DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PSG2 and wrk-1

DIOPT Version :9

Sequence 1:	NP_112536.2	Gene:	PSG2 / 5670	HGNCID:	9519	Length:	335	Species:	Homo sapiens
Sequence 2:	NP_001024651.1	Gene:	wrk-1 / 181093	WormBaseID:	WBGene00006942	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	355	Identity:	74/355 - (20%)
Similarity:	125/355 - (35%)	Gaps:	84/355 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    17 GLLVTASLLNFWNLPTTAQVTIEAQPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQIRDLYHYITS 81
            |||:.:         |:||:..:.......||:. |.|...:.......||.|.         |.
Worm    10 GLLIAS---------TSAQIRTKGGTLIAKEGES-LTLRCEVEDPSVAIIWRKN---------TE 55

Human    82 YV-VDGQIIIYGPAYSGRETAY--SNASLLIQNVTREDAGSYTLHIIKRGDGTRGVTGYFTFTLY 143
            .| ||.:|:   ..|.|.|.:.  |.:.|.|:.|...::.:|:..:.:.....       ||.:.
Worm    56 VVAVDDEIL---DTYGGYEISMEGSTSVLTIKRVEPINSANYSCALAEPEVSV-------TFVIK 110

Human   144 LETPKPS-ISSSNL----------NPREAMETVILTCDPE--TPDTSYQWWMNGQSLPMTHRFQL 195
            ::..||: :|...|          :.|...:.:::||..:  .|.....|......||  ...:.
Worm   111 VQVFKPTQVSVKPLVVISPDTGVYHARVGEKNLVITCHVKEGNPKPGVVWTKQAAKLP--EDIKR 173

Human   196 SETNRTLFLFGVTKYTAGPYECEIRNSGSASRSDPVTLNL-----LHG--PDLPRI--HPSYTNY 251
            ......:.:..|.|:.||.|.|...|   .:.||..|:::     |.|  .:.|.:  ..::...
Worm   174 EHGGARIVITEVKKHHAGKYNCLAEN---IAGSDRATIDIHVAEPLQGEREEKPWVKNEDTFIPV 235

Human   252 RSGDNLYLSCFANSNPPAQYSWTING--------KFQQSGQ-----------NLFIPQITTKHSG 297
            |...|....|..:..|..|..|..||        ||:::.:           .|.:..|:.:..|
Worm   236 RKNQNASFWCTYDGTPVPQVEWLFNGYKINFNDEKFKKTSETAQRLNGYSKSTLTVGDISEEAFG 300

Human   298 LYVCSVRNSATGEESSTSLTVKVSASTRIG 327
            .|.|.:.|..      .|:|..|..|.|.|
Worm   301 DYACRISNKL------GSVTAVVHVSGRPG 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSG2	NP_112536.2	Ig_CEACAM_D1	36..138	CDD:143251	20/104 (19%)
		IG_like	45..>121	CDD:214653	19/78 (24%)
		Ig	148..236	CDD:299845	21/105 (20%)
		Ig_2	242..320	CDD:290606	19/98 (19%)
		IG_like	246..318	CDD:214653	17/90 (19%)
wrk-1	NP_001024651.1	IG_like	25..113	CDD:214653	22/107 (21%)
		IGc2	31..96	CDD:197706	20/77 (26%)
		IG_like	132..212	CDD:214653	17/84 (20%)
		IGc2	142..202	CDD:197706	13/64 (20%)
		IG_like	235..320	CDD:214653	19/90 (21%)
		Ig	245..318	CDD:143165	16/78 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000