Protein Alignment gmip and cv-c

DIOPT Version :9

• Sequence 1: XP_694162.5
• Gene: gmip / 565801
• ZFINID: ZDB-GENE-130530-823
• Length: 1017
• Species: Danio rerio
• Sequence 2: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Alignment Length: 1181
• Identity: 229/1181 - (19%)
• Similarity: 396/1181 - (33%)
• Gaps: 331/1181 - (28%)

Zfish    18 IPVRH-----SETKRYSEILRD--FDALDLSLKCSTVDELLQEADSLSLPDTSADTTLNADLDDI 75
            :|:.|     .|..:.|.:||.  |.:| ||...:..::|   ...:.||..|: .:|::.|.|.
  Fly  1270 LPIHHHALKSKERGQLSLVLRQEPFQSL-LSPSATAANQL---HHFVELPSPSS-ASLHSGLGDS 1329

Zfish    76 TGEDVEDEVKICREEEEKDEGTLSIAQDADLSLCHCEDGVE---LALQYAKMWC-RYAKDLLTWM 136
            .|..     ::|    .|......:.::.::|  ...|..|   |.|:|::... ||..:
  Fly  1330 GGIQ-----ELC----TKSNSAPMLLKEREMS--RRFDNFEAQHLTLRYSRSQSDRYLAE----- 1378

Zfish   137 DKRISLEQEFAKSIMRAADAAKSCVAQQD-MMPLQNIYTQALEHDLKTSASAKQSAENIQ-QRCY 199
                 :|...|...:|||...:.....:| ..|:          ||...|....:.||.| |..|
  Fly  1379 -----IEAVEACKWLRAAGFPQYAQMYEDHQFPI----------DLNNVAKDHTNLENDQLQSLY 1428

Zfish   200 QALSA-KRNEIDKWRREFKEQWSKEQKRMHDAVSALKR--ARQQYMQRCEEL------------- 248
            :.|.. .|....:..:..|.|..::::...|...||..  ..|.:::|...:
  Fly  1429 RRLCVLNRCATMRLDQSHKPQTPQQKEESDDENFALSEHWTFQPHIRRWSRIGEMGLELPPPGLL 1493

Zfish   249 ----EKAKAMTAKA-----EEDTGGYKTL---------------------DKRRKSRDDAQTKVT 283
                ||.::.:.::     |||..|...:                     |..|..|..::....
  Fly  1494 SLNVEKTESSSKESSPDRFEEDGAGITLVTPGCSKAGGIPNDGSSLGEGSDSGRLRRSGSERIKD 1558

Zfish   284 ETEMQYRQCVSEANNHQKELDKVKRKIIVHIRKLICQGDTVLKEATMKMFNFQRQ-----QTEPV 343
            :.:...|:..|..:..:|..::         ..::..|.|||..:.....:..|:     .|.|.
  Fly  1559 QAKALLRRVESIKSRRRKRQNR---------ENVVISGPTVLDLSQFGQRSSLRKPDAVYSTPPS 1614

Zfish   344 PLAYQNLQLTCAPCEPGEPYLHYILGKRLPDQPPQIYIFQEFIPQNRRSP---PTGRRKQSNIQQ 405
            |.|...:...     |..|:....|  ::|...      ..|:..||.||   ||..|.......
  Fly  1615 PSALSPMHTF-----PKAPFFGNDL--KVPSHS------DNFLSPNRSSPKRTPTTPRSMRTSPL 1666

Zfish   406 DLYALP-DDLKHSSSLVDGRRPGQSDRDSTGSLESLSSPAHGTRKLPKASSTGTMSSDDLDEKDP 469
            ..::.| ..||...|.........|...|||...||..|:...|.|.:   ||.:  ||:.....
  Fly  1667 HFFSSPMSQLKEGKSDDSSSYYSDSQESSTGGKLSLRKPSKARRFLQR---TGKV--DDIGAHSD 1726

