Protein Alignment Foxo1 and bin

DIOPT Version :10

• Sequence 1: NP_062713.2
• Gene: Foxo1 / 56458
• MGIID: 1890077
• Length: 652
• Species: Mus musculus
• Sequence 2: NP_523950.2
• Gene: bin / 38766
• FlyBaseID: FBgn0045759
• Length: 676
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 143/617 - (23%)
• Similarity: 211/617 - (34%)
• Gaps: 203/617 - (32%)

Mouse    18 PRQRSCTWPLPRPEFNQSNSTTSSPAPSGGAAANPDAAASLASASAVSTDFMSNLSLLEESEDFA 82
            |:|      ||..:...|        |.||                    :||.:| ...|:..:
  Fly   211 PQQ------LPAQQLQHS--------PGGG--------------------YMSRIS-TSPSQVIS 240

Mouse    83 RAPGCVAVAAAAAASRGLCGDFQGPEAGCVHPAPPQPPPTGPLSQPPPVPPSAAAAAG------- 140
            .|.| :.|...:::|........|.|:        .||....|..  .|..||....|
  Fly   241 NAHG-MPVLNYSSSSSSPAKSLNGSES--------SPPSQNHLEN--KVSGSAVVGTGGSSQQDA 294

Mouse   141 PLAGQPRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAG 205
            |......|.|.:||.....|||.::|..||:.|...:||||:||.::.||..:|:     ....|
  Fly   295 PSTPDTTKKSGTRRPEKPALSYINMIGHAIKESPTGKLTLSEIYAYLQKSYEFFR-----GPYVG 354

Mouse   206 WKNSIRHNLSLHSKFIRV-QNEGT---GKSSWWMLNPEGGKSGKSPRRRAASM--DNNSKFAKSR 264
            ||||:||||||:..|.:: :..|.   ||.::|.::           ..:|.:  |..|...:.|
  Fly   355 WKNSVRHNLSLNECFKKLPKGMGVGKPGKGNYWTID-----------ENSAHLFEDEGSLRRRPR 408

Mouse   265 GRAAKKKASLQSGQ------EGPGDSPGSQFSKWPASPGSHSND---------------DF-DNW 307
            |..:|.|....:|.      .|.||: |.....:.|||...|.|               .| |.|
  Fly   409 GYRSKIKVKPYAGHANGYYASGYGDA-GMDNGNYYASPAFASYDYSAAGATGVSPAGGQGFADPW 472

Mouse   308 STFRPRTSSNASTISGRLSPI--MTEQDDL-GDGDVH-SLVYPPSAAKMASTLPSLSEISNPENM 368
            :.....:.|::..:...:.|:  .|....| ..|:|: |...||.|.......||.|..|:|
  Fly   473 NAHAAHSGSSSVGVGMGVGPLPQYTNISCLAAGGNVNGSATTPPLAHSALGMAPSASSSSSP--- 534

Mouse   369 ENLLDNLNLLSSPTSLTVSTQSSPGSMMQQTPCYSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQ 433
               |.....|.|..:.|.|..::.         ||:|....||::          |..|:|
  Fly   535 ---LGAAATLQSDYAPTASLVAAG---------YSYATSAGSLDN----------GLRSIS---- 573

Mouse   434 MPMQTLQDSKSSYGGLNQYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVMMGPN 498
              :|.|                |||                |.:....||..::....:
  Fly   574 --LQQL----------------PGL----------------SSIQHAQAQAQAQAHHHH------ 598

Mouse   499 SVMPAYGSQASHNKMMNPSSHTHPGHA--QQTASVNGRTLP-------HVVNTMPHTSAMNRLTP 554
                 :...|||      .||:|.||.  .|....:..|.|       |.::..|    ::| .|
  Fly   599 -----HQHHASH------PSHSHQGHGSMHQNHGTSSTTPPPSQSGGSHGIDHSP----IDR-KP 647

Mouse   555 VKTPLQVPLSHPMQMSAL----GSYSSVSSCN 582
            ...|   |:|.|..|.||    |.|..:...|
  Fly   648 AYLP---PISPPPMMVALNGGGGYYEGLKYAN 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Foxo1	NP_062713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..154		10/48 (21%)
		FH_FOXO1	148..246	CDD:410834	36/101 (36%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	208..215		5/6 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..342		27/138 (20%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	231..234		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000250	248..250		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393	280..562		64/310 (21%)
		Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200	360..456		18/95 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410		5/26 (19%)
		FOXO_KIX_bdg	420..501	CDD:465228	11/80 (14%)
		Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471	459..463		0/3 (0%)
		FOXO-TAD	594..630	CDD:435506
bin	NP_523950.2	FH_FOX	312..391	CDD:469596	32/94 (34%)