| Sequence 1: | NP_068602.2 | Gene: | TWNK / 56652 | HGNCID: | 1160 | Length: | 684 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_014615.1 | Gene: | MDM38 / 854130 | SGDID: | S000005387 | Length: | 573 | Species: | Saccharomyces cerevisiae |
| Alignment Length: | 243 | Identity: | 48/243 - (19%) |
|---|---|---|---|
| Similarity: | 84/243 - (34%) | Gaps: | 90/243 - (37%) |
- Green bases have known domain annotations that are detailed below.
|
Human 514 IIDNLQFMMGHEQLSTDRIAAQDYIIGVFRKFATDNNCHVTLVIHPRKED---DDK--------- 566
Human 567 ----ELQTASIFGSAKA--------------------SQEADNVLILQDRKLVTG--PGKRYLQV 605
Human 606 ---------SKNRFDG---------------------DVGVFPLEFNKNSLTFSIPPKNKARLKK 640
Human 641 IKDDTGPVAKKPSSGKKGATTQNSEIC-SGQAPTP------DQPDTSK 681 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| TWNK | NP_068602.2 | Contributes to single strand DNA binding activity. /evidence=ECO:0000269|PubMed:18039713 | 1..121 | ||
| N-terminal region (NTR). /evidence=ECO:0000269|PubMed:35914129 | 54..214 | ||||
| Required for hexamers formation and DNA helicase activity. /evidence=ECO:0000269|PubMed:18039713 | 121..372 | ||||
| Primase-like domain. /evidence=ECO:0000269|PubMed:35914129 | 215..335 | ||||
| TOPRIM_primases | 259..335 | CDD:173779 | |||
| Twinkle_C | 366..629 | CDD:410867 | 31/182 (17%) | ||
| Maybe required for stable oligomeric structure. /evidence=ECO:0000269|PubMed:17324440 | 405..590 | 23/111 (21%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 637..684 | 15/52 (29%) | |||
| Might negatively regulate ATPase activity. /evidence=ECO:0000269|PubMed:17324440 | 640..684 | 14/49 (29%) | |||
| MDM38 | NP_014615.1 | LETM1_RBD | 121..358 | CDD:462258 | 23/116 (20%) |
| Blue background indicates that the domain is not in the aligned region. | |||||