987	27/115 (23%)
		armadillo repeat	696..737	CDD:293788	11/44 (25%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	36/114 (32%)
		armadillo repeat	227..252	CDD:293788	7/25 (28%)
		armadillo repeat	260..296	CDD:293788	14/35 (40%)
		armadillo repeat	304..339	CDD:293788	10/34 (29%)
		ARM	307..442	CDD:237987	53/140 (38%)
		armadillo repeat	347..392	CDD:293788	15/50 (30%)
		armadillo repeat	515..556	CDD:293788	17/40 (43%)
		ARM	516..643	CDD:237987	43/136 (32%)
		armadillo repeat	562..596	CDD:293788	9/34 (26%)
		armadillo repeat	601..641	CDD:293788	14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583611
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.800