Protein Alignment Foxo1 and fd96Cb

DIOPT Version :10

• Sequence 1: NP_062713.2
• Gene: Foxo1 / 56458
• MGIID: 1890077
• Length: 652
• Species: Mus musculus
• Sequence 2: NP_524496.1
• Gene: fd96Cb / 43011
• FlyBaseID: FBgn0004898
• Length: 271
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 74/305 - (24%)
• Similarity: 110/305 - (36%)
• Gaps: 71/305 - (23%)

Mouse   146 PRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSI 210
            ||....|..:.....||..|...||..|.::.|.||:||.:::...|:::     .::..|:||:
  Fly     2 PRPLKMSYGDQKPPYSYISLTAMAIIHSPQRLLPLSEIYRFIMDQFPFYR-----KNTQKWQNSL 61

Mouse   211 RHNLSLHSKFIRVQNEGT--GKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKAS 273
            |||||.:..||:|....|  ||.|:|.|:|           .|..|..|....:.|.|...|:..
  Fly    62 RHNLSFNDCFIKVPRNVTKAGKGSYWTLHP-----------MAFDMFENGSLLRRRKRFRVKQLE 115

Mouse   274 LQSGQEGPGDSPGSQFSKWPASPG------SHSNDDFDNWSTF-----RPRTSSNASTISGRLSP 327
                         ...|.|..:..      :|..||......|     .....:|||  :.::||
  Fly   116 -------------KDISNWKLAAAANTEMVTHYLDDQLTQMAFADPARHGHVLANAS--AAQMSP 165

Mouse   328 IMTEQDDLGDGDVHSLVYPPSAAKMASTLPSL---------------SEISNPENME------NL 371
            .......|..    ::...|:..|.|.|:.||               .|..:|:.:.      ||
  Fly   166 YKATPPILPT----TVTQLPARPKRAFTIESLMAPDPASTPNEGLVPMEYGSPDAVALEKPPFNL 226

Mouse   372 LDNLNLLSSPTSLTVSTQSSPGSMMQQTPCYSFAPPNTSLNSPSP 416
            ..|.|.|::...|...:....| .....|||...|| ...|.|.|
  Fly   227 PFNFNELAAQYQLYFPSFFYNG-QYGNIPCYQKTPP-LFHNGPLP 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Foxo1	NP_062713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..154		3/7 (43%)
		FH_FOXO1	148..246	CDD:410834	31/99 (31%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	208..215		5/6 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..342		22/121 (18%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	231..234		1/2 (50%)
		Nuclear localization signal. /evidence=ECO:0000250	248..250		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393	280..562		35/169 (21%)
		Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200	360..456		17/63 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410		7/26 (27%)
		FOXO_KIX_bdg	420..501	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471	459..463
		FOXO-TAD	594..630	CDD:435506
fd96Cb	NP_524496.1	FH_FOX	1..110	CDD:469596	38/123 (31%)