DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rps6ka4 and S6k

DIOPT Version :9

Sequence 1:	NP_064308.2	Gene:	Rps6ka4 / 56613	MGIID:	1930076	Length:	773	Species:	Mus musculus
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	193/396 - (48%)
Similarity:	255/396 - (64%)	Gaps:	19/396 - (4%)

- Green bases have known domain annotations that are detailed below.

Mouse    14 LQITEANLTGHEEKVSVENFALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAKT 78
            :|:.|.|:...:.|:..::|.|.||||.|.|||||.||||.|.||.|.:|||||:||::|...|.
  Fly    58 IQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKD 122

Mouse    79 QEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGG 143
            ..|||.||::||.|:. ||:|.|.||||||.||:|||:|:||||:|.||.:...|.|.....|..
  Fly   123 TAHTRAERNILEAVKH-PFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLS 186

Mouse   144 EIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEI 208
            ||:|||.|||||||||||||.||:|||::||:.||||||.||.: :|...|.:||||||||||||
  Fly   187 EIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHI-QEGIVTHTFCGTIEYMAPEI 250

Mouse   209 IRSKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPLRIGPVAQDLL 273
            : :::||||||||||||.|:|::|||..|||.|..:.|    ...|||.....|..:.|.|:||:
  Fly   251 L-TRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKT----IETILKAKLNLPAYLTPEARDLV 310

Mouse   274 QRLLCKDPKKRLGAGPQGAQEVKSHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRL 338
            :||:.:...:|||:||:.|..|:.||||:.::|..:.||::..|.:|.:|||.||..|...|||.
  Fly   311 RRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQ 375

Mouse   339 EPVYSPAGSPPPGDPR-IFQGYSFVAPSILFDHNNAVMADVLQAPGAGYRPGRAAVARSAMMQDS 402
            .||.||..:....... ||||:::||||||.|.:.           |...|.|:.......:.||
  Fly   376 IPVDSPDDTTLSESANLIFQGFTYVAPSILEDMHR-----------ANRMPARSPRRTPRQLPDS 429

Mouse   403 PFFQQY 408
            .|..|:
  Fly   430 SFRLQF 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rps6ka4	NP_064308.2	STKc_MSK2_N	32..364	CDD:270765	176/332 (53%)
		S_TKc	33..301	CDD:214567	151/267 (57%)
		STKc_MSK2_C	404..714	CDD:271082	2/5 (40%)
		S_TKc	417..674	CDD:214567
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..696
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..773
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	174/327 (53%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	174/327 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.880