Protein Alignment Foxo1 and fd59A

DIOPT Version :10

• Sequence 1: NP_062713.2
• Gene: Foxo1 / 56458
• MGIID: 1890077
• Length: 652
• Species: Mus musculus
• Sequence 2: NP_523814.1
• Gene: fd59A / 37631
• FlyBaseID: FBgn0004896
• Length: 456
• Species: Drosophila melanogaster
• Alignment Length: 257
• Identity: 76/257 - (29%)
• Similarity: 100/257 - (38%)
• Gaps: 81/257 - (31%)

Mouse    65 STDFMSNL--------SLLEES---EDFARAPGCVA---VAAAAAASRGLCGDFQGPEAGCVHPA 115
            |||.|..|        .|::.|   .......||.|   .|||.|.|.| |.|
  Fly     4 STDPMHTLHDSVSLSPPLIKSSRGGSSIGNGIGCSASSRTAAADAMSMG-CDD------------ 55

Mouse   116 PPQPPPTGPLSQPPPVPPSAAAAAGPLAGQPRKTSSSRRNAWGNL-----SYADLITKAIESSAE 175
                         ..:.||:...:|...|....:.||    .|.|     ||..|||.||..|..
  Fly    56 -------------SDIEPSSMGGSGAAGGNGDGSGSS----GGPLVKPPYSYIALITMAILQSPH 103

Mouse   176 KRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNE--GTGKSSWWMLNP 238
            |:||||.|.::::...||:|||     ...|:|||||||||:..||:|..|  ..||.::|.|:|
  Fly   104 KKLTLSGICDFIMSRFPYYKDK-----FPAWQNSIRHNLSLNDCFIKVPREPGNPGKGNFWTLDP 163

Mouse   239 EGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQEGPGDSPGSQFSKWPASPGSHS 300
                       .|..|.:|..|.:.|.|..:              :|..|...:||..|:.|
  Fly   164 -----------LAEDMFDNGSFLRRRKRYKR--------------APTMQRFSFPAVFGTLS 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Foxo1	NP_062713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..154		6/41 (15%)
		FH_FOXO1	148..246	CDD:410834	42/104 (40%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	208..215		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..342		15/70 (21%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	231..234		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000250	248..250		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393	280..562		6/21 (29%)
		Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200	360..456
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410
		FOXO_KIX_bdg	420..501	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471	459..463
		FOXO-TAD	594..630	CDD:435506
fd59A	NP_523814.1	FH_FOXD4-like	85..180	CDD:410822	43/110 (39%)