DRSC/TRiP Functional Genomics Resources

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Protein Alignment TWNK and twnk-1

DIOPT Version :10

Sequence 1:NP_068602.2 Gene:TWNK / 56652 HGNCID:1160 Length:684 Species:Homo sapiens
Sequence 2:NP_001368724.1 Gene:twnk-1 / 180845 WormBaseID:WBGene00018514 Length:604 Species:Caenorhabditis elegans


Alignment Length:557 Identity:180/557 - (32%)
Similarity:282/557 - (50%) Gaps:92/557 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   145 APEFEDSE--------EVRRIWNRAIPLWELPDQEEV---QLADTMFGLTKVTDDTLKRFSVR-- 196
            :|..:.||        :::|.|:.::.:.:|...:..   || ..|.|:..::.:||.||:||  
 Worm    60 SPRLDASEAMSAPPDPDIKRYWDSSLDITDLSGHDFTIFKQL-QGMLGIENISFETLARFNVRVQ 123

Human   197 ---YLRPARSLVFPWFSPGGSGLR---GLKLLEAKCQGDGVSYEETTIPRPSA----YHNLFGLP 251
               |.:||  ::||.:....|.||   ||||:  :..||.:..|...:|..::    ::.:|||.
 Worm   124 TDTYGQPA--ILFPRYRGMTSRLRIPMGLKLI--RKVGDRMEKENYPLPDETSVRQKFNGVFGLH 184

Human   252 LISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQFRRIVFWLGDDLRSWE 316
            :.:..|..||:|:.|.|:||:.::|......||.| ..|.|.:|||||:|.:|..|.  .::...
 Worm   185 MATLSDRSVVITTNERDALAIYEATKALVFALPHG-EILDPLVLPYLEEFDKIYLWF--PVQHVS 246

Human   317 AAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTALPAWHKSIVSFRQ--------- 372
            .||.:...||..:|.||:   .:.||:|.:..|.:  |::|.:|   ..|:|..|:         
 Worm   247 YAKDWGSALNTLKCLLVK---NEERPIELVRNGDH--RLIRNSL---SNSVVRMRERGFRSMTDL 303

Human   373 -LREEVLGELSN-VEQAAGL-RWSRFPDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALDLCS 434
             :||.:..:|.| ..:..|. :|.||..||:.|.|.|.||:||.||.||:|||||:.||:|||.:
 Worm   304 DMREGIRSDLLNSTNRVVGFGQWKRFAVLNKYLGGLRPGEMTVLTGGTGNGKTTFLCEYSLDLFT 368

Human   435 QGVNTLWGSFEISNVRLARVMLTQFA--------------EGRLEDQLDKYDH------WADRFE 479
            |||.||:.|||:...::...||.|:|              :..::..|.:.::      |.||||
 Worm   369 QGVRTLFCSFEMPEKKILHWMLVQYAGPSHLRSLARTNSYKNGIKLPLHRVEYSNSINSWLDRFE 433

Human   480 DLPLYFMTFHGQQSIRTVIDTMQHAVYVY----DICHVIIDNLQF-----MMGHEQLS-TDRIAA 534
            ...........::.:...|:.:..|:.::    .|.||:||||||     ||..|:.| .||...
 Worm   434 RSSSALTMLDSEEFMEKSINEIVRAIRIHVENSGIQHVVIDNLQFLINQGMMADEKSSGLDRFHL 498

Human   535 QDYIIGVFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQ------DRK 593
            ||..:|..|:.||.|..|:|:|:||||.|.|.|:......|||:.:||||||:.:|      ||.
 Worm   499 QDRFVGYMRQLATQNQIHITMVVHPRKTDGDTEIDVQHFGGSARVTQEADNVIAIQRKRDDRDRS 563

Human   594 LVTGPGKRYLQVSKNRFDG-DVGVFPLEFNKNSLTFS 629
            ..    :::|.:.|||:.| .|....||...|..|:|
 Worm   564 KF----RKFLYILKNRYYGRRVESDQLEMVFNPSTYS 596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TWNKNP_068602.2 Contributes to single strand DNA binding activity. /evidence=ECO:0000269|PubMed:18039713 1..121
N-terminal region (NTR). /evidence=ECO:0000269|PubMed:35914129 54..214 21/84 (25%)
Required for hexamers formation and DNA helicase activity. /evidence=ECO:0000269|PubMed:18039713 121..372 73/249 (29%)
Primase-like domain. /evidence=ECO:0000269|PubMed:35914129 215..335 42/126 (33%)
TOPRIM_primases 259..335 CDD:173779 28/75 (37%)
Twinkle_C 366..629 CDD:410867 108/311 (35%)
Maybe required for stable oligomeric structure. /evidence=ECO:0000269|PubMed:17324440 405..590 80/214 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..684
Might negatively regulate ATPase activity. /evidence=ECO:0000269|PubMed:17324440 640..684
twnk-1NP_001368724.1 Twinkle_C 299..598 CDD:410867 106/302 (35%)
Blue background indicates that the domain is not in the aligned region.

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