DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lrrc4.2 and Fili

DIOPT Version :9

Sequence 1:	NP_001093494.1	Gene:	lrrc4.2 / 566572	ZFINID:	ZDB-GENE-030131-7997	Length:	644	Species:	Danio rerio
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	694	Identity:	163/694 - (23%)
Similarity:	272/694 - (39%)	Gaps:	114/694 - (16%)

- Green bases have known domain annotations that are detailed below.

Zfish     8 TVHRAWNAALLCA---VYLMVRSWSVSAAPSGQLTCPSVCFC--SNVSNKVVCTRRSLVRVPPGI 67
            |..|.|    ||.   |.|::....|...|.....|||.|.|  ...:::.:|...:|..||..:
  Fly    11 TRSRPW----LCGAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQL 71

Zfish    68 PATTRHLNLMENSIETIEAGTFQHLRHLEVLQLGRNSIRQIEVGAFSGLNSLNTLELFDNRLTVI 132
            ...|:::||..|.|.|:|.....::: ||:|.|.:|.|..:....|...:.|.||.|..|.::.:
  Fly    72 NPETKYINLTVNRIRTLEFSLPFYMK-LEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSL 135

Zfish   133 PSGAFEYLSKLRELWLRSNPIESIPSYAFNRVPSLMRLDLGELRKLEYISEGAFEGLHNLKYLNL 197
            ...||:.|:.|..|.|..|.||::...|.:.:.||:.|||.. ..:..:.:..|:|::.|:.|..
  Fly   136 HKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTN-NNIVSLEDNCFKGMNTLEVLVF 199

Zfish   198 GMCNLREMPV--LTPLVGLEELEMSENYFPELKPGSFRGLKSLKKLWIMNSRITTIERNAFDDVT 260
            ....|.::|.  |..|..|:.|:||.|....::..||.|||.|..|.:..:.::.::.:||:.:.
  Fly   200 RNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLI 264

Zfish   261 ALVELNLAHNNLSSLPHDLFAPLSYLVELHLHHNPWRCDCDVVWL-AWWLREYIPTNSTCCGRCH 324
            :|..|:|:.|||:.:|....:.||.|..|:|..|.:.....|.:| .:.|||...:......|..
  Fly   265 SLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRID 329

Zfish   325 TPAYLRGRYLVEVDQSTFQCSAPFILDAPRDLNISAERVAELKCRTAPMSSVRWLLPNGTVLTHG 389
            :.|::...:|    |:....:.|.:.|.|..|......:.|:           ::..|.....:.
  Fly   330 SRAFVDNTHL----QTLHLNNNPQLSDIPMRLFQGNPNILEV-----------YMQSNSLQTLYS 379

Zfish   390 SNHP----RISVLNDGTL---------------NFSNVLP----------------ADTGVYTCM 419
            :..|    :...|.|..|               ||..|.|                ||.......
  Fly   380 AQFPVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADE 444

Zfish   420 VTNMAGNSNASAYLNVTAAELNTSNLSYFTTVTVEEVEPTSQEVIKPKTVTASPSVFQPVFISTP 484
            .|.:|...:..|.|....||.:..|..:.|       ||::.|:     .|:|.:       ...
  Fly   445 ATAVASTDDGVAALAAYIAEQHIVNALHTT-------EPSAYEL-----ATSSSN-------RNS 490

Zfish   485 TVLLQTPRQVSVPTVRGTTRPPASL-----DEVMKTTKII-IGCFVAVTLLAAVMLIA-FYKLRK 542
            .:|....:|:.....|...|....|     .|:.....|: :.|.|...||.|::.|: .|.||.
  Fly   491 GILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRF 555

Zfish   543 RHQQRSTVAASGTMEAIQMDENV-----------------STTHAGTSIPGECGMMLPSLRDHNS 590
            ..::|..:...|.|...:...||                 |.|..|.:.....||.| :...|..
  Fly   556 VKRRRKLLHERGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTL-NYPHHAQ 619

Zfish   591 TYKPSSYRPAHSAPWAENNIGNSLHRSRPMTISTIP----EPYL 630
            |.:  ::...|.|...:::.||..|..:..|:..:.    |.||
  Fly   620 TLQ--AHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLELERYL 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lrrc4.2	NP_001093494.1	leucine-rich repeat	71..94	CDD:275380	7/22 (32%)
		LRR_8	72..129	CDD:290566	18/56 (32%)
		LRR_RI	74..>276	CDD:238064	61/203 (30%)
		leucine-rich repeat	95..118	CDD:275380	7/22 (32%)
		leucine-rich repeat	119..142	CDD:275380	8/22 (36%)
		LRR_8	141..202	CDD:290566	16/60 (27%)
		leucine-rich repeat	143..166	CDD:275380	7/22 (32%)
		leucine-rich repeat	167..191	CDD:275380	6/23 (26%)
		leucine-rich repeat	192..213	CDD:275380	6/22 (27%)
		LRR_8	213..272	CDD:290566	18/58 (31%)
		leucine-rich repeat	214..237	CDD:275380	9/22 (41%)
		leucine-rich repeat	238..261	CDD:275380	4/22 (18%)
		leucine-rich repeat	262..283	CDD:275380	7/20 (35%)
		LRRCT	294..345	CDD:214507	10/51 (20%)
		IG_like	353..435	CDD:214653	18/116 (16%)
		Ig	365..435	CDD:299845	16/104 (15%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	7/21 (33%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	20/60 (33%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	52/197 (26%)
		leucine-rich repeat	170..193	CDD:275380	6/23 (26%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		leucine-rich repeat	218..265	CDD:275380	14/46 (30%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	5/23 (22%)
		LRR_8	337..397	CDD:404697	11/74 (15%)
		leucine-rich repeat	339..360	CDD:275380	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910