DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbnl3 and mbl

DIOPT Version :9

Sequence 1:	XP_009289402.1	Gene:	mbnl3 / 567027	ZFINID:	ZDB-GENE-081002-3	Length:	393	Species:	Danio rerio
Sequence 2:	NP_001261046.1	Gene:	mbl / 36945	FlyBaseID:	FBgn0265487	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	446	Identity:	171/446 - (38%)
Similarity:	224/446 - (50%)	Gaps:	103/446 - (23%)

- Green bases have known domain annotations that are detailed below.

Zfish     8 GRDTKWLTLEVCREFQRGTCSRSDSECKFAHPSRTCHVENGRVIACFDSLKGRCTRDN--CKYLH 70
            |:|::||.|||||||||..|||.|:|||||||.....|:||:|.||:||:||||.||.  |||.|
  Fly    13 GKDSRWLQLEVCREFQRNKCSRQDTECKFAHPPANVEVQNGKVTACYDSIKGRCNRDKPPCKYFH 77

Zfish    71 PPPHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMLPGAQLQPITSFPV-----TPSLANSPSMAF 130
            ||.|||.||.|||||:|..:..    |.|||. :.||   ||:.|..|     .|.|...|:.::
  Fly    78 PPQHLKDQLLINGRNHLALKNA----LMQQMG-IAPG---QPVISGQVPAVATNPYLTGIPANSY 134

Zfish   131 SPYLS--HVSPGISLMPELLPSAPV---LVPGSPTGITMGNGNSTQKHVRTDKLEVCREFQRGNC 190
            |||.:  |      |:|.||...||   |.|..|..:.:    :.||..|:|:|||||||.||.|
  Fly   135 SPYYTTGH------LVPALLGPDPVTSQLGPVVPQTVQV----AQQKIPRSDRLEVCREFLRGAC 189

Zfish   191 TRGENDCRYAHPMEAAMVDGSENSVIVCMDYIKGRCTRDKCKYFHPPAHLQARIKAAQHQASQNA 255
            .|.|::||:|||.| ::....:.|:.||||.:||||.||.|:|||||.||||::||||.:|:..|
  Fly   190 KRAESECRFAHPQE-SVARHDDGSITVCMDAVKGRCARDPCRYFHPPLHLQAQLKAAQTRATAVA 253

Zfish   256 AAMAL------------PPGAMQ----------------QLP-KRPTLEKSNGAAAVFNPSMFHY 291
            ||.|:            |...|.                .:| |||..|||  ...|:.|....|
  Fly   254 AAAAVWLYTIYFSILFEPSLCMDVKTVGSFYYDNFQFSGMVPFKRPAAEKS--GIPVYQPGATAY 316

Zfish   292 QQALASMQLQQPAFIPTGSVFCMAPSGGIGLFKPPGPMTEGRWERRDWTGCRAPQSRYLSGPGHT 356
            |      ||.|| ::|   |.|..|...    :.|.|..: :.::.........|...||....|
  Fly   317 Q------QLMQP-YVP---VSCEYPQQQ----QQPPPQQQ-QQQQHQQQNVLLQQQLQLSSVITT 366

Zfish   357 VPMMHGATTSTVS--------------SATTPVTNVPFAESATSNQ-------TPP 391
            .     :||:|.|              :|....||:..:.:.|::.       |||
  Fly   367 T-----STTATASNNMINNNINNKGIINAVMASTNITSSATTTASSSLLSALGTPP 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbnl3	XP_009289402.1	ZnF_C3H1	17..39	CDD:214632	17/21 (81%)
mbnl3	XP_009289402.1	ZnF_C3H1	178..203	CDD:214632	16/24 (67%)
mbl	NP_001261046.1	ZnF_C3H1	175..201	CDD:214632	16/25 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2494
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H23101
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001679
OrthoInspector	1	1.000	-	-		otm25318
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1238
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.800