Protein Alignment PSEN1 and Psen1

DIOPT Version :10

• Sequence 1: NP_000012.1
• Gene: PSEN1 / 5663
• HGNCID: 9508
• Length: 467
• Species: Homo sapiens
• Sequence 2: NP_001349200.1
• Gene: Psen1 / 19164
• MGIID: 1202717
• Length: 467
• Species: Mus musculus
• Alignment Length: 467
• Identity: 433/467 - (92%)
• Similarity: 451/467 - (96%)
• Gaps: 0/467 - (0%)

Human     1 MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQ 65
            |||:|||||||||||||||:|.|:.:|||||::|||:.:||:.|.:|||:||||||.||||||||
Mouse     1 MTEIPAPLSYFQNAQMSEDSHSSSAIRSQNDSQERQQQHDRQRLDNPEPISNGRPQSNSRQVVEQ 65

Human    66 DEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRAL 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 DEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRAL 130

Human   131 HSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDY 195
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 HSILNAAIMISVIVIMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDY 195

Human   196 ITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVA 260
            :|||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 VTVALLIWNFGVVGMIAIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVA 260

Human   261 VLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQ 325
            |||||||||||||||||||||||||||||||||||||||||||||||||.||.|||.:..|||:|
Mouse   261 VLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVPKNPKYNTQRAERETQ 325

Human   326 DTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYS 390
            |:.:.|||||||||||||||||||||||||||||||||||.|||..|||||||||||||||||||
Mouse   326 DSGSGNDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSGSILTSEDPEERGVKLGLGDFIFYS 390

Human   391 VLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQP 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 VLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQP 455

Human   456 FMDQLAFHQFYI 467
            ||||||||||||
Mouse   456 FMDQLAFHQFYI 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSEN1	NP_000012.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..68		38/54 (70%)
		Presenilin	76..457	CDD:460052	363/380 (96%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..333		16/27 (59%)
		Required for interaction with CTNNB1. /evidence=ECO:0000269|PubMed:9738936	322..450		119/127 (94%)
		Required for interaction with CTNND2. /evidence=ECO:0000269|PubMed:10037471	372..399		26/26 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	377..381		3/3 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000269|PubMed:30598546	432..434		1/1 (100%)
		PAL. /evidence=ECO:0000305|PubMed:16305624	433..435		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000269|PubMed:10551805	464..467		2/2 (100%)
Psen1	NP_001349200.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68		49/66 (74%)
		Presenilin	76..457	CDD:460052	363/380 (96%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	288..290		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..357		41/52 (79%)
		Required for interaction with CTNNB1. /evidence=ECO:0000250|UniProtKB:P49768	322..450		119/127 (94%)
		Required for interaction with CTNND2. /evidence=ECO:0000250|UniProtKB:P49768	372..399		26/26 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	377..381		3/3 (100%)
		Important for cleavage of target proteins. /evidence=ECO:0000250|UniProtKB:P49768	432..434		1/1 (100%)
		PAL	433..435		1/1 (100%)
		Interaction with MTCH1. /evidence=ECO:0000250|UniProtKB:P49768	464..467		2/2 (100%)