Protein Alignment PSEN1 and psen1

DIOPT Version :10

• Sequence 1: NP_000012.1
• Gene: PSEN1 / 5663
• HGNCID: 9508
• Length: 467
• Species: Homo sapiens
• Sequence 2: NP_571099.1
• Gene: psen1 / 30221
• ZFINID: ZDB-GENE-991119-4
• Length: 456
• Species: Danio rerio
• Alignment Length: 463
• Identity: 334/463 - (72%)
• Similarity: 367/463 - (79%)
• Gaps: 19/463 - (4%)

Human    12 QNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVV-EQDEEEDEELTL 75
            |||..:..|...:|.|..:........|:....|.|       |.....||| :.:|:|||||||
Zfish     6 QNAANNVLNDGMDTSRHTSSTAAPPSRNEVELNGQP-------PTAPPPQVVTDSEEDEDEELTL 63

Human    76 KYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDG-QLIYTPFTEDTETVGQRALHSILNAAIM 139
            |||||||||||:||||||||||||||||||||:||| |||||||.|||||||||||||:|||.||
Zfish    64 KYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTQKDGQQLIYTPFREDTETVGQRALHSMLNAIIM 128

Human   140 ISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWN 204
            ||||||||::|||||||||||||.|||..|:||||||||.|||||||||||||:||.|:||:|||
Zfish   129 ISVIVVMTLVLVVLYKYRCYKVIQAWLFFSNLLLLFFFSLIYLGEVFKTYNVAMDYFTLALIIWN 193

Human   205 FGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLR 269
            |||||||.|||||||||||||||||||||||||||||||||||||||.||||||:||||||||||
Zfish   194 FGVVGMICIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAAISVYDLLAVLCPKGPLR 258

Human   270 MLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERE---SQDTVAEN 331
            :||||||||||.:|||||||||||||.|||:   .|:.|  .||.:.....|.:   ...|....
Zfish   259 ILVETAQERNEAIFPALIYSSTMVWLFNMAD---SAETR--NNSSHPVPQQENQVVAMAPTAQAE 318

Human   332 DDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSS--ILAGEDPEERGVKLGLGDFIFYSVLVG 394
            |||||:..|...:...|||.:||.|||..:||:.|:  ....:|.||||||||||||||||:|||
Zfish   319 DDGGFTPAWVDHQQHQLGPMQSTEESRRQIQEMPSARPPPPADDDEERGVKLGLGDFIFYSMLVG 383

Human   395 KASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQ 459
            |||||||||||||:||||||||||||||||||||||||||||||||||||||||||.||:|||||
Zfish   384 KASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDNLVRPFMDQ 448

Human   460 LAFHQFYI 467
            ||.|||||
Zfish   449 LAVHQFYI 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSEN1	NP_000012.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..68		12/55 (22%)
		Presenilin	76..457	CDD:460052	302/386 (78%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..333		6/30 (20%)
		Required for interaction with CTNNB1. /evidence=ECO:0000269|PubMed:9738936	322..450		91/132 (69%)
		Required for interaction with CTNND2. /evidence=ECO:0000269|PubMed:10037471	372..399		23/26 (88%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	377..381		3/3 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	432..434		1/1 (100%)
		PAL. /evidence=ECO:0000305|PubMed:16305624	433..435		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000269|PubMed:10551805	464..467		2/2 (100%)
psen1	NP_571099.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..56		10/53 (19%)
		Presenilin	64..446	CDD:460052	302/386 (78%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	277..279		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..365		12/32 (38%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	366..370		3/3 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	421..423		1/1 (100%)
		PAL. /evidence=ECO:0000305	422..424		1/1 (100%)