DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRSS8 and psh

DIOPT Version :9

Sequence 1:	NP_002764.1	Gene:	PRSS8 / 5652	HGNCID:	9491	Length:	343	Species:	Homo sapiens
Sequence 2:	NP_573297.1	Gene:	psh / 32832	FlyBaseID:	FBgn0030926	Length:	394	Species:	Drosophila melanogaster

Alignment Length:	290	Identity:	87/290 - (30%)
Similarity:	140/290 - (48%)	Gaps:	47/290 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    27 GTGAEGAEAPC-----------GVAPQARITGGSSAVAGQWPWQVS---ITYEGVHVCGGSLVSE 77
            |:|...|.|.|           |......|.||.....|.:|...:   ||:.....|||||::.
  Fly   115 GSGDRPAVAACKKIRERKQQRSGNQLVIHIVGGYPVDPGVYPHMAAIGYITFGTDFRCGGSLIAS 179

Human    78 QWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQ-GDIALLQLS 141
            ::||:||||..::.:..|: |:|||..:::.....:...::.:..||.|:  |:: .|||:|:|.
  Fly   180 RFVLTAAHCVNTDANTPAF-VRLGAVNIENPDHSYQDIVIRSVKIHPQYV--GNKYNDIAILELE 241

Human   142 RPITFSRYIRPICL------PAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRET 200
            |.:..:..|||.||      |.:|:.|      .|.||| |....:....|.|.:..:.|:..:.
  Fly   242 RDVVETDNIRPACLHTDATDPPSNSKF------FVAGWG-VLNVTTRARSKILLRAGLELVPLDQ 299

Human   201 CNCLYNIDAKPEEPHFVQ-------EDMVCAGYVEGGKDACQGDSGGPLSCPV---EGLWYLTGI 255
            ||..|     .|:|..::       :.::||...:...|||:|||||||...:   :|::.:.|:
  Fly   300 CNISY-----AEQPGSIRLLKQGVIDSLLCAIDQKLIADACKGDSGGPLIHELNVEDGMYTIMGV 359

Human   256 VSWGDACGARNRPGVYTLASSYASWIQSKV 285
            :|.|..| |...||:||..|||..:|:..|
  Fly   360 ISSGFGC-ATVTPGLYTRVSSYLDFIEGIV 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRSS8	NP_002764.1	Tryp_SPc	44..281	CDD:214473	79/256 (31%)
PRSS8	NP_002764.1	Tryp_SPc	45..284	CDD:238113	80/258 (31%)
psh	NP_573297.1	CLIP	30..79	CDD:197829
		Tryp_SPc	143..384	CDD:214473	79/256 (31%)
		Tryp_SPc	144..387	CDD:238113	80/258 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910