DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cacna1eb and para

DIOPT Version :9

Sequence 1:XP_017206695.2 Gene:cacna1eb / 567702 ZFINID:ZDB-GENE-070705-133 Length:2168 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2319 Identity:534/2319 - (23%)
Similarity:933/2319 - (40%) Gaps:663/2319 - (28%)


- Green bases have known domain annotations that are detailed below.


Zfish    46 TVNRSLFIFAENNMIRKYAKRIIEWPPFEYMILATIIANCIVLSLEQHLPGEDKTPMSKRLEKTE 110
            :.::::::....|.||:.|..|:..|.|...|:.||:.|||::.:          |.:..:|.||
  Fly   128 SASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTE 182

Zfish   111 PYFIGIFCFEAGIKLVALGFVFHKGSYLRNGWNVMDFIVVLSGILATAGSHMNIPV-DLRTLRAV 174
            ..|.||:.||:.:|::|.||:....:|||:.||.:||:|:     |.|...|.|.: :|..||..
  Fly   183 VIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVI-----ALAYVTMGIDLGNLAALRTF 242

Zfish   175 RVLRPLKLVSGIPSLQIVLKSIIKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHHTCLADLDI 239
            ||||.||.|:.:|.|:.::.::|:::..|..:.:|..|::.:||::||:.|.|.|...|:....:
  Fly   243 RVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPL 307

Zfish   240 ------LDNETVD-----SSE-------VDF-AC----GVRKCPDKYTC-SGSWIGPNDGITQFD 280
                  |.:|..|     ||.       :.| .|    |..:|.|.|.| .|....||.|.|.||
  Fly   308 DGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFD 372

Zfish   281 NILFAVLTVFQCITMEGWTAVLYNTNDALGPTWNWIYFIPLIIIGSFFVLNLVLGVLSGEFAKER 345
            :..:|.|:.|:.:|.:.|..:......|.|| |:.::||.:|.:|||:::||:|.:::..:.:.:
  Fly   373 SFGWAFLSAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 436

Zfish   346 ERVENRRAFMK--LRRQQQ--------VERELNGY-RAWID--RAEEVMLQEE------------ 385
            ::.|...|..:  :|..::        :|...|.. :|..|  .|||..|..|            
  Fly   437 KKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISY 501

Zfish   386 ---------------NKNSGRS------ALDVLKRATSKKNAR---------------------- 407
                           .|.|.||      ::.|::|..:...|.                      
  Fly   502 ELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNI 566

Zfish   408 RRG------------------PGEEK----------------YSE-------------------- 418
            |||                  ||.::                |::                    
  Fly   567 RRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVY 631

Zfish   419 ----------------------------------ISTVAGGSRPR-------------------- 429
                                              :||:...|:.|                    
  Fly   632 YGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLD 696

Zfish   430 -----------VGM----------------------------------------------RTPRR 437
                       :|:                                              |...|
  Fly   697 TNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDR 761

Zfish   438 GPAAYL-----------RRKERMLRFSIR---------------------RMVKTDSFYWIVLSL 470
            |.:.|.           ..|::.|...::                     .::..|.|..:.::|
  Fly   762 GVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITL 826

Zfish   471 -VALNTISVSIVHHNQPEWLTVIQYYTEFVFLGLFLAEMFLKMYGLGFRLYFHSSFNCFDCGVIV 534
             :.:||:.:::.||:..:.:..:.....:.|...|..|..:|:..:..:.||...:|.||..::.
  Fly   827 CIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVA 891

Zfish   535 GSIFEVVWGFFRPGVSFGISVLRALRLLRIFKITKYWSSLRNLVVSLMS-SMKSIISLLFLLFLF 598
            .|:.|:  |.  .||. |:||||:.||||:||:.|.|.:| ||::|:|. :|.::.:|.|:|.:.
  Fly   892 LSLLEL--GL--EGVQ-GLSVLRSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCII 950

Zfish   599 IVVFALLGMQLFG-------GRFIFEDYTPTNFDTFPASIMTVFQILTGEDWNEVMYNGIRSQGG 656
            |.:||::||||||       .||...|....||..|..|.|.||::|.|| |.|.|::      .
  Fly   951 IFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWD------C 1008

