DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkp3 and p120ctn

DIOPT Version :9

Sequence 1:	NP_001156396.1	Gene:	Pkp3 / 56460	MGIID:	1891830	Length:	822	Species:	Mus musculus
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	194/745 - (26%)
Similarity:	332/745 - (44%)	Gaps:	172/745 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse   168 FGAVGYGG-----TQPT--------------------------PPMPTRP----VSFHERGGAAS 197
            |.|.||..     |:||                          |.:...|    |.:.:.|....
  Fly    46 FSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETNSTDNSIPDIENHPLATTVRYVQAGQYED 110

Mouse   198 RADYDTLSLRSLRLGPGGLDDRYSVVSEQLEPAAASTYRAYAYERQAS--------------SGS 248
            .::|....|..      |:|..|:  :|.:.|        |.|...|:              ||.
  Fly   111 TSEYGVAGLTC------GIDSEYT--AEAVVP--------YCYTSDANYTGIQNTTSSIKPFSGR 159

Mouse   249 SRAGGLDWPEATEGPPSRTIRAPAMRTLQRFQSSHRSRGGTGSVSGAGLEPVARAPSVRSLSLSL 313
            .....::..||......||.::.|...|.:|..|                      |:.::...|
  Fly   160 PFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMS----------------------SINTVPQRL 202

Mouse   314 ADSGHLPDVRGLDSYTGHRTLQRLSSGFDDI---------DLPSAVKYLMASDPNLQVLGAAYIQ 369
            .:.         |.|        :....:||         :|...:.:|......::...|||:|
  Fly   203 EEK---------DDY--------IEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQ 250

Mouse   370 HRCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRHATGAMRNLIY--DNVDNKLALVEENGIFE 432
            |.||.|...|::.|||..:|.||:|.::.:.|:.::|.||:|||.|  .|.:||..:....||..
  Fly   251 HLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAA 315

Mouse   433 LLRTL-REQDDELRKNVTGILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSG-----AGGPPLIQ 491
            |:..| |.|:.|:::.|||:|||:||.:.||..:..:.|..:...|:.|.||     .|
  Fly   316 LVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCG------ 374

Mouse   492 QNASEAEIFYNATGFLRNLSSASQATRQKMRECHGLVDALVTYINHALDVGKCEDKSVENAVCVL 556
             ....:.:|.||:|.|||:|||.:..|..:|.|..||:.|:..:..:::.....:|:|||.||:|
  Fly   375 -ETCFSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCIL 438

Mouse   557 RNLSYRL-------YDEMPPSALQRLEGRGRRDMAGAPPGEMVGCFTPQSRR--------LRELP 606
            ||||||.       ||:.|....:|:       :..:..||.:|||....::        |.|..
  Fly   439 RNLSYRCQEVDDPNYDKHPFITPERV-------IPSSSKGENLGCFGTNKKKKEANNSDALNEYN 496

Mouse   607 LTAD----ALTFAEVSKDPKGLEWLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRW 667
            ::||    ::|:.:::   ||.|.||.|::|..|..|||.|. |..|.||||||:||::|  ..|
  Fly   497 ISADYSKSSVTYNKLN---KGYEQLWQPEVVQYYLSLLQSCS-NPETLEAAAGAIQNLSA--CYW 555

Mouse   668 AGVLS-RLALEQERILNPLLDRVRTADHNQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLP- 730
            ...:. |..:.:|:.|..|::.:|......:.::...:|||:.:.|||:.:....:..|::|||
  Fly   556 QPSIDIRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPS 620

Mouse   731 GSV-GEKCPPAEVLVNIIAVLNNLVVASPIAARDLLYFDGLRKLVFIKKKRDSPDSEKSS----R 790
            |:| .::....:.:..::|.:|.::..:|..:|.||...|:.:|:.|.|::     ||.:    :
  Fly   621 GNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRK-----EKYTSCVLK 680

Mouse   791 AASSLLANLWQYSKLHRDFRAKGYRKEDFL 820
            .||.:|..:||:::|...::..|::::||:
  Fly   681 FASQVLYTMWQHNELRDVYKKNGWKEQDFV 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkp3	NP_001156396.1	ARM	346..457	CDD:237987	42/113 (37%)
		armadillo repeat	346..371	CDD:293788	6/24 (25%)
		armadillo repeat	379..415	CDD:293788	15/35 (43%)
		armadillo repeat	421..455	CDD:293788	13/34 (38%)
		ARM	422..560	CDD:237987	48/143 (34%)
		armadillo repeat	474..510	CDD:293788	11/40 (28%)
		armadillo repeat	518..559	CDD:293788	14/40 (35%)
		armadillo repeat	673..707	CDD:293788	6/33 (18%)
		ARM	674..801	CDD:237987	31/132 (23%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	42/113 (37%)
		armadillo repeat	227..252	CDD:293788	6/24 (25%)
		armadillo repeat	260..296	CDD:293788	15/35 (43%)
		armadillo repeat	304..339	CDD:293788	13/34 (38%)
		ARM	307..442	CDD:237987	48/141 (34%)
		armadillo repeat	347..392	CDD:293788	12/51 (24%)
		armadillo repeat	515..556	CDD:293788	21/43 (49%)
		ARM	516..643	CDD:237987	40/129 (31%)
		armadillo repeat	562..596	CDD:293788	6/33 (18%)
		armadillo repeat	601..641	CDD:293788	10/39 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.810