DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kcnv2a and Shawl

DIOPT Version :9

Sequence 1:XP_695650.4 Gene:kcnv2a / 567267 ZFINID:ZDB-GENE-091117-27 Length:518 Species:Danio rerio
Sequence 2:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster


Alignment Length:530 Identity:135/530 - (25%)
Similarity:212/530 - (40%) Gaps:155/530 - (29%)


- Green bases have known domain annotations that are detailed below.


Zfish    86 INVGGKVYQISYRVAAKYPKTRIGRLATYTDHNRKLDLCDDYTVHNNEFFFDRDPDVFHNIFNFY 150
            :||.|..|:.......|.|.||:.||.         :...:|....||:||||.|.||..|.|:|
  Fly     9 LNVSGIRYETYKATLKKIPATRLSRLT---------EALANYDPVLNEYFFDRHPGVFTQILNYY 64

Zfish   151 RTGVLWIKDELCPRNFLEEINYWGVRIKNTHRCCRISFEERQDELNEQLKVQRELEAEVETEEHE 215
            |||.|....::|...|.||:.:||:.......||..::...:|..| .|.:..:|:.|.|....|
  Fly    65 RTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQN-TLAILDKLDIENEKPTEE 128

Zfish   216 DLFQDMAFGHTRFL--------------IWNMMEKPFSSIIAKIMAVASSFFVLVSLVAMTLNT- 265
            .:.:  .||....|              ||.|.::|.||..|||:|..|.||:.||:::..|.| 
  Fly   129 QIAR--LFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTH 191

Zfish   266 --------------------------------VEEMQY--------------------------- 271
                                            .:..||                           
  Fly   192 PGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSG 256

Zfish   272 -ITTNGQ------------------LSG-----------------------KTYCE------YVE 288
             .|.:||                  ::|                       :||.:      |||
  Fly   257 NFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVE 321

Zfish   289 TFCIAFFTMEYLLRLVSTPDLTRFGRSVLNAVDLIAILPLYLQMVLESFESHDYWKHGSDIETVG 353
            ..|..:|.:|.::||:.:|:|.:|.:|.:|.:|..|.|..|                   .:.:.
  Fly   322 LVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-------------------TDVMQ 367

Zfish   354 RVGKLGQVLRIMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLFLFIAMGILTFSAMVYTV 418
            |:|:...:|....::||.|:.||.|||.|||....|.:...:::..|..|:.:||:.|:::.|..
  Fly   368 RMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYA 432

Zfish   419 E--HDVHKTNFTSIPHAWWWAAVSISTVGYGDMFPETHLGRIFAFACISFGIILNGMPISILFNK 481
            |  .|.....|.|||...|||.|:::||||||:.|:|:.|......|...|::...:|:.::.:.
  Fly   433 EKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSN 497

Zfish   482 FSDYYSKLKA 491
            ||.:||..:|
  Fly   498 FSMFYSHTQA 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kcnv2aXP_695650.4 BTB 84..175 CDD:295341 32/88 (36%)
BTB 86..175 CDD:197585 32/88 (36%)
Ion_trans 285..490 CDD:278921 64/212 (30%)
Ion_trans_2 403..484 CDD:285168 28/82 (34%)
ShawlNP_001097131.2 BTB 7..99 CDD:197585 34/98 (35%)
BTB_2 7..97 CDD:280393 33/96 (34%)
Ion_trans 307..506 CDD:278921 66/217 (30%)
Ion_trans_2 <449..499 CDD:285168 16/49 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D818306at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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