DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRSS8 and CG9737

DIOPT Version :9

Sequence 1:	NP_002764.1	Gene:	PRSS8 / 5652	HGNCID:	9491	Length:	343	Species:	Homo sapiens
Sequence 2:	NP_651783.1	Gene:	CG9737 / 43600	FlyBaseID:	FBgn0039758	Length:	424	Species:	Drosophila melanogaster

Alignment Length:	305	Identity:	92/305 - (30%)
Similarity:	137/305 - (44%)	Gaps:	70/305 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    37 CGVAPQARITGGSSAVAGQWPWQVSITY-EGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAY---E 97
            ||.....||.||..|...::||...:.| ...:.|.|:|:.::.:|:||||...|..::..   .
  Fly   142 CGKQVTNRIYGGEIAELDEFPWLALLVYNSNDYGCSGALIDDRHILTAAHCVQGEGVRDRQGLKH 206

Human    98 VKLGAHQLDSYSEDAKVSTLKDIIPHPSYL--------------------QEGSQ---GDIALLQ 139
            |:||         :..|.|..|.|..|:||                    :|.|.   .|||:::
  Fly   207 VRLG---------EFNVKTEPDCIEEPNYLSCADAALDIAYEKIHVHPEYKEFSNYKYNDIAIIR 262

Human   140 LSRPITFSRYIRPICLPAANASFP----NGLHCTVTGWGHV----APSVSLLTPKPLQQLEVPLI 196
            |..|::|:.::.|||||  |.|.|    .|...:|:|||..    ...:::.:|..| :|.:|.:
  Fly   263 LKHPVSFTHFVMPICLP--NKSEPLTLAEGQMFSVSGWGRTDLFNKYFINIHSPIKL-KLRIPYV 324

Human   197 SRETCNCL---YNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC--PVEGLWYLTGIV 256
            |.|.|..:   :.:...|::        :||| .|..||.|.|||||||..  .....|...|:|
  Fly   325 SNENCTKILEGFGVRLGPKQ--------ICAG-GEFAKDTCAGDSGGPLMYFDRQHSRWVAYGVV 380

Human   257 SWG-DACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQ 300
            |:| ..||...:|.|||..:.|..||.|        ||.|.::||
  Fly   381 SYGFTQCGMAGKPAVYTNVAEYTDWIDS--------VVQQRKKSQ 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRSS8	NP_002764.1	Tryp_SPc	44..281	CDD:214473	82/277 (30%)
PRSS8	NP_002764.1	Tryp_SPc	45..284	CDD:238113	83/279 (30%)
CG9737	NP_651783.1	CLIP	28..89	CDD:288855
		Tryp_SPc	149..406	CDD:214473	82/277 (30%)
		Tryp_SPc	150..409	CDD:238113	84/287 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910