Protein Alignment Foxo1 and FoxP

DIOPT Version :10

• Sequence 1: NP_062713.2
• Gene: Foxo1 / 56458
• MGIID: 1890077
• Length: 652
• Species: Mus musculus
• Sequence 2: NP_001247011.1
• Gene: FoxP / 41182
• FlyBaseID: FBgn0262477
• Length: 520
• Species: Drosophila melanogaster
• Alignment Length: 244
• Identity: 69/244 - (28%)
• Similarity: 105/244 - (43%)
• Gaps: 80/244 - (32%)

Mouse   161 SYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQN 225
            :||.||.:||..|.:|:|||::||.|...:..||:     .::|.|||:||.|||||..|:|.::
  Fly   332 TYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCYFR-----RNAATWKNAIRTNLSLHKCFVRYED 391

Mouse   226 EGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAK----SRGRAAKKKA-----SLQSGQEGP 281
            :   ..|:||                  :|:| :|.|    ||||..|.:.     |.|||...|
  Fly   392 D---FGSFWM------------------VDDN-EFVKRRHLSRGRPRKYEPSSSPNSCQSGNGVP 434

Mouse   282 GD-SPGSQFSKWPAS--PGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGDGDVHSL 343
            .| :|....::...|  ||:      ||     |..|:|.:.:                |.:..|
  Fly   435 TDKNPCDNCTQHCTSLPPGA------DN-----PLDSNNPNDL----------------GRIGCL 472

Mouse   344 VYPPSAAKMASTLPSLSEISNP-ENMENLLDNLNLLSSPTSLTVSTQSS 391
            .|..|        ..||:.|.. .||::     .::.|.:.||:...|:
  Fly   473 PYCGS--------DGLSKASKDYSNMDS-----GMIESNSHLTIDEYST 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Foxo1	NP_062713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..154
		FH_FOXO1	148..246	CDD:410834	32/84 (38%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	208..215		4/6 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..342		28/122 (23%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	231..234		1/2 (50%)
		Nuclear localization signal. /evidence=ECO:0000250	248..250		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393	280..562		24/116 (21%)
		Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200	360..456		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410		3/9 (33%)
		FOXO_KIX_bdg	420..501	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471	459..463
		FOXO-TAD	594..630	CDD:435506
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:465036
		FH_FOX	327..408	CDD:469596	36/102 (35%)