Protein Alignment JPH1 and jph1b

DIOPT Version :10

• Sequence 1: NP_065698.1
• Gene: JPH1 / 56704
• HGNCID: 14201
• Length: 661
• Species: Homo sapiens
• Sequence 2: NP_001037813.1
• Gene: jph1b / 556485
• ZFINID: ZDB-GENE-060616-389
• Length: 673
• Species: Danio rerio
• Alignment Length: 702
• Identity: 473/702 - (67%)
• Similarity: 539/702 - (76%)
• Gaps: 70/702 - (9%)

Human     1 MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWA 65
            |||||||||||||:|||||:|||||||||||||||||||||||:||||||.|||||||||:||||
Zfish     1 MTGGRFDFDDGGTFCGGWEDGKAHGHGICTGPKGQGEYSGSWSNGFEVVGVYTWPSGNTYKGYWA 65

Human    66 QGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQ 130
            ||||||||||:||:|:|||||||||||||||||||.|||||||||||||||||||||||||||||
Zfish    66 QGKRHGLGVESKGRWLYRGEWSHGFKGRYGVRQSLNTPARYEGTWSNGLQDGYGVETYGDGGTYQ 130

Human   131 GQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDAAAAADSPAGTRGGFVL 195
            |||.||||||||||||||||||||||||||||||||||||||||||||  ..:||||||||||||
Zfish   131 GQWMGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHD--HMSDSPAGTRGGFVL 193

Human   196 NFHADAELAGKKKGGLFRRGSLLGSMK-LRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISF 259
            |||:|:|:...||.||||||||.||:| ||||:|:|||||||||.||||.|||||||||||||||
Zfish   194 NFHSDSEVVSGKKKGLFRRGSLFGSLKQLRKSDSRSSISSKRSSARSDATMSRISSSDANSTISF 258

Human   260 GD--VDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFP 322
            ||  |..::.|.||:|||||||:|:||||||||||||||||||||||||||.||||||||||:||
Zfish   259 GDGEVADEYMPAEDNVDATTTESYLGEWKNDKRNGFGVSERSNGMKYEGEWINNKRHGYGCTMFP 323

Human   323 DGSKEEGKYKNNILVRGIRKQLIPIRHTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAK 387
            ||:|||||||||:|||||:|||||:::|||::|||||:|||.||:|:||||||||.|||||||||
Zfish   324 DGTKEEGKYKNNVLVRGIKKQLIPLKNTKTKQKVDRAVEGAIRASAIARTKVEIATSRTAHARAK 388

Human   388 ADAADQAALAARQECDIARAVARELSPDFYQPGPDYVKQRF-QEGVDAKENPEEKVPEKPPTPKE 451
            |:|||||:|:|.||.|:||||||:|||:|:||||||:|||| .|.::.||.||||   |..:|..
Zfish   389 AEAADQASLSASQESDLARAVARDLSPNFHQPGPDYIKQRFSSEPIEIKEVPEEK---KEKSPSG 450

Human   452 SPHFYRKGTTPPRSPEASPKHSHSPA------------SSPKPLKKQNPSSGARLN--------- 495
            |||||||||||.:||..||..:..|:            |:||.:|:..|.:...|.
Zfish   451 SPHFYRKGTTPTQSPSQSPGPTPPPSPPLTKKKPFFNRSAPKAIKENKPPAAENLAAGVSKANTR 515

Human   496 -QDKRSVADEQVTAIVNKPLMSKAPTKEAGAVVPQSKYSGRHHIPNPSNGELHSQYHGYYVKLNA 559
             .||:.|..|.|.  |.||....||...|.               :|.|||||:||||||||...
Zfish   516 ISDKQEVNQEVVP--VAKPSKPLAPVANAS---------------SPGNGELHTQYHGYYVKAEV 563

Human   560 PQHPPVDVEDGD-----GSSQSSSALVHKPSANKWSPSKS----VTKPV-AKESKAEPKAKKSEL 614
             ..||.::||.:     ...::|:||...|     .|.|.    ..||| |||||.|||.||.|.
Zfish   564 -MMPPDELEDEEHHHHHHHHETSTALTRMP-----PPVKQYRAPTPKPVMAKESKPEPKLKKQES 622

Human   615 AIPKNPASNDSCPALE-----KEANSGPNSIMIVLVMLLNIGLAILFVHFLT 661
            ..||:.|..... ::|     .|..||||||:::||||:||||||:||||||
Zfish   623 LKPKSLAETKKA-SMEITTDIVEEESGPNSILVILVMLINIGLAIIFVHFLT 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JPH1	NP_065698.1	COG4642	<3..333	CDD:443680	289/332 (87%)
		MORN 1	14..36		19/21 (90%)
		MORN 2	38..59		18/20 (90%)
		MORN 3	60..82		18/21 (86%)
		MORN 4	106..128		21/21 (100%)
		MORN 5	129..151		20/21 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..247		15/18 (83%)
		MORN 6	281..303		20/21 (95%)
		MORN 7	304..326		19/21 (90%)
		PHA03247	<405..571	CDD:223021	80/188 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..631		83/234 (35%)
jph1b	NP_001037813.1	COG4642	<2..143	CDD:443680	130/140 (93%)
		PLN03185	38..>342	CDD:215619	263/305 (86%)