DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PSG11 and Ceacam1

DIOPT Version :9

Sequence 1:	NP_002776.3	Gene:	PSG11 / 5680	HGNCID:	9516	Length:	335	Species:	Homo sapiens
Sequence 2:	NP_001029032.1	Gene:	Ceacam1 / 81613	RGDID:	67396	Length:	519	Species:	Rattus norvegicus

Alignment Length:	323	Identity:	144/323 - (44%)
Similarity:	183/323 - (56%)	Gaps:	2/323 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    13 IKWKGLLLTALLLNFWNLPTTAQVMIEAQPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYH 77
            |.|:||||||.||.:|:..|||||.::|.||.|.|.|.||||.|||||....:.||||...:...
  Rat    13 IPWRGLLLTASLLTYWSPLTTAQVTVDAVPPNVVEEKSVLLLAHNLPQEFQVFYWYKGTTLNPDS 77

Human    78 YITSYVVDGQIIIYGPAYSGRETVYSNASLLIQNVTREDAGSYTLHIIKRGDGTRGVTGYFTFTL 142
            .|..|:....:...|||||||||:|||.||..|||.:.|..:|||.:..:  ....:.....|.:
  Rat    78 EIARYIRSDNMSKTGPAYSGRETIYSNGSLFFQNVNKTDERAYTLSVFDQ--QFNPIQTSVQFRV 140

Human   143 YLETPKPSISSSNLNPREAMETVILTCNPETPDASYLWWMNGQSLPMTHRMQLSETNRTLFLFGV 207
            |....||:::.:|.||.|....|.|.|.|.|.:.||||..||:||....|:..||.||||.|..|
  Rat   141 YPALQKPNVTGNNSNPMEGEPFVSLMCEPYTNNTSYLWSRNGESLSEGDRVTFSEGNRTLTLLNV 205

Human   208 TKYTAGPYECEIWNSGSASRSDPVTLNLLHGPDLPRIFPSVTSYYSGENLDLSCFANSNPPAQYS 272
            .:...|.||||..|..:.:||||..|::::|||.|.|.|.....:.|.||:|||.|:|||||||.
  Rat   206 RRTDKGYYECEARNPATFNRSDPFNLDVIYGPDAPVISPPDIYLHQGSNLNLSCHADSNPPAQYF 270

Human   273 WTINGKFQLSGQKLFIPQITPKHNGLYACSARNSATGEESSTSLTIRVIAPPGLGTFAFNNPT 335
            |.||.|.|.|.|:|||..||..::|.|||...|:.||...:|...|.|..|....:....|.|
  Rat   271 WLINEKLQTSSQELFISNITTNNSGTYACFVNNTVTGLSRTTVKNITVFEPVTQPSIQITNTT 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSG11	NP_002776.3	Ig_CEACAM_D1	36..138	CDD:143251	43/101 (43%)
		IG_like	45..>121	CDD:214653	36/75 (48%)
		Cell attachment site. /evidence=ECO:0000255	127..129		0/1 (0%)
		Ig	148..236	CDD:299845	39/87 (45%)
		IG_like	163..223	CDD:214653	28/59 (47%)
		Ig_2	242..320	CDD:290606	38/77 (49%)
		IG_like	246..318	CDD:214653	35/71 (49%)
Ceacam1	NP_001029032.1	Ig_CEACAM_D1	36..140	CDD:143251	44/105 (42%)
		Required for homophilic binding. /evidence=ECO:0000269\|PubMed:8831574	39..142		43/104 (41%)
		Ig	146..233	CDD:299845	39/86 (45%)
		IG_like	157..233	CDD:214653	34/75 (45%)
		Ig_2	240..318	CDD:290606	38/77 (49%)
		IG_like	244..318	CDD:214653	36/73 (49%)
		Ig	320..410	CDD:299845	3/14 (21%)
		IG_like	331..410	CDD:214653	2/3 (67%)
		Interaction with calmodulin. /evidence=ECO:0000269\|PubMed:8576129	445..457
		Interaction with FLNA. /evidence=ECO:0000269\|PubMed:16291724	447..519
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..519
		Required for interaction with PTPN11 and PTPN6 and for control of phosphorylation level. /evidence=ECO:0000250\|UniProtKB:P31809	484..519
		Essential for interaction with PTPN11 and PTPN6. /evidence=ECO:0000250\|UniProtKB:P31809	513..516
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83688876
Domainoid	1	1.000	89	1.000	Domainoid score	I45148
eggNOG	1	0.900	-	-		E1_29WEF
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125478at9347
OrthoFinder	1	1.000	-	-		FOG0000658
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750