DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gbf1 and garz

DIOPT Version :9

Sequence 1:	XP_009305378.1	Gene:	gbf1 / 566350	ZFINID:	ZDB-GENE-081107-54	Length:	1862	Species:	Danio rerio
Sequence 2:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster

Alignment Length:	1914	Identity:	835/1914 - (43%)
Similarity:	1140/1914 - (59%)	Gaps:	211/1914 - (11%)

- Green bases have known domain annotations that are detailed below.

Zfish     6 IYIVQGEISVVVAAIKRNSRWSTHTPLDEEQDTLLNSFRLLKERLNNIKDLSDVEPNVFLRPFLE 70
            ||:|:||::.::.|::|.:||:....:|:|.|:||..|..||..||.|:||..:||.|||.||||
  Fly     8 IYVVRGEMATLMTAMRRGTRWNATAYVDDENDSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLE 72

Zfish    71 VVRSEDTTGPITGLALTSVNKFLSYGLIDANHEGAAECIENMADAVTHARFVGTDPASDEVVLMK 135
            |:|:.|.|||:|.|||.||||.|||||||......|:.:|.:|||||||||:|||.:||.|..|:
  Fly    73 VIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLADIVERIADAVTHARFMGTDQSSDGVTFMR 137

Zfish   136 ILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFSRLPQFK 200
            :::||.||:.:|.||.::|.|:||:|.|||:|.||.|||||||:|||.:|.|||.|.|.|||||.
  Fly   138 VIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFA 202

Zfish   201 EEAKSYVGTNMKKAYNILWKNKRVQLKMRAGGMSESSKWKKQKRSPRPPRHMVRSPSGQMDPAQS 265
            ||...   |.::|.:.|        ....:|...|..|.|...::...|    |..|...:|.|:
  Fly   203 EERSD---TMLQKRFTI--------GDAASGATQEKLKRKTVAQAQTAP----RKSSAVEEPPQT 252

Zfish   266 STLTNNLSGGVPFIEQHSGGSSTFPGSDSAASSISSPTTDSG--LDTGSKTTSKEDLTDLDQNSS 328
            ....|                .|.||...|....::|.:.:|  ||...|.| :...|.......
  Fly   253 PQSAN----------------LTVPGHLKAPILATTPASPAGNILDMQGKIT-QTPTTTASTGED 300

Zfish   329 TATTPITPSAEPGRLESQSEGRGVERAQSASVESIPEVLEDRDLLADQSDSASVHDMDYVNPRGV 393
            ..|.|.||..:            ||..:|       |.|.|.:.....|..|..:..:|:|..||
  Fly   301 ETTVPETPVIQ------------VESTES-------EPLLDGETGEATSTLAEANSSEYINSVGV 346

Zfish   394 RFT-QSTQKEGAALIPYGLPCLRELFRFLISLTNPHDRHNSDVMMHMGLQLLNVALEAA--HIAP 455
            ||| |||..:..:|.|||||.::|||||||.|.||.|:.|||.|||.||.||.||.|.|  :|..
  Fly   347 RFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCNPLDKQNSDSMMHTGLSLLTVAFEVAADNIGK 411

Zfish   456 YQSLLGLVKDELCRHLIQLLGVDRMNLYTASIRVCFLLFESMREHLKFQLEMYLKKLMDIITSEN 520
            |:.||.||||:|||:||.||..:|::::.|.:::|||||||:|.|||||||.||:||.:||.|:|
  Fly   412 YEGLLELVKDDLCRNLISLLSSERLSIFAADLQLCFLLFESLRGHLKFQLEAYLRKLSEIIASDN 476

Zfish   521 PKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDFYCSNLFEDLTKLLSKNAFPVSGQLYTTHL 585
            ||.||||:|:||:.::||||||.||||||||||||.||:::||.||.||||.....:..:|:||:
  Fly   477 PKTPYEMRELALDNLLQLWRIPGFVTELYINYDCDLYCTDMFESLTNLLSKYTLSATNAVYSTHI 541

Zfish   586 LSLEALLTVIDSTEAHCQAKVLNSATQQEQSESTTVGDSSVSTITDSPAETGKPHPSSN-GQNSV 649
            :|::.||:||||.|.:|.|...:|..::...|:             :||..|..|...| |...:
  Fly   542 ISMDTLLSVIDSIERNCAASKNSSNNRESLPEA-------------APATGGSRHSRHNSGLEGI 593

