DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PSG11 and ncam-1

DIOPT Version :9

Sequence 1:	NP_002776.3	Gene:	PSG11 / 5680	HGNCID:	9516	Length:	335	Species:	Homo sapiens
Sequence 2:	NP_741709.1	Gene:	ncam-1 / 180418	WormBaseID:	WBGene00017184	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	332	Identity:	77/332 - (23%)
Similarity:	125/332 - (37%)	Gaps:	71/332 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    19 LLTALLLNFWNL---PTTAQVMIEAQPPKVSEGKDVLLLVHNLPQNLTGYI------WYKGQIRD 74
            ||..|:|:.|.|   ||..::       :.....|..|:|..: ::..|..      ||:
Worm    38 LLLLLILSGWTLSLSPTEERL-------QNRRSGDNFLVVCKV-KDFDGAASDAKIEWYR----- 89

Human    75 LYHYITSYVVDGQIIIYGPAYSGRETV---YSNASLLIQNVTREDAGSYTLHIIKRGDGTRGVTG 136
                      ||::|   |.:....|:   ||| .|:|......|.|.||.....:|: .:.|:.
Worm    90 ----------DGKLI---PRFGSTMTIERTYSN-QLMINRPKISDGGKYTCKTEIQGE-QQEVSA 139

Human   137 YFTFTLYLETPKPSISSSNLNPREAMETVILTCNPE-TPDASYLWWMNGQSLPMTHR--MQLSET 198
            ..:|   ::.||......:.:|.|.....|: |..| |......|..||.:|..|.:  .:.||.
Worm   140 EISF---VDPPKFLNVQESQHPEEGTRAEIV-CEVEGTDQLEVFWQFNGVTLDETSQRGYEFSEN 200

Human   199 NRTLFLFGVTKYTA----GPYECEIWNSGSASRSDPVTLNLLHGPDLPRI----FPSVTSYYSGE 255
            |:.|:   :..:||    |.|.|   |:...|..:.:::|:. |...|.|    .|:......|.
Worm   201 NQILY---IPHFTAKKDDGIYNC---NAAQYSSFETLSVNVT-GYARPTITVFDVPNGNRGIEGH 258

Human   256 NLDLSCFANSNPPAQYSWTI---------NGKFQLSGQKLFIPQITPKHNGLYACSARNSATGEE 311
            .::|.|.|...|...|.|..         :.|..:....|.|..:..:..|.|.|.|.|:....|
Worm   259 TIELKCGAVGKPKPTYKWFFEDDEVPIARSDKHNVEEGLLIIESLNSEDAGTYKCVANNTVGSNE 323

Human   312 SSTSLTI 318
            .:..|.:
Worm   324 RTFDLAV 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSG11	NP_002776.3	Ig_CEACAM_D1	36..138	CDD:143251	22/110 (20%)
		IG_like	45..>121	CDD:214653	18/84 (21%)
		Cell attachment site. /evidence=ECO:0000255	127..129		0/1 (0%)
		Ig	148..236	CDD:299845	24/94 (26%)
		IG_like	163..223	CDD:214653	19/66 (29%)
		Ig_2	242..320	CDD:290606	20/90 (22%)
		IG_like	246..318	CDD:214653	18/80 (23%)
ncam-1	NP_741709.1	IG	64..142	CDD:214652	22/98 (22%)
		Ig	69..140	CDD:143165	20/91 (22%)
		IG_like	153..236	CDD:214653	23/89 (26%)
		Ig	160..222	CDD:299845	19/68 (28%)
		IG_like	256..330	CDD:214653	17/73 (23%)
		IGc2	256..320	CDD:197706	15/63 (24%)
		IG_like	<445..499	CDD:214653
		Ig	<445..498	CDD:143165
		IG_like	520..596	CDD:214653
		IGc2	520..587	CDD:197706
		FN3	<652..701	CDD:238020
		FN3	<817..873	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910