DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frk and Src42A

DIOPT Version :9

Sequence 1:	XP_021324228.1	Gene:	frk / 567549	ZFINID:	ZDB-GENE-110411-7	Length:	512	Species:	Danio rerio
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	280/540 - (51%)
Similarity:	356/540 - (65%)	Gaps:	65/540 - (12%)

- Green bases have known domain annotations that are detailed below.

Zfish    22 PDTSPSP-------------------DTGKRH-----IEVITNEFAK-----------------P 45
            |.:||||                   ...|:|     ::|:::..::                 |
  Fly  1072 PASSPSPPRPRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHP 1136

Zfish    46 QNRELPPTPV-----LYVALYDYTARTDDDLSFNAGDKLEPITKGEDWWFSKAITGISANKKGYI 105
            ...|||.|.:     |..|.....:.|...||  ..|:....||    .|.|  |.::..|||
  Fly  1137 ATEELPLTAIEKSRSLPAACSASCSHTCAHLS--VIDQSPATTK----CFGK--TSLTTAKKG-- 1191

Zfish   106 PANYVAPV---ESLDAEPWYFPETKRSDAEKMLISQENKKGAFLIRNCESQPGELSLSVRDDVKV 167
            .:..::..   |.|:.:.|||.:.||.:|||.|:..||:.||||||:.||:..:.||||||...|
  Fly  1192 KSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTV 1256

Zfish   168 KHYKIRKLDNGGYYLSTARNFPTLRELVEHYSKHEDGLCVRLAEPCKKSVAPETHGLSYNTVDQW 232
            |||:||:||.||::::....|.||:||||||||..|||||.|.:||.:...|.|.|||:.|.|||
  Fly  1257 KHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQW 1321

Zfish   233 EIERSSVKLLKQLGAGQFGEVFEGLWNDTTPVAVKTLKPGNMDPKDFLREAQIMKKLRHSKLIQL 297
            ||:|:|:|.:::||:||||:|:|||||:|||||:||||.|.|||||||.||||||||||:|||||
  Fly  1322 EIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQL 1386

Zfish   298 YAVCTLEEPIYIITELMSNGSLLEYLQ--NDRGATLRMSDQIDMGAQVASGMAYLELQNYIHRDL 360
            |||||:|||||||||||.:||||||||  ..:|.:|:|...|||.||:|:||||||.||||||||
  Fly  1387 YAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDL 1451

Zfish   361 AARNVLVGDNNVCKVADFGLARVFQMDNEDNVYEAKEGTKFPVKWTAPEAINENKFTIKSDVWSF 425
            |||||||||.|:.|:|||||||:.:.|.    |||:.|.:||:|||||||.|.:||:||||||||
  Fly  1452 AARNVLVGDGNIVKIADFGLARLIKEDE----YEARVGARFPIKWTAPEAANYSKFSIKSDVWSF 1512

Zfish   426 GILLYEIVTFGQTPYPTMTNFQVVQQLPKGYRMSSPPNCHKCLYDIMLDCWKDVPADRPTFETLQ 490
            ||||.|:||:|:.|||.|||.:|:.|:..||||..||||...||:|||:||...|..||||||||
  Fly  1513 GILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQ 1577

Zfish   491 WKLEDFFDMDITSYDDANRF 510
            ||||||:..|.:.|.:|..:
  Fly  1578 WKLEDFYTSDQSDYKEAQAY 1597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frk	XP_021324228.1	SH3_Src_like	56..109	CDD:212779	14/52 (27%)
		SH2_Src_family	117..212	CDD:199827	52/94 (55%)
		PTKc_Frk_like	230..500	CDD:270653	188/271 (69%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	52/90 (58%)
		PTKc_Frk_like	1319..1587	CDD:270653	188/271 (69%)
		Pkinase_Tyr	1328..1580	CDD:285015	176/255 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	366	1.000	Domainoid score	I875
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48065
Inparanoid	1	1.050	583	1.000	Inparanoid score	I976
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto39029
orthoMCL	1	0.900	-	-		OOG6_108172
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3556
SonicParanoid	1	1.000	-	-		X5849
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.000