Zfish   650 VSETRASCPPTSGHLMAEKMRLGRQDQEETDTGEKKISKKPHRF------SSYLPDSQELLEIKN 708
            |.:        ||:.:|.        :|:.:.....|:...||.      ......|::|.::|.
  Fly   594 VID--------SGNSVAA--------EEKVENIASFINASSHRLRLQSGGEGVGITSEQLAKVKQ 642

Zfish   709 KKKLLITGTEQFNQKPKKGIQTLQEKGLLSSPMDNNEVAQWLRENPRLDKKMIGEFISDRRNTD- 772
            ||:||..|||:|||:|:||||.|||.|:|::.:|..:||.:|||||.||||||||:||.::|.|
  Fly   643 KKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMIGEYISKKKNVDS 707

Zfish   773 -LLDSFVNTFTFQGLRIDEALRLYLEAFRLPGEAPVIHRLLETFTDNWHKVNGNPFQTNDAGFAL 836
             :|.:||::|.|.|||:|:|||||||.||||||||:|..:||.|:|:|||.|.:||...||.|.|
  Fly   708 KILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHWHKQNQDPFANVDAAFRL 772

Zfish   837 AYAVIMLNTDQHNHNVRKQNIPMTLEQFKKNLKGVNGGNDFDQDMLEDIYNAIKNEEIVMPDEQT 901
            |||:||||.||||.|.::.|:|||||.|.|||:|:|||.||||:||..::|||||||||||.|||
  Fly   773 AYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQEMLAQVFNAIKNEEIVMPAEQT 837

Zfish   902 GLVKENYVWSVLLHRGASAEGMFLHVPDGSYDRDLFSMTWGPTIAALSYVFDKSLDDTIIEKAIA 966
            |||:|||.|.|||.||.:.:|.|.:|.|.|||.::|::.||.:::|||::|||| .:|..::.:|
  Fly   838 GLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDKS-TETGYQRTLA 901

Zfish   967 GFRKCAMISAHYGFSDVFDNLIISLCKFTTLSSESVENLPTV----------FGSNRKAQVAAKT 1021
            ||.|.|.|||||.....||.|:::|||||||.|...::.|..          ||.|.|||.|.:|
  Fly   902 GFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGLNGKAQAAMRT 966

Zfish  1022 VFSLAHRHGDILRDGWKNIMDSMLQLFRAELLPKTMVEVEDFLDPNEKISLQREETPSNRGESAV 1086
            ||.|.|.:||.||:.||:|:|..|||||.:||||:::|||||.:.|.|..|..|: |..:.||.:
  Fly   967 VFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSLIEVEDFCEANGKAMLILEK-PREKQESGL 1030

Zfish  1087 LSFVSWLTLSEQSGLRGPSTENQEAKQAALLCIKQCDPEKLNTESKFLQLESLQELMKALISVTP 1151
              |.|..:.....|.|.|:.|.|:..:....|||:|..:::..||||:||||||||:|.::::..
  Fly  1031 --FSSLYSFISSEGQREPTYEEQDFIKLGRKCIKECQLDQMLQESKFVQLESLQELLKCVLALLK 1093

Zfish  1152 DEE-------TYDEEDAAFCLEMLLRIILENRDRVSCVWQTVRDHLYQLCVHANESC---FLVER 1206
            ..:       .|.|:...|.:|.|::|::.||||:..:|..|||.:| |.:..:.||   :|:.|
  Fly  1094 APQGHKSIGLPYAEDQTVFWMEFLVKIVVHNRDRMIPLWPAVRDQMY-LLLMGSASCGYDYLLNR 1157

Zfish  1207 AVVGLLRLAIRLLRREDIGSQVLLSLRLLLMMKPHVLSRVSREVAYGLHELLKTNAANIHSTDDW 1271
            .:|.:|:|||.|:|.|::...||.||::|||:||.:|.|:|::::.|::|||||:|.||||..||
  Fly  1158 CIVAVLKLAIYLMRNEELCPIVLQSLKMLLMLKPALLLRISKQISIGIYELLKTSAQNIHSEQDW 1222

Zfish  1272 YTLFSLLECIGAGIKPP----AALQFANTNPDNDTGAQSDSELSSYHQSEVSLDRGYTSDSEIYN 1332
            ..:|:||||:|||..||    |.|..    |.|.: |:||..:|....:....:|||||||||..
  Fly  1223 QIIFNLLECVGAGAVPPNYDDAQLPL----PPNGS-AKSDGAISGEEDATAVPERGYTSDSEITK 1282

