Protein Alignment PSEN1 and Psn

DIOPT Version :10

• Sequence 1: NP_000012.1
• Gene: PSEN1 / 5663
• HGNCID: 9508
• Length: 467
• Species: Homo sapiens
• Sequence 2: NP_524184.1
• Gene: Psn / 40260
• FlyBaseID: FBgn0284421
• Length: 541
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 252/528 - (47%)
• Similarity: 325/528 - (61%)
• Gaps: 79/528 - (14%)

Human    17 SED-----NHLSNTVRSQNDNRERQEHNDRRSLGHPEPLS--------------NGRPQ----GN 58
            |||     :.:....|.:...|.:|:.|:..|....:|.:              ..||.    |.
  Fly    16 SEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRPSRLTGGG 80

Human    59 SRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTE 123
            .........|.:||..|||||:|||.|||||:|||:||||||.|:|||...|..|:||||.|.:.
  Fly    81 GGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYTPFHEQSP 145

Human   124 TVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKT 188
            ....:...::.|:.|::||:||||.||:||||.|||::||.|||:||.:|||.|:::||.|:.:.
  Fly   146 EPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRA 210

Human   189 YNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVI 253
            ||:.:||.|..|::||||||||:||||:|||||||.|||.::|||||||||||||||||.:||.|
  Fly   211 YNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAI 275

Human   254 SVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVW-LVNMAEGDPEAQRRVSKNSKYNA 317
            |::||:|||.|:||||:||||||||||.:|||||||||:|: |||............|..|..|:
  Fly   276 SIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNS 340

Human   318 ESTERESQDTVA--------------------ENDDG------------------------GFSE 338
            .:|.|.:|:::|                    :.|||                        ||::
  Fly   341 TTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRGNAEAAGFTQ 405

Human   339 EWEAQRDSHLGPH----RSTPESRAAVQELSSSILAGED-----PEERGVKLGLGDFIFYSVLVG 394
            ||.|.....:...    :||....|.......::.|.:.     .||||:|||||||||||||||
  Fly   406 EWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVG 470

Human   395 KASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQ 459
            |||  :.|||.||||||||||||||||||||||::||||||||||||||:|.|||..:|:|||:.
  Fly   471 KAS--SYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMED 533

Human   460 LAFHQFYI 467
            |:..|.:|
  Fly   534 LSAKQVFI 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSEN1	NP_000012.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..68		12/73 (16%)
		Presenilin	76..457	CDD:460052	231/434 (53%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..333		7/47 (15%)
		Required for interaction with CTNNB1. /evidence=ECO:0000269|PubMed:9738936	322..450		79/180 (44%)
		Required for interaction with CTNND2. /evidence=ECO:0000269|PubMed:10037471	372..399		22/31 (71%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	377..381		2/3 (67%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	432..434		1/1 (100%)
		PAL. /evidence=ECO:0000305|PubMed:16305624	433..435		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000269|PubMed:10551805	464..467		1/2 (50%)
Psn	NP_524184.1	Presenilin	98..531	CDD:460052	231/434 (53%)