Protein Alignment PSEN1 and Psen1

DIOPT Version :10

• Sequence 1: NP_000012.1
• Gene: PSEN1 / 5663
• HGNCID: 9508
• Length: 467
• Species: Homo sapiens
• Sequence 2: NP_062036.2
• Gene: Psen1 / 29192
• RGDID: 3425
• Length: 468
• Species: Rattus norvegicus
• Alignment Length: 469
• Identity: 433/469 - (92%)
• Similarity: 452/469 - (96%)
• Gaps: 3/469 - (0%)

Human     1 MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGN-SRQVVE 64
            |||:|||||||||||||||:| |::|||||||:|||:|:||:.|.:||.:||||||.| :|||:|
  Rat     1 MTEIPAPLSYFQNAQMSEDSH-SSSVRSQNDNQERQQHHDRQRLDNPESISNGRPQSNFTRQVIE 64

Human    65 QDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRA 129
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    65 QDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRA 129

Human   130 LHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVD 194
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
  Rat   130 LHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIVSSLLLLFFFSFIYLGEVFKTYNVAVD 194

Human   195 YITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLV 259
            |||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   195 YITVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLV 259

Human   260 AVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTER-E 323
            ||||||||||||||||||||||||||||||||||||||||||||||||||.||.||:.:.||| |
  Rat   260 AVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVPKNPKYSTQGTEREE 324

Human   324 SQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIF 388
            :|||...:||||||||||||||||||||||||||||||||||.|||..|||||||||||||||||
  Rat   325 TQDTGTGSDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSGSILTSEDPEERGVKLGLGDFIF 389

Human   389 YSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLV 453
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
  Rat   390 YSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLIFYFATDYLV 454

Human   454 QPFMDQLAFHQFYI 467
            ||||||||||||||
  Rat   455 QPFMDQLAFHQFYI 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSEN1	NP_000012.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..68		38/55 (69%)
		Presenilin	76..457	CDD:460052	363/381 (95%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..333		16/28 (57%)
		Required for interaction with CTNNB1. /evidence=ECO:0000269|PubMed:9738936	322..450		118/128 (92%)
		Required for interaction with CTNND2. /evidence=ECO:0000269|PubMed:10037471	372..399		26/26 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	377..381		3/3 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	432..434		1/1 (100%)
		PAL. /evidence=ECO:0000305|PubMed:16305624	433..435		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000269|PubMed:10551805	464..467		2/2 (100%)
Psen1	NP_062036.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		42/57 (74%)
		Presenilin	76..458	CDD:460052	363/381 (95%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..338		21/33 (64%)
		Required for interaction with CTNNB1. /evidence=ECO:0000250|UniProtKB:P49768	322..451		118/128 (92%)
		Required for interaction with CTNND2. /evidence=ECO:0000250|UniProtKB:P49768	373..400		26/26 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	378..382		3/3 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	433..435		1/1 (100%)
		PAL. /evidence=ECO:0000305	434..436		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000250|UniProtKB:P49768	465..468		2/2 (100%)