Protein Alignment ASAH2 and CDase

DIOPT Version :10

• Sequence 1: NP_063946.2
• Gene: ASAH2 / 56624
• HGNCID: 18860
• Length: 780
• Species: Homo sapiens
• Sequence 2: NP_651797.1
• Gene: CDase / 43618
• FlyBaseID: FBgn0039774
• Length: 704
• Species: Drosophila melanogaster
• Alignment Length: 697
• Identity: 307/697 - (44%)
• Similarity: 425/697 - (60%)
• Gaps: 41/697 - (5%)

Human   102 YHIGVGRADCTGQVADINLMGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSIDIGMVSQR 166
            |.:||||||.||...:||.|||....|..:||.||:::|||::.:..| ||..|||.|.||:...
  Fly    25 YKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVVEDEKG-NRVAFVSADAGMMGYG 88

Human   167 LRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKSI 231
            |:.||:.|||::||::|..|||.:||||||..|.|:..:.::.|:..||..|||:.|..|:...|
  Fly    89 LKREVIKRLQARYGNIYHNDNVAISGTHTHGAPGGFLMHLLYDISILGFVPQTFEVMAQGLYLCI 153

Human   232 DIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLNGDDLGL 296
            ..|..|:..|:|.::|..|..|.|||||.|||:||..|||:|..:|||.:..|:.|||..:.||.
  Fly   154 KRATDNLVDGRILLSKTTVLNVNINRSPSSYLRNPAEERAQYEHDTDKTLTQLRFVDLENNLLGA 218

Human   297 ISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVAAFASSNLGDVSPNILGPR 361
            .:|:|:|..||||:|.||.|||||||:.|||:|.|...:||:|.||.||.|||||||||||:||:
  Fly   219 FNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPGKGKFVGAFCSSNLGDVSPNIMGPK 283

Human   362 CINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRAMYQRA-----KELYASASQEVTG 421
            |..:|..||...|.||. |...|.|.|||:|||:||||:|:.:...|     ::...|.::||||
  Fly   284 CSISGNECDLLTSRCPT-GEGDCFASGPGKDMFESTQILGQRLADAALGLLNEQSQESTAREVTG 347

Human   422 PLASAHQWVDMTDVTVWLNSTH--------ASKTCKPALGYSFAAGTIDGVGGLNFTQGKTEGDP 478
            .:...||:|||.:   :..||:        ..:.|:||:||||||||.||.|..:|.||.|..:|
  Fly   348 DVRFIHQFVDMPN---YNGSTYNPLSRKVDKIRGCQPAMGYSFAAGTTDGPGAFSFEQGTTTDNP 409

Human   479 FWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVDVQIITLGSLAITAIPGEFTT 543
            .|:.:||.|.....|:|| ||:||||||.||..:.|:.|.|.||..|::.:|.:.|.|:|.||||
  Fly   410 MWNFVRDFIAAPTQEDIK-CHEPKPILLATGRATFPYEWQPKIVSDQLLKIGDVIIAAVPCEFTT 473

Human   544 MSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQ 608
            |:|||||..::|..::.|..:..|:|:||.|:||.|..|.||||||||||||||:||||.|.|:.
  Fly   474 MAGRRLRNQIRAAASAVGGIDTEVIIAGLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSIYMD 538

Human   609 LFRNLAKA-IATDTVANLSRGPEPPFFKQLIVPLIPSIV-DRAPKGRTFGDVLQPAKPEYRVGEV 671
            :|..|.|| :..:||   ..||.||:...:::.|...:: |..|....||.|......||.:.|.
  Fly   539 VFERLTKAMMRNETV---DAGPSPPYMNDVMLSLNTGVLFDGHPINTDFGYVKSQPNKEYGINET 600

Human   672 AEVIFVGANPKNSVQNQTHQTFLTVEKYEATSTSWQIVCNDASWETRFYWHK--GLLGLSNATVE 734
            .:|.::..||:|::  .|.:|:.|:|: :.....|::...||||||:..||:  .:||.|...:.
  Fly   601 VKVTYISGNPRNNL--FTEKTYFTIER-KINEDRWKVAYTDASWETKMVWHRTNTILGFSEMDIY 662

Human   735 WHIPDTAQPGIYRIRYFGHNRKQDILKPAVILS----FEGTSPAFEV 777
            |.|.....||.||||:.|..:        .||.    :||.:.:|.|
  Fly   663 WDISPQTLPGEYRIRHSGEYK--------YILGGKYPYEGLTHSFTV 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASAH2	NP_063946.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	47..90
		Ceramidase_alk	102..608	CDD:461415	253/518 (49%)
		Ceramidse_alk_C	610..777	CDD:465340	53/174 (30%)
		Required for correct folding and localization. /evidence=ECO:0000250|UniProtKB:Q91XT9	770..780		3/8 (38%)
CDase	NP_651797.1	Ceramidase_alk	25..538	CDD:461415	253/518 (49%)
		Ceramidse_alk_C	540..701	CDD:465340	53/174 (30%)