Protein Alignment PSEN2 and Psen2

DIOPT Version :10

• Sequence 1: NP_000438.2
• Gene: PSEN2 / 5664
• HGNCID: 9509
• Length: 448
• Species: Homo sapiens
• Sequence 2: NP_112349.2
• Gene: Psen2 / 81751
• RGDID: 621060
• Length: 448
• Species: Rattus norvegicus
• Alignment Length: 448
• Identity: 427/448 - (95%)
• Similarity: 433/448 - (96%)
• Gaps: 0/448 - (0%)

Human     1 MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQENEEDGEEDPDRYVC 65
            |||||||||||||||||||||||||||.||||:.|.|||||||||||||||||:|.|||||.|.|
  Rat     1 MLTFMASDSEEEVCDERTSLMSAESPTSRSCQDSRPGPEDGENTAQWRSQENEDDCEEDPDHYAC 65

Human    66 SGVPGRPPGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPS 130
            |||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 SGVPGRPSGLEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFTEDTPS 130

Human   131 VGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVLKTY 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
  Rat   131 VGQRLLNSVLNTLIMISVIVVMTIFLVVLYKYRCYKFIHGWLIMSSLMLLFLFTYIYLGEVFKTY 195

Human   196 NVAMDYPTLLLTVWNFGAVGMVCIHWKGPLVLQQAYLIMISALMALVFIKYLPEWSAWVILGAIS 260
            |||||||||.|.||||||||||||||||||||||||||:||||||||||||||||||||||||||
  Rat   196 NVAMDYPTLFLAVWNFGAVGMVCIHWKGPLVLQQAYLIVISALMALVFIKYLPEWSAWVILGAIS 260

Human   261 VYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEE 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 VYDLVAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQLPYDPEMEE 325

Human   326 DSYDSFGEPSYPEVFEPPLTGYPGEELEEEEERGVKLGLGDFIFYSVLVGKAAATGSGDWNTTLA 390
            |||||||||||||.||.|..||||||.|||||||||||||||||||||||||||||:|||:||||
  Rat   326 DSYDSFGEPSYPEAFEAPQPGYPGEEPEEEEERGVKLGLGDFIFYSVLVGKAAATGNGDWSTTLA 390

Human   391 CFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448
            ||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 CFIAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNLVRPFMDTLASHQLYI 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSEN2	NP_000438.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70		60/68 (88%)
		Presenilin	82..438	CDD:460052	343/355 (97%)
		PAL	414..416		1/1 (100%)
Psen2	NP_112349.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		54/60 (90%)
		Presenilin	82..438	CDD:460052	343/355 (97%)
		PAL	414..416		1/1 (100%)