Zfish   470 EESEEG----LSDSNGMTC-------------------KPRSASRAALTHRLRKMKSKMVKCKQC 511
            .|..:|    :.|:|..|.                   |.|...|:: :.|.|....|..|..:.
  Fly  1727 SECHQGRKLLIKDANSNTTEVKVKKLTRGGSLNLGKDPKKRDGFRSS-SFRSRSTSRKEAKNDED 1790

Zfish   512 DNYILVNG------------IECEECGLAVHRKC-------------------LEVCQLE----- 540
            ......||            .:.||....:.|||                   :...||:
  Fly  1791 TAGATTNGGSKRQPVVRWHSFQMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKL 1855

Zfish   541 ------------C-EHRRGF--------------------VFGTEFSSLPRETQDSVPFVVLRCT 572
                        | .||.|:                    |||.....:.:.:..::|..|....
  Fly  1856 ALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAF 1920

Zfish   573 EEIENRALGVQGVYRISGSKPRVLKLCQAFEIQKDQVDLSDL----SPHDITSVLKHFFKELPEP 633
            ..::..||...|::|.||.|.|::||.:..|:.....:..|:    ..:|:..:||.:|:||||.
  Fly  1921 RWLQLNALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPES 1985

Zfish   634 LLTFDLYNDFIAVGKEIQRLSEKDHAAESPGIVENIVRRLRELIGRLPVCNNITVQHMMAHLNRV 698
            |||..:...|:|:.:.:            |..|.....:...|:  ||..|...:..::..|..|
  Fly  1986 LLTTKMSETFVAIFQHL------------PAEVRLDAVQCAVLL--LPDENREILYVLLEFLTIV 2036

Zfish   699 AEQFEDNKMSPGNLGIVFGPTLLRPLVS-------------------GDVSMIALLETSYQALLV 744
            |...:.|:|:..|||:....::....:|                   .|:..:|..:.|::.|
  Fly  2037 AANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSASPRRKGKGSGMPDMKELAEAKASHECL-- 2099

Zfish   745 EFMISNYDQVFGSATRSGTPPPPPPTAPLPETPPRATCPVSPSSSSSQDPTATSRERPR------ 803
            .|||.:|.|::.:|...                 .:.|..|....|...|.....|..:
  Fly  2100 SFMIEHYKQIYTAAKEK-----------------LSKCNFSYMEESKPLPLEALGEGMQFHNWRG 2147

Zfish   804 ---SLENRTIK--RDSSEGYISDKSSSNEAMDQLSPEANERAVLAM-SATASPQGLPGQAAENQL 862
               ...:.|||  |:.:.|:.|..|.::.::|....:..:...|.: ..:...:|.|.:..|..:
  Fly  2148 YLYECTSATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVI 2212

Zfish   863 QTRSR--THLSR-QPVKYYRQGSAGAQSRKTSAQLRDENISVSGEGLVSGSADSSRSSSPEPLKT 924
            :.|:.  |:|.: |.||              ....|.|....:.:|.::......||...:..:.
  Fly  2213 KQRASWDTNLLQCQTVK--------------KLDDRTEIYQYALDGQLTTDFCVLRSWQTDLPRG 2263

Zfish   925 LLCLQETVVPQDKTESQTGAHAGVQRTVSQESVQAGASSFVRE--GNTNQSNNTLRGRERLIRSL 987
            ...:.||.:...|.:...||..||          ..||.::.|  |:         ||.|::. |
  Fly  2264 ACVIVETSIDHAKAKPLFGAVRGV----------VLASRYLIEPCGS---------GRSRVMH-L 2308

Zfish   988 RRRSVEEKTSQ 998
            .|..|:.||.:
  Fly  2309 ARVDVKGKTPE 2319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gmip	XP_694162.5	BAR	129..337	CDD:299863	40/255 (16%)
		C1	499..541	CDD:197519	12/89 (13%)
		RhoGAP	549..750	CDD:295372	51/223 (23%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	16/68 (24%)
		RhoGAP_DLC1	1893..2116	CDD:239840	55/238 (23%)
		SRPBCC	2148..2343	CDD:301327	42/206 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030