Protein Alignment PSEN1 and psen1

DIOPT Version :10

• Sequence 1: NP_000012.1
• Gene: PSEN1 / 5663
• HGNCID: 9508
• Length: 467
• Species: Homo sapiens
• Sequence 2: XP_031746154.1
• Gene: psen1 / 394924
• XenbaseID: XB-GENE-481916
• Length: 490
• Species: Xenopus tropicalis
• Alignment Length: 465
• Identity: 366/465 - (78%)
• Similarity: 397/465 - (85%)
• Gaps: 12/465 - (2%)

Human     4 LPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEE 68
            ||..|...|..:...||..:|    .||.      |:|||..|.|..|||:.|.:|:||:|||||
 Frog    37 LPGRLQQIQETEDFTDNRPAN----MNDT------NERRSNEHSESQSNGQTQSSSQQVLEQDEE 91

Human    69 EDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSI 133
            ||||||||||||||||||||||||||||||||||||||||.|||||||||||||::||||||:||
 Frog    92 EDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRYDGQLIYTPFTEDTDSVGQRALNSI 156

Human   134 LNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITV 198
            ||.|||||||:|||||||||||||||||||.||||||||||||||:|||||||||||||:||||:
 Frog   157 LNTAIMISVIIVMTILLVVLYKYRCYKVIHGWLIISSLLLLFFFSYIYLGEVFKTYNVAMDYITL 221

Human   199 ALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLC 263
            ||:||||||||||.|||||||.|||||||||||||||||||||||||.||||||||||||:|||.
 Frog   222 ALMIWNFGVVGMICIHWKGPLLLQQAYLIMISALMALVFIKYLPEWTTWLILAVISVYDLIAVLS 286

Human   264 PKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAES-TERESQDT 327
            |||||||||||||||||||||||||||||:|||.||:|||..::..||.: |||:: ..:...|:
 Frog   287 PKGPLRMLVETAQERNETLFPALIYSSTMIWLVKMADGDPGFKQSASKKT-YNAQAPVAQPRSDS 350

Human   328 VAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVL 392
            .|.:|:|||...||.||:..:|...||||||||||.|.|:....|||||||||||||||||||||
 Frog   351 AASDDNGGFDTAWEEQRNEQIGQINSTPESRAAVQALPSNNPPSEDPEERGVKLGLGDFIFYSVL 415

Human   393 VGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFM 457
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   416 VGKASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFM 480

Human   458 DQLAFHQFYI 467
            ||||||||||
 Frog   481 DQLAFHQFYI 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSEN1	NP_000012.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..68		21/54 (39%)
		Presenilin	76..457	CDD:460052	320/381 (84%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..333		7/28 (25%)
		Required for interaction with CTNNB1. /evidence=ECO:0000269|PubMed:9738936	322..450		99/127 (78%)
		Required for interaction with CTNND2. /evidence=ECO:0000269|PubMed:10037471	372..399		26/26 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	377..381		3/3 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	432..434		1/1 (100%)
		PAL. /evidence=ECO:0000305|PubMed:16305624	433..435		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000269|PubMed:10551805	464..467		2/2 (100%)
psen1	XP_031746154.1	Presenilin	99..480	CDD:460052	320/381 (84%)