Protein Alignment JPH1 and jp

DIOPT Version :10

• Sequence 1: NP_065698.1
• Gene: JPH1 / 56704
• HGNCID: 14201
• Length: 661
• Species: Homo sapiens
• Sequence 2: NP_523525.2
• Gene: jp / 34274
• FlyBaseID: FBgn0032129
• Length: 1054
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 253/613 - (41%)
• Similarity: 337/613 - (54%)
• Gaps: 87/613 - (14%)

Human     1 MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWA 65
            :.||||||:|||||||||:||||||||:|||||.||.|:|:|::||||.|.|.||||:.|:|.|.
  Fly    47 INGGRFDFEDGGTYCGGWDEGKAHGHGVCTGPKHQGAYAGAWNYGFEVSGSYIWPSGSHYEGQWQ 111

Human    66 QGKRHGLGVETKGKWMYRGEWS-HGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTY 129
            .|:|||||||..|:.:|||||| .|.|||||||:|..:.|:|||||:.|.|||.|.|||.|||.|
  Fly   112 NGRRHGLGVEQIGRQIYRGEWSKDGHKGRYGVRESTVSTAKYEGTWNEGYQDGSGCETYADGGKY 176

Human   130 QGQWAGGMRHGYGVRQSVPYGMAT-VIRSPLRTSLASLRSEQSNGSVLHDAAAAADSPAGTRGGF 193
            ||||..|.|||||:|.|.|:|:|: ..|..|..||:||||.: ||    :||...:.....||||
  Fly   177 QGQWQEGKRHGYGIRTSAPFGLASHHRRKNLHASLSSLRSGE-NG----NAAKMVEKAEEIRGGF 236

Human   194 VLNFHAD---------AELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRIS 249
            ||...:|         .:..|||        ..|.::|:||..|...: .||.::.|.:..|.:|
  Fly   237 VLTAKSDKLPVRRNSLTDKTGKK--------GFLMNLKMRKQRSTGDL-EKRGTIASGSIRSTMS 292

Human   250 SSDANSTISFG-------------DVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNG 301
            |:   |.||.|             :.:..|...::.:|.|..||||||||.|||.|.||:|||:|
  Fly   293 SA---SWISTGSEQSNLTTKSNHTESNASFTMEDEQLDPTVVETYMGEWKKDKRCGHGVAERSDG 354

Human   302 MKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGIRKQ-LIPIRHTKTREKVDRAIEGAQR 365
            :||||||.||::||||.|.|.||:.||||||||||:...:|: |...|..|.|:::..|:..|||
  Fly   355 LKYEGEWYNNRKHGYGVTTFRDGTVEEGKYKNNILITSQKKKHLFLARSRKLRDRIAAALSSAQR 419

Human   366 AAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYV------ 424
            |..||..:.::|.||.|.|.|||..||.||..||.:|:.|..:|||.:|||   .|..:
  Fly   420 ALKMAMQRSDMAISRMATAAAKAQNADAAAEQARMDCENAVRMAREFAPDF---KPSVLERFEKL 481

Human   425 ----KQRFQEGVDAKENPEEKVPEKPPTPKESPHFYRKGTTPPRSPEASPKHSHSPASSPKPLK- 484
                ::||:.|..|..:...|:.....|.::.   .::|...|.|...|..::.......:.|.
  Fly   482 RFRERERFRPGPAAASDASVKMGVGLQTQQQQ---QQQGQFSPTSSSGSDAYATQAQRQQQYLNM 543

Human   485 KQNPSSGARLNQDKRSVADEQVTAIVNKPLMSKAPT-----KEAGAVVPQSKYSGRHHIPNPSNG 544
            :|......|::|.|..               |:.|.     .:...|.||:..||......||:.
  Fly   544 QQQQQQQRRMSQQKHE---------------SECPVPPSMYSQQLPVSPQTDLSGMVSQAQPSHA 593

Human   545 EL--------HSQYHGYYVKLNAPQHPP 564
            ::        |.|.|....:||..|..|
  Fly   594 QVISAINQMYHQQQHQQQQQLNQQQSNP 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JPH1	NP_065698.1	COG4642	<3..333	CDD:443680	182/353 (52%)
		MORN 1	14..36		18/21 (86%)
		MORN 2	38..59		13/20 (65%)
		MORN 3	60..82		12/21 (57%)
		MORN 4	106..128		15/21 (71%)
		MORN 5	129..151		14/21 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..247		4/18 (22%)
		MORN 6	281..303		16/21 (76%)
		MORN 7	304..326		15/21 (71%)
		PHA03247	<405..571	CDD:223021	39/184 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..631		28/146 (19%)
jp	NP_523525.2	COG4642	<49..194	CDD:443680	99/144 (69%)
		PLN03185	84..>384	CDD:215619	150/316 (47%)