DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PSG9 and ceacam8l

DIOPT Version :9

Sequence 1:	XP_016882493.1	Gene:	PSG9 / 5678	HGNCID:	9526	Length:	495	Species:	Homo sapiens
Sequence 2:	XP_031761715.1	Gene:	ceacam8l / 101730286	XenbaseID:	XB-GENE-22169429	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	419	Identity:	102/419 - (24%)
Similarity:	153/419 - (36%)	Gaps:	107/419 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     9 CTQRITWKGLLLTASLLNFWNPPTTAEVTIEAQPPKVSEGKDVLLLVHNLPQNLPGYFWYKGEMT 73
            |...:|....:|..||..:.:......|.:..|.|.||:  .|.|.|..:...:..:.||||...
Frog     4 CRHLLTQCCWMLAVSLSAWMDGAHGIGVQLIPQYPVVSQ--SVTLSVTGVTGTIRQFSWYKGSSA 66

Human    74 DLYHYIISYIVDGKIIIYGPAYSGRETVYSNASLLIQNVTRKDAGTYTLHIIKRGDETREEIRHF 138
            |..:.|.|.|.....:..||.|..|.....|.||.|..:...|.|.||:.:......|::.:
Frog    67 DTNNQIFSVIPSANSVTKGPQYFPRANWLPNGSLQISGLVPTDQGNYTVLMYTAESTTQDTV--- 128

Human   139 TFTLYLETPKPYISSSNLNPREAMEAVRLICDPETLDASYLWWMNGQSLPVTHRLQLSKTNRTLY 203
                                                           ||||
Frog   129 -----------------------------------------------SLPV-------------- 132

Human   204 LFGVTKYIAGPYECEIRNPVSASRSDPVTLNLLPKLPIPYITINNLNPRENKDVLAFTCEPKSEN 268
                       ||     |||:|.                |:.:|..|:||:.| ..||...:..
Frog   133 -----------YE-----PVSSSG----------------ISTDNKEPQENQPV-TLTCSANNAE 164

Human   269 YTYIWWLNGQSLPVSPGVKRPIENRILILPSVTRNETGPYQCEIRDRYGGLRSNPVILNVLYGPD 333
             ..:|..||  :|:.||:....:||.|..|.::|::||.|:||..:....:.|:|..|.|.|||:
Frog   165 -QILWSKNG--VPLPPGLTLSADNRTLTFPRISRSDTGQYRCEASNAVSKIISDPYTLTVNYGPE 226

Human   334 LPRIYPSFTYYRSGENLDLSCFTESNPPAEYFWTING-KFQQSGQKLFIPQITRNHSGLYACSVH 397
            ..:|..:. ...||.:..|.|..:|.|...|.|..|| ..:.....|:|.|.|...:|.|.|...
Frog   227 NLKIKGTL-QVTSGYSTSLECSADSVPAPTYQWKFNGTNLESQTNTLYIQQATPESAGNYTCIGT 290

Human   398 NSATGKEISKSMTVKVS-GKWIPASLAVG 425
            ||.|  ::|:..:|.|| ..:.|:...:|
Frog   291 NSVT--KLSRETSVYVSVNDYNPSDNPIG 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSG9	XP_016882493.1	Ig_CEACAM_D1	36..133	CDD:143251	29/96 (30%)
		IG_like	45..>121	CDD:214653	23/75 (31%)
		Ig	148..236	CDD:299845	10/87 (11%)
		Ig	242..329	CDD:299845	27/86 (31%)
		IG_like	260..322	CDD:214653	18/61 (30%)
		Ig_2	335..413	CDD:290606	23/78 (29%)
		IG_like	339..413	CDD:214653	22/74 (30%)
ceacam8l	XP_031761715.1	Ig	29..132	CDD:416386	31/154 (20%)
		FR1	30..48	CDD:409353	7/19 (37%)
		Ig strand A	30..32	CDD:409353	0/1 (0%)
		Ig strand A'	37..39	CDD:409353	0/1 (0%)
		Ig strand B	42..49	CDD:409353	2/8 (25%)
		CDR1	49..56	CDD:409353	0/6 (0%)
		FR2	57..62	CDD:409353	1/4 (25%)
		Ig strand C	57..61	CDD:409353	0/3 (0%)
		CDR2	63..84	CDD:409353	5/20 (25%)
		Ig strand C'	71..76	CDD:409353	2/4 (50%)
		Ig strand C'	81..84	CDD:409353	0/2 (0%)
		FR3	91..117	CDD:409353	9/25 (36%)
		Ig strand D	91..96	CDD:409353	1/4 (25%)
		Ig strand E	98..102	CDD:409353	2/3 (67%)
		Ig strand F	112..117	CDD:409353	2/4 (50%)
		CDR3	118..124	CDD:409353	0/5 (0%)
		FR4	125..132	CDD:409353	2/56 (4%)
		Ig strand G	125..131	CDD:409353	1/55 (2%)
		Ig	139..222	CDD:416386	28/102 (27%)
		Ig strand A	139..142	CDD:409353	1/18 (6%)
		Ig strand A'	145..150	CDD:409353	2/4 (50%)
		Ig strand B	154..160	CDD:409353	3/6 (50%)
		Ig strand C	166..171	CDD:409353	1/4 (25%)
		Ig strand C'	173..176	CDD:409353	1/2 (50%)
		Ig strand D	178..182	CDD:409353	1/3 (33%)
		Ig strand E	185..190	CDD:409353	3/4 (75%)
		Ig strand F	200..208	CDD:409353	3/7 (43%)
		Ig strand G	212..221	CDD:409353	3/8 (38%)
		Ig strand A'	233..236	CDD:409353	0/3 (0%)
		Ig_3	236..291	CDD:404760	17/54 (31%)
		Ig strand B	241..249	CDD:409353	2/7 (29%)
		Ig strand C	255..259	CDD:409353	1/3 (33%)
		Ig strand C'	262..265	CDD:409353	1/2 (50%)
		Ig strand E	270..275	CDD:409353	1/4 (25%)
		Ig strand F	283..291	CDD:409353	3/7 (43%)
		Ig strand G	294..304	CDD:409353	3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I12550
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D241176at32523
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.970