Protein Alignment Foxo1 and fd19B

DIOPT Version :10

• Sequence 1: NP_062713.2
• Gene: Foxo1 / 56458
• MGIID: 1890077
• Length: 652
• Species: Mus musculus
• Sequence 2: NP_608369.1
• Gene: fd19B / 33010
• FlyBaseID: FBgn0031086
• Length: 260
• Species: Drosophila melanogaster
• Alignment Length: 159
• Identity: 46/159 - (28%)
• Similarity: 75/159 - (47%)
• Gaps: 30/159 - (18%)

Mouse   151 SSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLS 215
            :::.||....:|:.||..||.||:|||||||.|.:|:..:.||::.:     .:.|:||||||||
  Fly    52 AAKSNAKPAFTYSALIVMAIWSSSEKRLTLSGICKWIADNFPYYRTR-----KSVWQNSIRHNLS 111

Mouse   216 LHSKFIRVQN--EGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQ 278
            |:..|:||..  :..|:..:|.|:|..               .:....::.||..:     .:.|
  Fly   112 LNPFFVRVPRALDDPGRGHYWALDPYA---------------EDLSIGETTGRLRR-----SNWQ 156

Mouse   279 EGPGDSP---GSQFSKWPASPGSHSNDDF 304
            :..|..|   |..:.:.|.....|.|..:
  Fly   157 QNTGARPKVTGHPYQRMPYYGHGHGNGPY 185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Foxo1	NP_062713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..154		0/2 (0%)
		FH_FOXO1	148..246	CDD:410834	37/96 (39%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	208..215		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..342		12/77 (16%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:Q12778	231..234		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000250	248..250		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000269|PubMed:20061393	280..562		6/28 (21%)
		Required for interaction with RUNX2. /evidence=ECO:0000269|PubMed:21471200	360..456
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..410
		FOXO_KIX_bdg	420..501	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000269|PubMed:15220471	459..463
		FOXO-TAD	594..630	CDD:435506
fd19B	NP_608369.1	Forkhead	58..140	CDD:459732	35/101 (35%)