DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRSS8 and CG30371

DIOPT Version :9

Sequence 1:	NP_002764.1	Gene:	PRSS8 / 5652	HGNCID:	9491	Length:	343	Species:	Homo sapiens
Sequence 2:	NP_610370.1	Gene:	CG30371 / 35806	FlyBaseID:	FBgn0050371	Length:	399	Species:	Drosophila melanogaster

Alignment Length:	309	Identity:	88/309 - (28%)
Similarity:	137/309 - (44%)	Gaps:	51/309 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     8 GPGQLGAVAILLYLGLLRSGTGAEGA-----------EAPCGVAPQARITGGSSAVAGQWPWQVS 61
            |.|.|...::...|......||.:|.           ...||.:...||..|..|.|.::|...:
  Fly   102 GSGTLSRESLFTELVFAYISTGTKGGSFKCTLTTVKQNCNCGWSATTRIANGQQAAANEFPSMAA 166

Human    62 ---ITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVK--------LGAHQL--DSYSEDAK 113
               :|......|||::|:.:::|:||||.        |:|.        :|.:.|  .|.|...:
  Fly   167 LKDVTKNQASFCGGTIVAHRYILTAAHCI--------YQVSRATNIVAIVGTNDLGNPSSSRYYQ 223

Human   114 VSTLKDIIPHPSYLQEGS-QGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCT-VTGWGHV 176
            ...::.:|||..|:.:.. ..|||:|..:..|.:||.:.|||||....|.|...... |.|:|.|
  Fly   224 QYNIQQMIPHEQYVSDPDVNNDIAVLITASNIQWSRGVGPICLPPVGTSTPFTYDLVDVIGYGTV 288

Human   177 ---APSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCA-GYVEGGKDACQGD 237
               .|     |...||::.:.:::.:.|...||..|.      :....:|. .|...|:|:||.|
  Fly   289 FFAGP-----TSTSLQKINLNVVTNQDCQTEYNNVAT------IYTGQMCTYDYSGTGRDSCQFD 342

Human   238 SGGPLSCPVEGLWYLTGIVSWGDACGARNRP-GVYTLASSYASWIQSKV 285
            ||||:... :...:|.||:|:|.:|.....| ||.|..:||.|||:.|:
  Fly   343 SGGPVILR-KSRQFLVGIISYGKSCAESQYPMGVNTRITSYISWIRQKI 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRSS8	NP_002764.1	Tryp_SPc	44..281	CDD:214473	76/256 (30%)
PRSS8	NP_002764.1	Tryp_SPc	45..284	CDD:238113	77/258 (30%)
CG30371	NP_610370.1	CUB	24..>67	CDD:294042
		Tryp_SPc	149..386	CDD:214473	76/256 (30%)
		Tryp_SPc	150..389	CDD:238113	77/258 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910