DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PSG11 and Ceacam1

DIOPT Version :9

Sequence 1:	NP_002776.3	Gene:	PSG11 / 5680	HGNCID:	9516	Length:	335	Species:	Homo sapiens
Sequence 2:	NP_001034274.1	Gene:	Ceacam1 / 26365	MGIID:	1347245	Length:	521	Species:	Mus musculus

Alignment Length:	313	Identity:	149/313 - (47%)
Similarity:	190/313 - (60%)	Gaps:	4/313 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    13 IKWKGLLLTALLLNFWNLPTTAQVMIEAQPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYH 77
            :.|.||||||.||..|:..|||:|.|||.||:|:|..:|||||||||..|..:.||||....:..
Mouse    13 VPWGGLLLTASLLASWSPATTAEVTIEAVPPQVAEDNNVLLLVHNLPLALGAFAWYKGNTTAIDK 77

Human    78 YITSYVVDGQIIIYGPAYSGRETVYSNASLLIQNVTREDAGSYTLHIIKRGDGTRGVTGYFTFTL 142
            .|..:|.:..:...|.||||||.:|||.|||.|.:|.:|.|.|||.:  ..:..|.......|.:
Mouse    78 EIARFVPNSNMNFTGQAYSGREIIYSNGSLLFQMITMKDMGVYTLDM--TDENYRRTQATVRFHV 140

Human   143 YLETPKPSISSSNLNPREAMETVILTCNPET-PD-ASYLWWMNGQSLPMTHRMQLSETNRTLFLF 205
            :....||:|:|:|.||.|..::|.|||:..| || .:|||..||:||....|::|||.||||.|.
Mouse   141 HPILLKPNITSNNSNPVEGDDSVSLTCDSYTDPDNINYLWSRNGESLSEGDRLKLSEGNRTLTLL 205

Human   206 GVTKYTAGPYECEIWNSGSASRSDPVTLNLLHGPDLPRIFPSVTSYYSGENLDLSCFANSNPPAQ 270
            .||:...|||.||..|..|.:||||.:||:::|||.|.|.||....:.|.||:|||.|.||||||
Mouse   206 NVTRNDTGPYVCETRNPVSVNRSDPFSLNIIYGPDTPIISPSDIYLHPGSNLNLSCHAASNPPAQ 270

Human   271 YSWTINGKFQLSGQKLFIPQITPKHNGLYACSARNSATGEESSTSLTIRVIAP 323
            |.|.||.|...|.|:||||.||..::|.|.|...||.||...:|...|.|:.|
Mouse   271 YFWLINEKPHASSQELFIPNITTNNSGTYTCFVNNSVTGLSRTTVKNITVLEP 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSG11	NP_002776.3	Ig_CEACAM_D1	36..138	CDD:143251	45/101 (45%)
		IG_like	45..>121	CDD:214653	35/75 (47%)
		Cell attachment site. /evidence=ECO:0000255	127..129		0/1 (0%)
		Ig	148..236	CDD:299845	46/89 (52%)
		IG_like	163..223	CDD:214653	31/61 (51%)
		Ig_2	242..320	CDD:290606	39/77 (51%)
		IG_like	246..318	CDD:214653	36/71 (51%)
Ceacam1	NP_001034274.1	Ig_CEACAM_D1	36..140	CDD:143251	46/105 (44%)
		Required for homophilic binding. /evidence=ECO:0000250\|UniProtKB:P16573	39..142		44/104 (42%)
		Ig	146..235	CDD:299845	45/88 (51%)
		IG_like	157..221	CDD:214653	31/63 (49%)
		Ig_2	242..320	CDD:290606	39/77 (51%)
		IG_like	246..320	CDD:214653	37/73 (51%)
		IG_like	333..406	CDD:214653
		IGc2	340..401	CDD:197706
		TM_EphA1	416..452	CDD:214014
		Interaction with calmodulin. /evidence=ECO:0000250\|UniProtKB:P16573	445..457
		Interaction with FLNA. /evidence=ECO:0000250\|UniProtKB:P16573	447..521
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..521
		Required for interaction with PTPN11 and PTPN6 and for control of phosphorylation level. /evidence=ECO:0000269\|PubMed:9867848	484..521
		Essential for interaction with PTPN11 and PTPN6. /evidence=ECO:0000269\|PubMed:9867848	515..518
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83965297
Domainoid	1	1.000	55	1.000	Domainoid score	I56226
eggNOG	1	0.900	-	-		E1_29WEF
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125478at9347
OrthoFinder	1	1.000	-	-		FOG0000658
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750