Protein Alignment KLK6 and CG14892

DIOPT Version :10

• Sequence 1: NP_002765.1
• Gene: KLK6 / 5653
• HGNCID: 6367
• Length: 244
• Species: Homo sapiens
• Sequence 2: NP_650562.1
• Gene: CG14892 / 42016
• FlyBaseID: FBgn0038447
• Length: 442
• Species: Drosophila melanogaster
• Alignment Length: 365
• Identity: 90/365 - (24%)
• Similarity: 121/365 - (33%)
• Gaps: 149/365 - (40%)

Human    21 KLVHGGPCDKTSHPYQAA---LYTS----GHLLCGGVLIHPLWVLTAAHCKKPNL---------Q 69
            :::.|...::...|:||:   |:.|    || .||.||||..|:|:||||...:|         .
  Fly    80 RIIAGAATNEGQFPWQASLELLHPSLGFLGH-WCGAVLIHQYWILSAAHCVHNDLFNLPIPPLWT 143

Human    70 VFLGKHNLRQRESSQEQS-SVVRAVIHPDYDAASHDQDIMLLRLARPAKLSE------------- 120
            |.||:|: |..||..||. .|.:.|:|..|....|  |::|::|::||.|:.
  Fly   144 VVLGEHD-RDVESGNEQRIPVEKIVMHHRYHNFKH--DVVLMKLSKPADLTRASNIRRICLPFLL 205

Human   121 ----------------------LIQPLPLE----------------------------------- 128
                                  |||.|.||
  Fly   206 AESPDQAQSETVSPPSSADEDVLIQQLELEDVPEKIDNFLRSVQSRRRYRNVTAPSMKELMNMKI 270

Human   129 ----------------------------------RDCSANT--------------TSCHILGWGK 145
                                              .|.||..              ..|...||||
  Fly   271 LSRMRQALAQRSPRSHKRSRRRNDKLMKLGPRRDSDDSAEQKHPKVSDEPKEIAFVDCVATGWGK 335

Human   146 -TADGDFPDTIQCAYIHLVSREECEHAYPG--QITQNMLCAGDEKYGKDSCQGDSGGPLVC---- 203
             ...||..:.:....:.|.....|..||..  .|....||||.......:|.|||||||.|
  Fly   336 ANISGDLSNQLLKTQVPLHQNGRCRDAYGSFVNIHGGHLCAGKLNGEGGTCVGDSGGPLQCRLSR 400

Human   204 -GDH-LRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTI 241
             |.. |.|:.|:|: .|..:..|.|||....|..||:.||
  Fly   401 DGPWILVGVTSFGS-GCALEGFPDVYTRTSYYMKWIEDTI 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLK6	NP_002765.1	Tryp_SPc	23..237	CDD:214473	86/357 (24%)
CG14892	NP_650562.1	Tryp_SPc	81..438	CDD:238113	88/361 (24%)