Protein Alignment KLK6 and sphe

DIOPT Version :10

• Sequence 1: NP_002765.1
• Gene: KLK6 / 5653
• HGNCID: 6367
• Length: 244
• Species: Homo sapiens
• Sequence 2: NP_573148.2
• Gene: sphe / 32648
• FlyBaseID: FBgn0030774
• Length: 249
• Species: Drosophila melanogaster
• Alignment Length: 253
• Identity: 67/253 - (26%)
• Similarity: 115/253 - (45%)
• Gaps: 18/253 - (7%)

Human     1 MKKLMVVLSLI---AAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAH 62
            |:..:|:|.||   |......|.:::.|...|.|:..:.|:|......:|||.::....:||.||
  Fly     2 MQPRLVILGLIGLTAVGMCHAQGRIMGGEDADATATTFTASLRVDNAHVCGGSILSQTKILTTAH 66

Human    63 CKKPNLQVFLGKHNLRQRESSQEQ------SSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSEL 121
            |...:.:: :....|..|..|..|      .:|....:||||  .:.:.::.::.|:.....::.
  Fly    67 CVHRDGKL-IDASRLACRVGSTNQYAGGKIVNVESVAVHPDY--YNLNNNLAVITLSSELTYTDR 128

Human   122 IQPLPLERD---CSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCA 183
            |..:||...   ..|..:...:.|||:|:||.....|:...:.:.....|..||.....|:...|
  Fly   129 ITAIPLVASGEALPAEGSEVIVAGWGRTSDGTNSYKIRQISLKVAPEATCLDAYSDHDEQSFCLA 193

Human   184 GDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTI 241
            .:.|.|  :|.||.||..:.|:.|.||.::....|||: .|.|:..:..|.:|||:.|
  Fly   194 HELKEG--TCHGDGGGGAIYGNTLIGLTNFVVGACGSR-YPDVFVRLSSYADWIQEQI 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLK6	NP_002765.1	Tryp_SPc	23..237	CDD:214473	56/222 (25%)
sphe	NP_573148.2	Tryp_SPc	42..247	CDD:238113	55/210 (26%)