Zfish  1333 EHGKSRIPRSATDVDVGWLVVGKDDLDGAKAAVTTPSKPMNHPLVNQYSL-TLGQDMGL--HDTK 1394
               .|..|..::.....|::|...|     :.:||.|:|.:.|.::...: ||..:..|  |...
  Fly  1283 ---ASAAPAVSSPSAENWILVNNKD-----SELTTASRPQSPPSLSAPPVNTLVYNCQLLDHAPF 1339

Zfish  1395 SLIKCVDSLSFIVRDAAHVTPENFELCVKAIRVFVEASLNGGYRTHEKKKSHKYDSKSSRLRKKP 1459
            :|.||.|||:||||..||:||.|||.||:.||:||||..:||.|...|.:|   .:|....:|:.
  Fly  1340 ALFKCWDSLAFIVRSVAHITPYNFEACVRCIRIFVEACRDGGIRQRRKLES---AAKQKSSKKRS 1401

Zfish  1460 REKEG-ASRRTKASSQRPARSHSDDE------EEEGVPASYHTVSFQVSLDLLDLMHTLHTRAAG 1517
            ..|.| ||..:.::........||::      |:|.:...|.    |:|:.|||||:||:||.|.
  Fly  1402 ERKPGMASSASSSNLTLLTGDPSDNQINGNAAEQEDLAQRYE----QLSIQLLDLMYTLYTRTAQ 1462

Zfish  1518 IYSSWAEEQRHLEDAGKKIEADSQTLWTSCWCPLLQGMAWLCCDARRQVRMQALTYL-QRALLVH 1581
            |:..||||       |..: ..|..||:..|||||||:|.|..|.||:||..|::.| |||||||
  Fly  1463 IFRWWAEE-------GCTV-PQSAALWSPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVH 1519

Zfish  1582 DLQTLDAVEWESCFNKVLFPLLTKLLENISPA---DVGGMEETRMRACTLLSKVFLQHLSPLLSL 1643
            |||||...||.|||::||||||.:||...:.|   |...:||:|:|..|::||||||||:.|:.|
  Fly  1520 DLQTLSGTEWCSCFHQVLFPLLNELLPESNAAGQLDAALLEESRIRTATIMSKVFLQHLTTLIEL 1584

Zfish  1644 -PTFAALWLTILDFMDKYMHAGSSDLLLEAIPESLKNMLLVMDTAGIFHSADSRTGYSDLWEITW 1707
             ..|..|||.|||:::::|..| ||.|.|.:.|.||||||||.:..:||:.|.....: |||:||
  Fly  1585 GNAFNELWLDILDYIERFMKVG-SDTLSEQMQEILKNMLLVMHSVRVFHNQDGSLQQA-LWELTW 1647

Zfish  1708 ERIVCFLPRLKEELFKQAVIPEPVCNVPVEPVPPPVAVPPAAPTVPAPSPVPAAPAEPNIPSRPS 1772
            .||..|||.||||||...                    ...|.|:..|:|..|..|.|.
  Fly  1648 RRIGEFLPNLKEELFHDE--------------------GKRAQTLTNPAPQAAVAAAPQ------ 1686

Zfish  1773 SPQDMPTPSANGDRTDRSSP--VPPSTPPLPTPAKKSPPESPPPLSQSPLILQ-PLASPLQVGVP 1834
              |.:|..:....:|..|:.  |...|||..||...||.|||    :..:||| |:|..||  .|
  Fly  1687 --QQLPAVTILPRQTQVSNELVVSAPTPPAATPLLGSPVESP----RRSIILQPPMADVLQ--QP 1743

Zfish  1835 P---MTLPIILNPALIEATSPVP---LLP 1857
            |   ...|||:.|.....|.|:|   |||
  Fly  1744 PSFVFAQPIIVPPQPPAVTDPIPPSTLLP 1772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gbf1	XP_009305378.1	Sec7_N	410..555	CDD:289549	93/146 (64%)
		COG5307	493..>1170	CDD:227623	336/702 (48%)
		Sec7	709..894	CDD:279680	117/186 (63%)
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	373/748 (50%)
		Sec7_N	370..512	CDD:289549	91/141 (65%)
		Sec7	643..830	CDD:279680	117/186 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582816
Domainoid	1	1.000	641	1.000	Domainoid score	I157
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37897
Inparanoid	1	1.050	1354	1.000	Inparanoid score	I130
OMA	1	1.010	-	-		QHG55524
OrthoDB	1	1.010	-	-		D49474at33208
OrthoFinder	1	1.000	-	-		FOG0003083
OrthoInspector	1	1.000	-	-		oto39280
orthoMCL	1	0.900	-	-		OOG6_102130
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2055
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770