DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mbnl1 and mbl

DIOPT Version :9

Sequence 1:	XP_030108561.1	Gene:	Mbnl1 / 56758	MGIID:	1928482	Length:	436	Species:	Mus musculus
Sequence 2:	NP_001261046.1	Gene:	mbl / 36945	FlyBaseID:	FBgn0265487	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	168/472 - (35%)
Similarity:	222/472 - (47%)	Gaps:	126/472 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 RDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQVENGRVIACFDSLKGRCSREN--CKYLHP 71
            :|::||.|||||||||..|||.|||||||||..:.:|:||:|.||:||:||||:|:.  |||.||
  Fly    14 KDSRWLQLEVCREFQRNKCSRQDTECKFAHPPANVEVQNGKVTACYDSIKGRCNRDKPPCKYFHP 78

Mouse    72 PPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVNIMQQSFQKRGGDCISRWEGS 136
            |.|||.||.|||||:|             .|.||:|....:.|                    |.
  Fly    79 PQHLKDQLLINGRNHL-------------ALKNALMQQMGIAP--------------------GQ 110

Mouse   137 PYYTGSDTIYQYCTVEPMFSVAPSLATSASAAFNPYLGPV-----SPSLVPAEILPT--APMLVT 194
            |..:|.               .|::||      ||||..:     ||......::|.  .|..||
  Fly   111 PVISGQ---------------VPAVAT------NPYLTGIPANSYSPYYTTGHLVPALLGPDPVT 154

Mouse   195 GNPGVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMD 259
            ...|..||.....|.||:.|:||||||||:.||.|.|.|::||||||.:| :...:|.::|||||
  Fly   155 SQLGPVVPQTVQVAQQKIPRSDRLEVCREFLRGACKRAESECRFAHPQES-VARHDDGSITVCMD 218

Mouse   260 YIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMT--------QSAVKSLKRP 316
            .:||||:|:.|:|||||.||||::||||   .:|.|..|||.....|        .|....:|..
  Fly   219 AVKGRCARDPCRYFHPPLHLQAQLKAAQ---TRATAVAAAAAVWLYTIYFSILFEPSLCMDVKTV 280

Mouse   317 LEATFDLGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQAL-------------------AN 362
            ....:|......::|  .||||.||:  ...|:..|...|||.:                   ..
  Fly   281 GSFYYDNFQFSGMVP--FKRPAAEKS--GIPVYQPGATAYQQLMQPYVPVSCEYPQQQQQPPPQQ 341

Mouse   363 MQLQQH-------TAFLPPGSILCMTPATS---------------VVPMVHGATPATVSAATTSA 405
            .|.|||       ...|...|::..|..|:               ::..|..:|..|.||.||::
  Fly   342 QQQQQHQQQNVLLQQQLQLSSVITTTSTTATASNNMINNNINNKGIINAVMASTNITSSATTTAS 406

Mouse   406 TSV------PFAATATA 416
            :|:      |...|.||
  Fly   407 SSLLSALGTPPTTTTTA 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mbnl1	XP_030108561.1	ZnF_C3H1	217..241	CDD:214632	16/23 (70%)
mbl	NP_001261046.1	ZnF_C3H1	175..201	CDD:214632	17/25 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837605
Domainoid	1	1.000	149	1.000	Domainoid score	I4407
eggNOG	1	0.900	-	-		E1_KOG2494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I4290
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001679
OrthoInspector	1	1.000	-	-		otm42996
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12675
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2627
SonicParanoid	1	1.000	-	-		X1238
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.880