Zfish   657 VHYGMWSSI-YFIVLTLFGNYTLLNVFLAIAVDNLANAQ---ELTKEEEEEEEEFFNQ--RYKSR 715
            ::.|..|.| :|:...:.||..:||:|||:.:.|..::.   .....:..:..|.||:  |:|| 
  Fly  1009 MYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKS- 1072

Zfish   716 EFGLSERRRRPYLYRKRAIHRGRPSPAEAEEEAAGK--QAAEEQPVNAFAGRRERRKKINMSVW- 777
                         :.||.|       |:..:....|  ....:||..      ||..:|:. :| 
  Fly  1073 -------------WVKRNI-------ADCFKLIRNKLTNQISDQPSG------ERTNQISW-IWS 1110

Zfish   778 -----------EQRANQLRKRRQMASREVLFGGPTEDQDTPGSDHHQQHSLSTETSPLHLPESPM 831
                       |...|:|    ::...|:|            :|...:..:..:|      :..:
  Fly  1111 EGKGVCRCISAEHGDNEL----ELGHDEIL------------ADGLIKKGIKEQT------QLEV 1153

Zfish   832 SVGMPLPEPPMSITI----PLPEPPESEPLSGSGLEERPSANNHHANTERRHRVARKFRAAAAAG 892
            ::|     ..|..||    ...:|.:|:.|:.:..::..|.|::                     
  Fly  1154 AIG-----DGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSY--------------------- 1192

Zfish   893 VAEGGRHKRHRHRESRTEARNAENHQQFERQAEDGEGKTEEAQSKHMMNMCDPERQIENQEECQR 957
                |.||....::        |:|   :..||..||:.:...||..:.:   :.:::.:.||: 
  Fly  1193 ----GSHKNRPFKD--------ESH---KGSAETMEGEEKRDASKEDLGL---DEELDEEGECE- 1238

Zfish   958 EFVCDLTGLSQASGHQEEDQAESQEAQLLRHKEDFSTESKYMTEVSDIENNGSYLNQDECMTETS 1022
                        .|..:.|        ::.|..|.....:|..               :|..::.
  Fly  1239 ------------EGPLDGD--------IIIHAHDEDILDEYPA---------------DCCPDSY 1268

Zfish  1023 LKRESSSQPLLEMAPMTVSFKDVEASLSDKADDDDDDDMDDDDDYEDDENGGEKSTASKPERPDS 1087
            .|:    .|:|                   |.|||..                            
  Fly  1269 YKK----FPIL-------------------AGDDDSP---------------------------- 1282

Zfish  1088 MFIFKSKNPIRRICHYVVTLRYFEMTILLVIVASSIALAAED------PVCTSSERNKVLRYFDY 1146
              .::....:|.....::..:|||..::.:|:.||:|||.||      |:.     ..:|.|.|.
  Fly  1283 --FWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPIL-----QDILYYMDR 1340

Zfish  1147 VFTGVFTFEMIIKMIDQGLILHDGSYFRDMWNILDFIVVVGALIAFALTNLLGNNKGRDIKTIKS 1211
            :||.:|..||:||.:..|..:    ||.:.|..|||::|:.:||.| :.:|:|   ...|:..|:
  Fly  1341 IFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVIVMVSLINF-VASLVG---AGGIQAFKT 1397

Zfish  1212 LRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDG 1276
            :|.||.||||:.:.|:..::.|.:.:|.::.::||:|:|..:|..|||::.||||.||:|.|.|.
  Fly  1398 MRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDM 1462

Zfish  1277 SMGTQKECQGYYIDYGRDRKEVKKREWRRHEFHYDNVLWALLTLFTVSTGEGWPQVLQHSVDVTE 1341
            : ||:   ..:.|...|:..|.:...|.....::|:|..|.|.||.|:|.:||.|::..::|..|
  Fly  1463 N-GTK---LSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSRE 1523

Zfish  1342 EDHGPSRGNRMEMSIFYVIYFVVFPFFFVNIFVALIIITFQEQGDK--------MMEECNLEKNE 1398
            .|..|.|...:.|.:::|.:.:...||.:|:|:.:||..|.||..|        |.|:   :|..
  Fly  1524 VDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTED---QKKY 1585

Zfish  1399 RACIDFAISAKPLTRYMPQNRQTLQYRLWHFVVSPSFEYTVLVMIALNTVVLMMKYYSAPTAYDI 1463
            ...:....|.||| :.:|:.|...|..::..|....|:..:::.|.||...:.:..|.|...|:.
  Fly  1586 YNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNA 1649

