Protein Alignment JPH1 and jph-1

DIOPT Version :10

• Sequence 1: NP_065698.1
• Gene: JPH1 / 56704
• HGNCID: 14201
• Length: 661
• Species: Homo sapiens
• Sequence 2: NP_492193.2
• Gene: jph-1 / 266843
• WormBaseID: WBGene00002179
• Length: 747
• Species: Caenorhabditis elegans
• Alignment Length: 780
• Identity: 285/780 - (36%)
• Similarity: 397/780 - (50%)
• Gaps: 161/780 - (20%)

Human     1 MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWA 65
            |.||||||||||||.||||||||||||:||||:.:|||:|:|.:||||.|.|||||||||||.|.
 Worm     1 MNGGRFDFDDGGTYVGGWEEGKAHGHGVCTGPQAKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQ 65

Human    66 QGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQ 130
            .|||||||:|.:|:|:|:|||:.|:|||||||||..:.|||:||||.|..||||.|.|.|.|:||
 Worm    66 NGKRHGLGIEQRGRWLYKGEWTQGYKGRYGVRQSANSQARYQGTWSAGFHDGYGTEIYVDSGSYQ 130

Human   131 GQWAGGMRHGYGVRQSVPYGMATVIRSPLRT--SLASLRS---EQSNGSVLHDAAAAADSPAGTR 190
            |||..|||||||:|:|..|..|...||..:|  ||.||||   |:.|.:..|........    |
 Worm   131 GQWLRGMRHGYGIRKSTTYEKAAKFRSKSQTHASLTSLRSGRVEEENAAEEHRHKEGLSG----R 191

Human   191 GGFVLNFHADAELAGKKKGGLFRRG-----SLLGSMKLRKSESKSSI----SSKRSSVRSDAAMS 246
            |||||  .|::....:::..|..|.     :||..::::|..|...|    :|...|:||..:..
 Worm   192 GGFVL--RANSSAPQRRRRSLSERSLAVKRTLLSGLRIKKQHSTGDIHQRVASMTGSLRSSGSTM 254

Human   247 RISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANN 311
            ..:|.|:........      |.|:.|:.::.||||||||||.|:||||.|||:|:||:||||||
 Worm   255 SCTSEDSLHHHGLQQ------PEEEAVEESSIETYMGEWKNDMRSGFGVCERSDGLKYQGEWANN 313

Human   312 KRHGYGCTVFPDGSKEEGKYKNNILVRGI-RKQLIPIRHTKTREKVDRAIEGAQRAAAMARTKVE 375
            .:.|||.|.|.||:||||:||||||:... ||.:|.:|.:|.|||:::|:..|.|||::|:.|.:
 Worm   314 AKCGYGVTTFKDGTKEEGRYKNNILIASSRRKGVIFMRASKFREKLEQALGAASRAASIAQQKAD 378

Human   376 IANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPG-------------------- 420
            ||.|||:.||.:::.|...|..|..:.::||..|::..|.|.|||
 Worm   379 IAASRTSTARERSEQASFIARQANDDSEVARIHAKQFDPSFKQPGTRRLLKDNNGGESFGTDLSD 443

Human   421 ---------PDYVKQR-FQE--GVDAKEN--PEEKVPEKPPTPKES-------PHFYRKGTTPPR 464
                     ..:.||. |::  .||..|:  |..|.......|..:       |.:   |.:.|.
 Worm   444 AISYSRHLSQTHSKQHSFEQTLSVDMAEDMTPPSKAYHNHVMPNSNTNHVNFMPQY---GYSDPN 505

Human   465 SPEASPKHS------HSPASSP------------KPL--------KKQNPSS----GARLNQDKR 499
            |...:|.:|      |.|...|            |||        .:..||:    ...:...:.
 Worm   506 SQLQTPINSQDLLQPHIPNIDPSIPSVSIVQDDEKPLILQPQTNISQPGPSNLSTQAPNVMSSRF 570

Human   500 SVADEQVTAIV-------------NKP-LMSKAPTKEAGAVVPQSKYSGRHHIPN--PSNGEL-H 547
            |::|:.....|             |:| ||.:|...|:.|.   |..:.|..:.:  ..||:: |
 Worm   571 SLSDDHYDQYVMAGGAQQQQKLRRNRPSLMRQADVNESCAA---SGLNRRSTLASARDRNGDVNH 632

Human   548 SQYHG--YYVKLNAPQHPPVDVEDGD--GSSQSSSAL------VHKPSANKWSPSKSVTKPVAKE 602
            ....|  :..||.|.      ..|||  ||..:.:.|      :.:..|.:          :|.:
 Worm   633 PGAIGATHAAKLTAA------TSDGDNMGSLPNLAELETQGVRLRREEAAR----------LAGQ 681

Human   603 SKAEPKAKKSELAIPK-NPASNDSCPALEKEANSGPNSIMI-----VLVMLLNIGLAILFVHFLT 661
            .:.|...:..|.|:.: ||..:...||.        .:.::     :|:.:.||.|.:||.|.||
 Worm   682 RRQEVLRENEEAALLRANPLRHFLQPAF--------RAWLVRWRIPILLAIANISLLMLFYHLLT 738

Human   662  661
             Worm   739  738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JPH1	NP_065698.1	COG4642	<3..333	CDD:443680	180/343 (52%)
		MORN 1	14..36		17/21 (81%)
		MORN 2	38..59		14/20 (70%)
		MORN 3	60..82		14/21 (67%)
		MORN 4	106..128		13/21 (62%)
		MORN 5	129..151		15/21 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..247		6/22 (27%)
		MORN 6	281..303		17/21 (81%)
		MORN 7	304..326		14/21 (67%)
		PHA03247	<405..571	CDD:223021	51/255 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..631		53/264 (20%)
jph-1	NP_492193.2	COG4642	<2..145	CDD:443680	102/142 (72%)
		MORN	283..303	CDD:308220	16/19 (84%)
		MORN	306..328	CDD:308220	14/21 (67%)