DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTPS2 and CTPsyn

DIOPT Version :9

Sequence 1:	XP_011543847.1	Gene:	CTPS2 / 56474	HGNCID:	2520	Length:	628	Species:	Homo sapiens
Sequence 2:	NP_001287067.1	Gene:	CTPsyn / 39645	FlyBaseID:	FBgn0266452	Length:	627	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	377/574 - (65%)
Similarity:	455/574 - (79%)	Gaps:	3/574 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    43 MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFVLNDGG 107
            |||||||||||||:|||:||||.||:||||||.||:||||||||||||||||||||||:||:||.
  Fly     1 MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGA 65

Human   108 EVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDAVQEWVMNQAK 172
            ||||||||||||||:.|::||||||||||:.||.|||.|:|||||||||||||||:||||...|:
  Fly    66 EVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQ 130

Human   173 VPVDGNKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHVSLVPQLSATGEQKTK 237
            .||.|: .:||:|::|||||||||||||||||||||||:.||||||..||||||...||||.|||
  Fly   131 TPVQGS-SKPQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTK 194

Human   238 PTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQVICIHDVSSTYRVPVLLEEQ 302
            |||:|||.|||.|||||||||||..||.:.||||||.||||.|:|||||||::|.|.||:|:|:.
  Fly   195 PTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQN 259

Human   303 SIVKYFKERLHLPIGDS-ASNLLFKWRNMADRYERLQKICSIALVGKYTKLRDCYASVFKALEHS 366
            .:::|..|||.|.|..| .:..|.:||::|.|.|.:::...||:||||||..|.||||.|||:|:
  Fly   260 GVIEYLNERLQLNIDMSKRTKCLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVVKALQHA 324

Human   367 ALAINHKLNLMYIDSIDLEKITETEDPVKFHEAWQKLCKADGILVPGGFGIRGTLGKLQAISWAR 431
            |||:|.||.|::|:|..||:.|...:|.|:|:.|||||.:.|||||||||.||..||::|..|||
  Fly   325 ALAVNRKLELVFIESCLLEEETLHSEPSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWAR 389

Human   432 TKKIPFLGVCLGMQLAVIEFARNCLNLKDADSTEFRPNAPVPLVIDMPEHNPGNLGGTMRLGIRR 496
            ..:.|.||:|||:|.||||||||.|.||||::||..||....||||||||:.|.||||||||.|.
  Fly   390 ENQKPLLGICLGLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRLGKRI 454

Human   497 TVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDGDRMEIIELANHPY 561
            |||....|::|:|||:...::||||||:||||..:...|:..:.|||.|||..|||||||:.|||
  Fly   455 TVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFVGTDVDKTRMEIIELSGHPY 519

Human   562 FVGVQFHPEFSSRPMKPSPPYLGLLLAATGNLNAYLQQGCKLSSSDRYSDASDD 615
            ||..|:|||:.|||:|||||:|||:||:...||.|:|:||:||.. :.||||.|
  Fly   520 FVATQYHPEYLSRPLKPSPPFLGLILASVDRLNQYIQRGCRLSPR-QLSDASSD 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTPS2	XP_011543847.1	PLN02327	43..599	CDD:215186	367/556 (66%)
		CTP_synth_N	44..314	CDD:283956	204/269 (76%)
		GATase1_CTP_Synthase	341..586	CDD:153217	147/244 (60%)
CTPsyn	NP_001287067.1	PLN02327	1..556	CDD:215186	367/555 (66%)
		CTP_synth_N	2..271	CDD:283956	204/269 (76%)
		GATase1_CTP_Synthase	299..544	CDD:153217	147/244 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149479
Domainoid	1	1.000	429	1.000	Domainoid score	I597
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I490
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60688
OrthoDB	1	1.010	-	-		D161130at33208
OrthoFinder	1	1.000	-	-		FOG0001109
OrthoInspector	1	1.000	-	-		otm41268
orthoMCL	1	0.900	-	-		OOG6_100470
Panther	1	1.100	-	-	O	PTHR11550
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1048
SonicParanoid	1	1.000	-	-		X676
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940