DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRSS8 and CG16710

DIOPT Version :9

Sequence 1:	NP_002764.1	Gene:	PRSS8 / 5652	HGNCID:	9491	Length:	343	Species:	Homo sapiens
Sequence 2:	NP_651167.3	Gene:	CG16710 / 42790	FlyBaseID:	FBgn0039101	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	290	Identity:	89/290 - (30%)
Similarity:	123/290 - (42%)	Gaps:	69/290 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    37 CG-VAPQARITGGSSAVAGQWPWQVSITYEG----------VHVCGGSLVSEQWVLSAAHCFPSE 90
            || :.|..||.||......:.||...|.|..          |..|.|||::.::||:||||....
  Fly    97 CGPIMPAYRIFGGEETQPNELPWMALILYAHRSRSVWNERLVSRCAGSLITNRYVLTAAHCLRIT 161

Human    91 HHKEAYEVKLGAHQLDSYSE------------------DAKVSTLKDIIPHPSYL--QEGSQGDI 135
             ..:...|:||.|.:.|..:                  |..:|     |.|..|:  :|....||
  Fly   162 -GLDLRRVRLGEHNILSNPDCVTHINGREHCAPEHLEIDVDLS-----IKHRHYMVFEERPYNDI 220

Human   136 ALLQLSRPITFSRYIRPICLPA----ANASFPNGLH-CTVTGWG--HVAPSVSLLTPKPLQQLEV 193
            |||:|..|:.::..|:|||:..    :|.||.|  | ..:.|||  |.....::|       |:.
  Fly   221 ALLRLKFPVRYTAQIKPICVQLDYIFSNPSFSN--HKLQIAGWGLSHKQGYSNVL-------LQA 276

Human   194 PLISRETCNCLYNIDAKPEEPH--FVQEDMVCAGYVEGGKDACQGDSGGPLSCPV----EGLWYL 252
            .:..|....|..:      ||.  ..:|..:|||.: ||.|.|:|||||||...:    |...||
  Fly   277 YVNGRNADECSLS------EPSLGLDKETHICAGNL-GGNDTCKGDSGGPLMAIMERGDEEFVYL 334

Human   253 TGIVSWG-DACGARNRPGVYTLASSYASWI 281
            .||.|:| ..||  ..|..||..|.:..||
  Fly   335 AGITSYGYSQCG--YGPAAYTKTSKFVEWI 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRSS8	NP_002764.1	Tryp_SPc	44..281	CDD:214473	84/280 (30%)
PRSS8	NP_002764.1	Tryp_SPc	45..284	CDD:238113	85/281 (30%)
CG16710	NP_651167.3	CLIP	35..84	CDD:288855
		Tryp_SPc	105..362	CDD:214473	84/280 (30%)
		Tryp_SPc	106..362	CDD:238113	83/279 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910