DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lrrc4.1 and Fili

DIOPT Version :9

Sequence 1:	XP_005164844.1	Gene:	lrrc4.1 / 565021	ZFINID:	ZDB-GENE-041210-129	Length:	858	Species:	Danio rerio
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	170/823 - (20%)
Similarity:	285/823 - (34%)	Gaps:	260/823 - (31%)

- Green bases have known domain annotations that are detailed below.

Zfish     7 LLGRVAVRRARKAALLCVLFLMVQACVEVVAAAGPQGCPTDCSC--NNQLSKVVCTRRGLTRVPP 69
            |.|.:.|       ||.:|..:|....|..|.     ||:.|.|  ....|:.:|....|..||.
  Fly    17 LCGAIPV-------LLLLLLTLVILPPETTAF-----CPSKCQCLGGEANSRALCVDAALEDVPI 69

Zfish    70 GIPSTTRHLN-----------------------LMENAIESVQVDSFRNLHHLEVLQLGRNAIRQ 111
            .:...|:::|                       |.:|.||::...:|.....|..|.|.||.:..
  Fly    70 QLNPETKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSS 134

Zfish   112 IEVGAFSGLTNLNTLELFDNRLTVVPSGAFEYLSKLRELWLRNNPIESIPSYAF----------- 165
            :...||.|||||..|:|..||:..|...|...|:.|.||.|.||.|.|:....|
  Fly   135 LHKHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVF 199

Zfish   166 --NR---VP--------SLMRLDLGELRKLEYISDGAFEGLVNLKYLNLGMCNIRGEMPNFTPLV 217
              ||   ||        :|..||: .|..:|::.:.:||||..|..|     :::|.:
  Fly   200 RNNRLLDVPASNLWHLHALKSLDM-SLNLVEFVRNDSFEGLKELLAL-----SVQGNV------- 251

Zfish   218 GLEELEISENLFPEIKPGSFRGLSSLKKLWIMNSQIGLIERNAFDDLASLVELNLAHNNLSSLPH 282
             :.||::|          :|.||.|||.|.:.::.:.::.......|::|..|||..|..|.||.
  Fly   252 -MSELDLS----------AFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPA 305

Zfish   283 DLYTPLKYLVELHLHHNPWNCGCDSLWLARWLREYIPTNSTCCGRCHSPAHMRGRQL-------- 339
            ..:..|.:|.||||....:....||       |.::..           .|::...|
  Fly   306 VAFLNLFHLRELHLSRLDFLQRIDS-------RAFVDN-----------THLQTLHLNNNPQLSD 352

Zfish   340 --VELDRGDTGAMQC-----------SAPFIADAPRDLNISAERVAELKCRTAAMSAVRWLLPNG 391
              :.|.:|:...::.           ||.|..|..:.|.:...   .|:|..:.:    ||.
  Fly   353 IPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDN---PLQCNCSLL----WLW--- 407

Zfish   392 TILTHASSHPRLTVLNDGTLNFSNVLAGDTGMYTCMVSNAAGNSNASAYLNVSAAELNTSNLSYF 456
                      ||.     |.||..|   |.||     .:|||.:.|:.     |.|.:...|:
  Fly   408 ----------RLV-----TGNFEGV---DPGM-----EHAAGGAVAAL-----AKEADDEELA-- 442

Zfish   457 TTVTVEVLSPTSEMPKPKTTTTTAGASTTTTASPSVFQPVFISTPTVLLQSTDTPPSRPSVIPGS 521
                       .|.....:|.....|.....|...:...:..:.|:....:|.:......::...
  Fly   443 -----------DEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSAYELATSSSNRNSGILRMD 496

Zfish   522 KVTTGKPPNPASTSLDEVMKTTKII---------------IGCFVAVTLLAAIM-LIVFYKLR-- 568
            :...|     .....|:|....|::               :.|.|...||.|:: :.|.|.||
  Fly   497 RQQIG-----CDIWRDKVRTRRKLLTMSEGEITCPAHIVTVVCAVITCLLVAMIGISVLYYLRFV 556

Zfish   569 KRHQ----QRSTVASARTVEIIPVDEELPPSASAANIADEGQLSL-------------------P 610
            ||.:    :|..:.::::  ||.|.:.:....:...:.....::|                   .
  Fly   557 KRRRKLLHERGPMRTSKS--IINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQ 619

Zfish   611 EIRNHNSIYKA--------DYTHKFDYGYKP---KLEYSTHKPKQDFSIHQPKSDYNTYKP---- 660
            .::.|:..::|        :..|::.....|   |||...:...|..:     ::|...||
  Fly   620 TLQAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLELERYLAAQTIA-----NEYRALKPWELP 679

Zfish   661 ------KADYMYQPTLEYSSQKLTDYSHKSLPDYHVHKKPEQS 697
                  :.:::|:           .:.|...||.|...|.:|:
  Fly   680 VKEADDEPEHLYE-----------RFDHYEYPDTHTMSKLKQA 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lrrc4.1	XP_005164844.1	LRRNT	43..77	CDD:214470	10/35 (29%)
		leucine-rich repeat	54..73	CDD:275380	5/18 (28%)
		leucine-rich repeat	75..98	CDD:275380	7/45 (16%)
		LRR_8	76..133	CDD:290566	21/79 (27%)
		LRR_RI	93..323	CDD:238064	73/253 (29%)
		leucine-rich repeat	99..122	CDD:275380	9/22 (41%)
		LRR_8	121..206	CDD:290566	34/108 (31%)
		leucine-rich repeat	123..146	CDD:275380	8/22 (36%)
		leucine-rich repeat	147..170	CDD:275380	13/46 (28%)
		leucine-rich repeat	171..195	CDD:275380	9/23 (39%)
		leucine-rich repeat	196..218	CDD:275380	3/21 (14%)
		LRR_8	218..277	CDD:290566	16/58 (28%)
		leucine-rich repeat	219..242	CDD:275380	6/22 (27%)
		leucine-rich repeat	243..266	CDD:275380	4/22 (18%)
		leucine-rich repeat	267..288	CDD:275380	8/20 (40%)
		IG_like	361..443	CDD:214653	18/81 (22%)
		Ig	372..443	CDD:299845	17/70 (24%)
		STOP	616..799	CDD:283000	17/103 (17%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	2/21 (10%)
		leucine-rich repeat	98..121	CDD:275380	5/22 (23%)
		LRR_8	120..180	CDD:404697	25/59 (42%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	57/234 (24%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	4/22 (18%)
		leucine-rich repeat	218..265	CDD:275380	18/70 (26%)
		leucine-rich repeat	266..289	CDD:275380	4/22 (18%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	8/41 (20%)
		LRR_8	337..397	CDD:404697	9/62 (15%)
		leucine-rich repeat	339..360	CDD:275380	2/20 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910