DRSC/TRiP Functional Genomics Resources

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Protein Alignment TWNK and YLH47

DIOPT Version :10

Sequence 1:NP_068602.2 Gene:TWNK / 56652 HGNCID:1160 Length:684 Species:Homo sapiens
Sequence 2:NP_015450.1 Gene:YLH47 / 856243 SGDID:S000006329 Length:454 Species:Saccharomyces cerevisiae


Alignment Length:476 Identity:83/476 - (17%)
Similarity:166/476 - (34%) Gaps:147/476 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   158 WNRAIPLWELPDQEEVQLAD-TMFGLTKVTDDTLKR---FSVRYLRPARSLVFPWFSPGGSGLRG 218
            ||.::|   ...::|::..| .....:||:....|.   |.|:..:..|..   |   .||.|.|
Yeast    45 WNSSVP---ESSKKELKTTDGNQESASKVSPVKEKEKVPFKVKMQKALRHY---W---DGSKLLG 100

Human   219 LKLLEAKCQGDGVSYEETTIPRPSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLP---T 280
            |:          :......:.:.:|     |.||..|.:.::..|::::..|       :|   .
Yeast   101 LE----------IKISSKLLMKSAA-----GYPLTRRENLQLKRTTQDIVRL-------VPFAAF 143

Human   281 LTLPRGTTCLP------PALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKL----NPKRCF--LV 333
            |.:|.....||      |.|||                .::|::|....||    |.::..  ::
Yeast   144 LIIPFAELLLPFALKLFPNLLP----------------STYESSKKRENKLENLRNTRKLMSEII 192

Human   334 RPGDQQPRP---LEALNGGFN--LSRILRTALPAWHKSIVSFRQL-REEVLGELSNVEQAAGLRW 392
            :......:|   .|.....||  .:.:..|.:|...:.::...:| .::.:  |.||.:...:..
Yeast   193 KNNKSHFKPNNISEEQKALFNRFYTHVRATGVPESRQQLIEVARLFTDDTV--LDNVTRPYLIAL 255

Human   393 SRFPDLN----------RI---LKGHRKGELTVFTGPTGSGKTTFISEYALDLCSQGVNT--LWG 442
            :::.:|.          ||   :...:|.:|:::   ....:...:||......|:|:.:  :..
Yeast   256 AKYMNLQPFGTDVMLRYRIRYKMLELKKDDLSIY---YEDAEQLSLSELKTACASRGIRSVDVEP 317

Human   443 SFEISNVRL-------------ARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLYFMTFHGQQSI 494
            |...||:||             ..:|.|.:..|.::.:...||...|....:|            
Yeast   318 SVLYSNLRLWLNMRLKDKIPSTLLIMATAYNYGNVQSKESLYDALCDVLIGIP------------ 370

Human   495 RTVIDTMQHAVYVYDICHVIIDN--------LQFMMGHEQLSTDRIAAQDYIIGVFRKFATDNNC 551
                |.:.|.|.|    :|:.::        .|.....|.:..:....::.|:.|..:.:.|   
Yeast   371 ----DELYHEVKV----NVVKEDEASAKQKLKQLREQEEIMKEEEQQEENAIVSVKDELSLD--- 424

Human   552 HVTLVIHPRKEDDDKELQTAS 572
                       |.||.:..|:
Yeast   425 -----------DQDKNIDAAA 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TWNKNP_068602.2 Contributes to single strand DNA binding activity. /evidence=ECO:0000269|PubMed:18039713 1..121
N-terminal region (NTR). /evidence=ECO:0000269|PubMed:35914129 54..214 12/59 (20%)
Required for hexamers formation and DNA helicase activity. /evidence=ECO:0000269|PubMed:18039713 121..372 44/237 (19%)
Primase-like domain. /evidence=ECO:0000269|PubMed:35914129 215..335 24/134 (18%)
TOPRIM_primases 259..335 CDD:173779 16/90 (18%)
Twinkle_C 366..629 CDD:410867 39/244 (16%)
Maybe required for stable oligomeric structure. /evidence=ECO:0000269|PubMed:17324440 405..590 32/191 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..684
Might negatively regulate ATPase activity. /evidence=ECO:0000269|PubMed:17324440 640..684
YLH47NP_015450.1 LETM1_RBD 119..348 CDD:462258 44/256 (17%)
Blue background indicates that the domain is not in the aligned region.

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