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Protein Alignment PSD and Efa6

DIOPT Version :10

Sequence 1:	NP_002770.3	Gene:	PSD / 5662	HGNCID:	9507	Length:	1024	Species:	Homo sapiens
Sequence 2:	NP_001163691.2	Gene:	Efa6 / 42665	FlyBaseID:	FBgn0051158	Length:	1601	Species:	Drosophila melanogaster

Alignment Length:	837	Identity:	286/837 - (34%)
Similarity:	407/837 - (48%)	Gaps:	165/837 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   229 SSHAQRIARAKWEFFYGSLDPPSSGAKPPEQAPPSPPGVG----SRQGSGVAVGRAAKYSETDLD 289
            :||:..|:.:......||              |.||..|.    |..||..|:|..:.      .
  Fly   887 NSHSSSISSSPQHSAVGS--------------PASPTSVSSSVMSSSGSKGALGLGSS------S 931

Human   290 TVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDD 354
            ..|:...::    :.|.|||:....  :||.| |.||....|....|...|.....|.||.|:..
  Fly   932 NGPMAAVQQ----QQLREREQGGQV--AQPPS-GIPGLLSCPGGGCGNNGGGGGIGGGGNNDQSV 989

Human   355 DEA----GGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRA 415
            .||    ...:..||:...:|.....|  |.|..|             .||.|.:..:...:|:.
  Fly   990 SEAISNISSPDYQDDDNLLSSRDILGG--MVLSDP-------------SDSDSTILVSDAAAHQR 1039

Human   416 KGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ 480
            :                          :|..|..|.:..                         |
  Fly  1040 Q--------------------------QLKQQLRAQQQQ-------------------------Q 1053

Human   481 RGEE-------EEAEARAKL--------APGREPPSPCHSEDSLGLGAAPLG--------SEPPL 522
            |..|       |::|.:..:        :.|....:....||.:.|...|||        :.||
  Fly  1054 RERERDRDRDREQSEHKVVIQVRGLDSNSSGGNGTNGRSEEDVVTLTDEPLGTMTVGMRDASPP- 1117

Human   523 SQLVSDSDSELDSTERLALGSTDTLSNGQKA-DLEAAQRLAKRLYRLDGFRKADVARHLGKNNDF 586
               |||..|:::|..        :.....|| |:.:|.||||||:.||||:|:||:|||.|||||
  Fly  1118 ---VSDDGSDVESLH--------SYHYSPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSKNNDF 1171

Human   587 SKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAH 651
            |:.||.||||.|.|...:||||||.||::.:|.||||||||||.|||:|:..|||...:|:|..|
  Fly  1172 SRAVADEYLKHFTFEKKSLDQALREFLQQFSLSGETQERERVLVHFSKRFLDCNPGTFNSQDAVH 1236

Human   652 TLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEE- 715
            |||||:|||||||||.||.::|:|.:|:.||..||||.:||:::||:||.:||.:.|:||:|||
  Fly  1237 TLTCAIMLLNTDLHGQNINRKMSCAEFVDNLADLNDGENFPKDVLKSLYQAIKTKPLEWALDEEA 1301

Human   716 ----ELRRSLSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAV-YKHGALVRKVHADPDCRK 775
                :.|.:.|.|.:              .|.:|||| .||...|| ||.|.::||...|...:|
  Fly  1302 GDLQQQRANNSALGN--------------VGLNPFLD-PPELATAVEYKKGYVMRKCCYDSSFKK 1351

Human   776 TPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR 840
            ||.|||.||.|:..|:.::|||.|:|:...|:.....|.|||.|||||||:|:||:|:.|||.|:
  Fly  1352 TPFGKRSWKMFYCTLRDLVLYLHKDEHGFRKSQMSDNLHNAIRIHHALATKANDYTKKQHVFRLQ 1416

Human   841 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVR 905
            |||...:|||....:::|||:..||.|.|..||||....|.|||:|.||||||..::|..:||:.
  Fly  1417 TADQAEYLFQTSDSKELQSWVETINYVCAAISAPPLEGGVGSQKRFQRPLLPSKQSKLMLKEQLD 1481

Human   906 THEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLRVKLKAGSEEL 970
            :||.:|..:..||.||:...:..||..  .:..::||:||::|..||.||.::|..|:.|..::|
  Fly  1482 SHEVQLAQLDQELNEHKKGPIPSKGLA--LQNYKEKESYLQYELRRYRTYVSILSAKMLADQQQL 1544

Human   971 DAVEAALAQAGSTEDGLP--PSHSSPSLQPKPSS--QPRAQRHSSEPRPGAGSGRRK 1023
            : ::|......|.|:...  |..::....|.|.|  |...|:...:.:|.....::|
  Fly  1545 E-LQAQQPSPASHEEEADTFPVGTTACTPPTPQSINQKDQQKEQQQQQPTNRKEKKK 1600

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.