Protein Alignment tfe3b and Mitf

DIOPT Version :9

• Sequence 1: NP_001038531.1
• Gene: tfe3b / 564996
• ZFINID: ZDB-GENE-010919-3
• Length: 451
• Species: Danio rerio
• Sequence 2: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 615
• Identity: 167/615 - (27%)
• Similarity: 227/615 - (36%)
• Gaps: 253/615 - (41%)

Zfish     2 SSRVLLRQQLMREQAQEQERREAQQQASVAQLRP-------------------ADTTPAI---SV 44
            :||..|:.||.|||   |::...|||.....:.|                   :.:|.|.   |.
  Fly   177 TSRTQLKLQLQREQ---QQQMMIQQQTLDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACGSGSS 238

Zfish    45 SLPPM---------------AARPPPAQ-----VPVEVLKVQTHLENPTKYHIQQAQRQQVKEYL 89
            ||..|               |....|.|     ||.:||:|.|.|||||:||:.|.|:.||::||
  Fly   239 SLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYL 303

Zfish    90 STTL---------------GNKVATQTL------------------------------------- 102
            |.:.               .|..:|..|
  Fly   304 SESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAM 368

Zfish   103 -------------GVSPV--------PHSASAPE-------MGPS-------------------- 119
                         .::|:        .|.|..||       :|.|
  Fly   369 PISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIR 433

Zfish   120 ---------ASSAPNSPMAHLNLGSNKEEMDDVIDDIISLESSFNDDILSLIDSGLQLPNTLPGN 175
                     ::|||.||... ::.::..|.||:.|||:. ..|||.|  ...:|.|.:... |.|
  Fly   434 ISSTSSSLQSTSAPISPSVS-SVATSVSEPDDIFDDILQ-NDSFNFD--KNFNSELSIKQE-PQN 493

Zfish   176 LLDVYNSPGMTTPTITVSNSCPADLPNIKREYTGNVIVIETEARAFMKERQKKDNHNLIERRRRF 240
            |.|                                     .|..|..|:||||||||:|||||||
  Fly   494 LTD-------------------------------------AEMNALAKDRQKKDNHNMIERRRRF 521

Zfish   241 NINDRIKELGALIPKSTDP------EMRWNKGTILKASVDYIRKLQKEQQRAKEIEMRQKKLEQS 299
            ||||||||||.|:||.:|.      ::|.|||||||:|||||:.|:.|..|.::.|:||:::|..
  Fly   522 NINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQ 586

Zfish   300 NQALILRIQELEIQARHHG----------LNATVSP-----GLNTEASFIQNQLLQPNASMQAGV 349
            |:.|:.||:|||:||:.||          |:|...|     .|:..||..:..|.......:..|
  Fly   587 NRKLMSRIKELEMQAKSHGILLSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQV 651

Zfish   350 GDGQPQSHLNMDGAMAQTSPSPFL---------------------SVPPSGSPAAVAVSGPLHLE 393
            .||       .||.|.......|:                     |.|.|.|...:. ||  ..|
  Fly   652 IDG-------ADGNMGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLN-SG--SFE 706

Zfish   394 TFSFTELDEHASDLYPDVGLSDILMDDVRG 423
            ..:|:|.||   .|:.  |.|.:..||..|
  Fly   707 PKNFSEADE---SLFR--GKSSLASDDCCG 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tfe3b	NP_001038531.1	MITF_TFEB_C_3_N	4..144	CDD:292573	59/290 (20%)
		HLH	224..284	CDD:238036	44/65 (68%)
		DUF3371	312..450	CDD:288684	35/148 (24%)
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	20/38 (53%)
		HLH	505..570	CDD:238036	43/64 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593391
Domainoid	1	1.000	85	1.000	Domainoid score	I8110
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4340
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		otm24979
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.860