Zfish  1464 VLKHLNTAFTVLFSLECILKIMAFGFMNYFRDTWNIFDFITVLGSITEIVV-DLQSVNTINMSFL 1527
            ||.:||..|.|:||.||:|||.|..: :||.:.||:||.:.|:.||..:|: |:.....::.:.|
  Fly  1650 VLDYLNAIFVVIFSSECLLKIFALRY-HYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLL 1713

Zfish  1528 KLFRAA---RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLNDE 1589
            ::.|.|   |:::|::....||.||:....|..||..:|||:.::.||:||.||..|.::|  ::
  Fly  1714 RVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVK--EK 1776

Zfish  1590 SHINQHNNFKTFFGALMLLFRSATGESWQEIMLSCLEGKECEPDPSITPPFTSPDHEGGCGT-DF 1653
            |.||...|||||..:::|||:.:|...|..::.:.:..:.|:      ||.....:.|.||: ..
  Fly  1777 SGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACD------PPDNDKGYPGNCGSATV 1835

Zfish  1654 AYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLTRD-SSILGPHHLDEFVRIWGEYDRAACGRIHYN 1717
            ...:.:|::..|..:::|:::|||::|:...|.| ...|.....|.:..||.::|......|.|:
  Fly  1836 GITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYD 1900

Zfish  1718 AMYEMLTHMSPPLGLGKKCPAKIAYKRLVLMNMPVDEDMTVHFTSTLMSLIRTALEIK------I 1776
            .:.|.|..:.|||.:.|  |.|  || ::.|::|:.....::....|.:|.:.....|      .
  Fly  1901 QLSEFLDVLEPPLQIHK--PNK--YK-IISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEET 1960

Zfish  1777 ARGGEDRLQLDMELQKEI-SFIWPHLSQKTLDLLVPINKDTDMTVGKIYASRMIMDFFKQSKAKK 1840
            ...||...:.|.|..:.: |.:|....:                    |.:|:|...:::.||: 
  Fly  1961 GEIGEIAARPDTEGYEPVSSTLWRQREE--------------------YCARLIQHAWRKHKAR- 2004

Zfish  1841 LRLQVEAQRAAAL-PLISHSAGSALTSGGFVALSPISPQELLLQPITQRTDSSED---YDASQVD 1901
                  .:...:. |...|..|....:|     .| :|.|..........|.|.:   ..|:..|
  Fly  2005 ------GEGGGSFEPDTDHGDGGDPDAG-----DP-APDEATDGDAPAGGDGSVNGTAEGAADAD 2057

Zfish  1902 ESGLNGVWGEDRPPEHAFRARHKSYKAAVSHSEQTQYMEKVRGRPKEQRLLLSPKNSNSKSRSRS 1966
            ||.:|.      |.|.|..|...:..||.:.:       ...|.|          .:.|..|..:
  Fly  2058 ESNVNS------PGEDAAAAAAAAAAAAAAGT-------TTAGSP----------GAGSAGRQTA 2099

Zfish  1967 PSEERVHGVTRQGNSSESPVPSTSESSTPSGKRRLSQTSTCSRP 2010
            ...|....||:.|:.      ....|.:||...|.:.. ...||
  Fly  2100 VLVESDGFVTKNGHK------VVIHSRSPSITSRTADVXARPRP 2137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1ebXP_017206695.2 Ion_trans 70..349 CDD:306908 94/303 (31%)
Ion_trans 463..698 CDD:306908 79/247 (32%)
Ion_trans 1108..1387 CDD:306908 97/284 (34%)
Ion_trans 1432..1689 CDD:306908 83/262 (32%)
GPHH 1690..1760 CDD:318993 19/69 (28%)
Ca_chan_IQ 1762..1836 CDD:312334 12/80 (15%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 89/286 (31%)
Na_trans_cytopl 515..648 CDD:288761 13/132 (10%)
Ion_trans 835..1028 CDD:278921 67/205 (33%)
Na_trans_assoc 1054..1296 CDD:284034 60/424 (14%)
Ion_trans 1318..1571 CDD:278921 91/269 (34%)
Na_channel_gate 1561..1613 CDD:240441 14/55 (25%)
Ion_trans 1636..1871 CDD:278921 79/243 (33%)
GPHH 1880..1930 CDD:293510 17/54 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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