Protein Alignment KLK6 and alphaTry

DIOPT Version :10

• Sequence 1: NP_002765.1
• Gene: KLK6 / 5653
• HGNCID: 6367
• Length: 244
• Species: Homo sapiens
• Sequence 2: NP_476771.1
• Gene: alphaTry / 48316
• FlyBaseID: FBgn0003863
• Length: 256
• Species: Drosophila melanogaster
• Alignment Length: 260
• Identity: 85/260 - (32%)
• Similarity: 124/260 - (47%)
• Gaps: 28/260 - (10%)

Human     1 MKKLMVVLSLIAAAWA---------EEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLW 56
            |.|::::||.:..|..         :...::|.|.....:|.|:|.:|..||...|||.:.....
  Fly     1 MLKIVILLSAVVCALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANI 65

Human    57 VLTAAHCKKPNLQVFLGKHNLRQRESSQEQSS--VVRAVI----HPDYDAASHDQDIMLLRLARP 115
            ::|||||.:.     :....|:.|..|...||  ||..|.    |..|:|.:...||.::||:..
  Fly    66 IVTAAHCLQS-----VSASVLQVRAGSTYWSSGGVVAKVSSFKNHEGYNANTMVNDIAVIRLSSS 125

Human   116 AKLSELIQPLPLERDCSANTTSCHILGWGKTADG--DFPDTIQCAYIHLVSREEC---EHAYPGQ 175
            ...|..|:.:.|.....||..|..:.|||..:.|  ..|..:|...:::||:.:|   .:.|..|
  Fly   126 LSFSSSIKAISLATYNPANGASAAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQ 190

Human   176 ITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKT 240
            |...|:||...  |||:||||||||||.|..|.|:|||| ..|.....||||.:|....:|:..|
  Fly   191 IRNTMICAAAS--GKDACQGDSGGPLVSGGVLVGVVSWG-YGCAYSNYPGVYADVAVLRSWVVST 252

Human   241  240
              Fly   253  252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLK6	NP_002765.1	Tryp_SPc	23..237	CDD:214473	78/224 (35%)
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	78/226 (35%)