Protein Alignment Foxo1 and FoxL1

DIOPT Version :10

• Sequence 1: NP_062713.2
• Gene: Foxo1 / 56458
• MGIID: 1890077
• Length: 652
• Species: Mus musculus
• Sequence 2: NP_523912.1
• Gene: FoxL1 / 38471
• FlyBaseID: FBgn0004895
• Length: 365
• Species: Drosophila melanogaster
• Alignment Length: 370
• Identity: 88/370 - (23%)
• Similarity: 139/370 - (37%)
• Gaps: 103/370 - (27%)

Mouse   128 PPPVPPSAAAAAGPLAGQPRKTSSS-------------RRNAWG---------------NLSYAD 164
            |.|:.|||...|| :.|....:.|.             ..|.||               ..||..
  Fly    35 PNPLAPSAVGGAG-MEGLMCGSFSPAFYYQGIDSFLALHNNIWGLPISFLHNSHRPEKPPFSYIA 98

Mouse   165 LITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV------ 223
            ||..||.|:..:|||||.||::::...||:::     :..||:|||||||||:..|:::
  Fly    99 LIAMAISSAPNQRLTLSGIYKFIMDKFPYYRE-----NKQGWQNSIRHNLSLNDCFVKIPRDKNT 158

Mouse   224 --QNEGTGKSSWWMLNPEGG---KSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQE-GPG 282
              .|:..||.|:|||:....   :.|...|||.         .:.|......:...:||:: ..|
  Fly   159 IEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRT---------RRQRHCGHPNRYERESGKDSNDG 214

Mouse   283 DSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGDGDVHSLVYPP 347
            :|..::. :.|:.|.|    |||.:...||..|...:.:..:...:....:.|.:.:...|
  Fly   215 NSSAAEI-RSPSEPLS----DFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGL---- 270

Mouse   348 SAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGSMMQQTPCYSFAPPNTSLN 412
                  ..||.:.|.  |::                  |...||....||     |....:..|:
  Fly   271 ------RPLPEIREC--PDD------------------VDASSSSSKAMQ-----SSMELHEELH 304

Mouse   413 SPSPNYSKYTYGQSSMSPLPQMPMQTLQDSKSSYGGLNQYNCAPG 457
            |||.........::|.|..|.:        ..::.|:.....|||
  Fly   305 SPSAFTPPLNRRETSSSGAPVL--------AEAFNGIKDVVDAPG 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Foxo1	NP_062713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..154		9/38 (24%)
		FH_FOXO1	148..246	CDD:410834	40/136 (29%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	208..215		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..342		23/114 (20%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	231..234		1/2 (50%)
		Nuclear localization signal. /evidence=ECO:0000250	248..250		1/1 (100%)
		Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393	280..562		34/178 (19%)
		Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200	360..456		16/95 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410		6/26 (23%)
		FOXO_KIX_bdg	420..501	CDD:465228	7/38 (18%)
		Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471	459..463
		FOXO-TAD	594..630	CDD:435506
FoxL1	NP_523912.1	FH_FOX	89..186	CDD:469596	36/101 (36%)