DRSC/TRiP Functional Genomics Resources

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Protein Alignment Foxo1 and slp2

DIOPT Version :10

Sequence 1:NP_062713.2 Gene:Foxo1 / 56458 MGIID:1890077 Length:652 Species:Mus musculus
Sequence 2:NP_476834.1 Gene:slp2 / 33608 FlyBaseID:FBgn0004567 Length:451 Species:Drosophila melanogaster


Alignment Length:364 Identity:98/364 - (26%)
Similarity:136/364 - (37%) Gaps:122/364 - (33%)


- Green bases have known domain annotations that are detailed below.


Mouse   144 GQPRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKN 208
            |:|.|  ..:.|.....||..||..||..|:||||||:.|||:::.:.||::|     :..||:|
  Fly   169 GKPVK--DKKGNEKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRD-----NKQGWQN 226

Mouse   209 SIRHNLSLHSKFIRVQN--EGTGKSSWWMLNPE------GGKSGKSPRRRAASMDNNSKFAKSRG 265
            ||||||||:..|::|..  :..||.::|||:|.      ||.:||..||..|:         ||.
  Fly   227 SIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTTAA---------SRS 282

Mouse   266 RAAKKKASLQSGQEGPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMT 330
            |.|..|.||..                |..||..:...|..:.|:.|...|..:::..|.:|...
  Fly   283 RLAAFKRSLIG----------------PMFPGLAAYPQFGQFLTYPPTAPSLLASMYQRYNPFAP 331

Mouse   331 EQDDLGDGDVHSLVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGSM 395
            :     .|..|..: ||.       ||.|.....|                       |..||  
  Fly   332 K-----GGPGHPGL-PPG-------LPGLPGPPGP-----------------------QGPPG-- 358

Mouse   396 MQQTPCYSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQMPMQTLQDSKSSYGGLNQYNCAPGLL- 459
               .|...|..|.||    |..|.:..|.|.                      |:|:..|..|. 
  Fly   359 ---PPPPPFVAPPTS----SELYQRLQYQQL----------------------LHQHAAAAALAA 394

Mouse   460 --KEL------LTSDSPP---HNDI---MSPVDPGVAQP 484
              ::|      ..|..||   |..:   .:|:.||...|
  Fly   395 HQRQLSVAAASAASQPPPTHHHPHLAVGQAPLSPGGDSP 433

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Foxo1NP_062713.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..154 3/9 (33%)
FH_FOXO1 148..246 CDD:410834 43/105 (41%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 208..215 6/6 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..342 28/116 (24%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778 231..234 0/2 (0%)
Nuclear localization signal. /evidence=ECO:0000250 248..250 1/1 (100%)
Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393 280..562 42/220 (19%)
Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200 360..456 15/95 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..410 6/26 (23%)
FOXO_KIX_bdg 420..501 CDD:465228 15/80 (19%)
Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471 459..463 1/12 (8%)
FOXO-TAD 594..630 CDD:435506
slp2NP_476834.1 FH_FOXG 180..258 CDD:410795 37/82 (45%)
Blue background indicates that the domain is not in the aligned region.

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