DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cacna1e and para

DIOPT Version :9

Sequence 1:XP_017212914.2 Gene:cacna1e / 564274 -ID:- Length:2444 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2310 Identity:522/2310 - (22%)
Similarity:895/2310 - (38%) Gaps:728/2310 - (31%)


- Green bases have known domain annotations that are detailed below.


Zfish   133 IEQRDIIKAHQAHKIQSTPQARRKEWEMARFGDDVPGLLGAGDGGSERSRNRDAPAVSTGGVSPA 197
            ||||  |.|.  |:.|...:.:|.|.|:.::|..........|...|....:..|.:..|...|.
  Fly    27 IEQR--IAAE--HEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQGVPIPV 87

Zfish   198 FKQTK--AQRARTMALYNPIPVRQNC--------------FTVNRSLFIFGEDNIVRKYAKKIIE 246
            ..|..  .:.|.| .|.:..|...|.              |:.::::::....|.:|:.|..|:.
  Fly    88 RLQGSFPPELAST-PLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILV 151

Zfish   247 WPPFEYMILATIIANCIVLALEQHLPGEDKTPMAKRLEKTEPYFIGMFCFEAGIKIIALGFVFHK 311
            .|.|...|:.||:.|||::.:          |....:|.||..|.|::.||:.:|::|.||:...
  Fly   152 HPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILCP 206

Zfish   312 GSYLRNGWNVMDFIVVSSGILATAGAHMNISL-DLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMK 375
            .:|||:.||.:||:|:     |.|...|.|.| :|..||..||||.||.|:.:|.|:.::.::::
  Fly   207 FTYLRDAWNWLDFVVI-----ALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIE 266

Zfish   376 AMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHKQCEPVGK---------------DSERADS--- 422
            ::..|..:.:|..|::.:||::||:.|.|.|.::|  :.|               |....:|   
  Fly   267 SVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC--IKKFPLDGSWGNLTDENWDYHNRNSSNW 329

Zfish   423 -PENE---FP-C----GSKLCPDHYNC-SGYWTGPNDGITQFDNILFSLLTVFQCITMEGWTTIL 477
             .|:|   || |    |:..|.|.|.| .|:...||.|.|.||:..::.|:.|:.:|.:.|..:.
  Fly   330 YSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLY 394

Zfish   478 YYTNDALGSTWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMK--LRRQQQ--- 537
            .....|.| .|:.|:||.:|.:|||:::||:|.:::..:.:.:::.|...|..:  :|..::   
  Fly   395 QLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAA 458

Zfish   538 -----IERELNGY-RAWID--RAEEVMLAEE-------------------------NKNS----- 564
                 :|...|.. :|..|  .|||..|..|                         ||..     
  Fly   459 AKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRS 523

Zfish   565 ---GPSALDVLKR---------ATTIK---------------------------------RRGVD 584
               ...::.|::|         ||.::                                 |.|:.
  Fly   524 VEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIP 588

Zfish   585 DARRAP--------EEQ---YADISSLGMPLNR-----------ASIRSAKRGPTSYFRR----- 622
            .:.|.|        .:|   |||.|:...|::.           .::.|.....||:..|     
  Fly   589 GSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTS 653

Zfish   623 -----------------KERLLRISVRR------------------------------------- 633
                             ||..||....|                                     
  Fly   654 HGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGK 718

Zfish   634 ----------MVKTQT-------------------------------FY---------------- 641
                      .|:|||                               :|                
  Fly   719 IKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDK 783

Zfish   642 --------------------------WTVLGL------------VALNTLCVAIVHHKQPQWLSS 668
                                      |..|.:            :.:||:.:|:.||...:.:..
  Fly   784 ALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMER 848

Zfish   669 LLYYAEFLFLGLFLTEMFLKMYGLGPRLYFHSSFNCFDCGVIVGSIFEVFWGFFRPGTSFGISVL 733
            :|....:.|...|..|..:|:..:.|:.||...:|.||..::..|:.|:  |.  .|.. |:|||
  Fly   849 VLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLEL--GL--EGVQ-GLSVL 908

Zfish   734 RALRLLRIFKITKYWASLRNLVVSLM-NSMKSIISLLFLLFLFIVVFALLGMQLFG-------GR 790
            |:.||||:||:.|.|.:| ||::|:| .:|.::.:|.|:|.:.|.:||::||||||       .|
  Fly   909 RSFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDR 972

Zfish   791 FIFDEYTPTNFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVKSGMWSSVY---------FIV 846
            |...:....||..|..:.|.||::|.|| |.|              .||..:|         |:.
  Fly   973 FPDGDLPRWNFTDFMHSFMIVFRVLCGE-WIE--------------SMWDCMYVGDVSCIPFFLA 1022

Zfish   847 LTLFGNYTLLNVFLAIAVDNLA----NAQELTKDEEEEEEAFNQKHALQKAKEVGPMSSFMSSER 907
            ..:.||..:||:|||:.:.|..    :|.....|..:..||||:         :|...|::    
  Fly  1023 TVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNR---------IGRFKSWV---- 1074

Zfish   908 RRRPYLYRKRAIH------RSRAAYSFEDAESLADARPFNASNSFMSRRERRRRLTMSVWEQRTS 966
                    ||.|.      |::......|..|                .||..:::. :|.:...
  Fly  1075 --------KRNIADCFKLIRNKLTNQISDQPS----------------GERTNQISW-IWSEGKG 1114

Zfish   967 QLR--------RHRQMSSREILFSSPSEEQDGPPGCPLHRKPGLSPSGSKRRATETTSTTIMPEG 1023
            ..|        ...::...|||                  ..||...|.|.:.....:.....|.
  Fly  1115 VCRCISAEHGDNELELGHDEIL------------------ADGLIKKGIKEQTQLEVAIGDGMEF 1161

Zfish  1024 TLEPPMPMDMPVDEQALPISIPEPPLAIPIPEPPMPVDACLPEPPVTLNLPLTEPSESKTSPEGA 1088
            |:...|..:.|...:.|                                        :..:.:..
  Fly  1162 TIHGDMKNNKPKKSKYL----------------------------------------NNATDDDT 1186

Zfish  1089 LDINNHCPRLNGNRRQRAVRKHRPPAMGDMLTPDMGPRPRRPRHRELHTDPRGK-ETLQGDGVDG 1152
            ..||::                             |....||...|.|   :|. ||:       
  Fly  1187 ASINSY-----------------------------GSHKNRPFKDESH---KGSAETM------- 1212

Zfish  1153 KEQKPGSEGDEKSDGEISPDGRGLEQRQNKPDNTESSTESKPANSPRKIPPLDSEPATLQLTDNT 1217
                   ||:||.|.  |.:..||::.                        ||.|          
  Fly  1213 -------EGEEKRDA--SKEDLGLDEE------------------------LDEE---------- 1234

Zfish  1218 LQQSSQGTTCAGETDNNNHGSLNQDKSSLNTSIVIEVTDTQPSMELTSITGNSKDVEASKPEKEE 1282
                       ||.:   .|.|:.|       |:|...|                        |:
  Fly  1235 -----------GECE---EGPLDGD-------IIIHAHD------------------------ED 1254

Zfish  1283 ETPDAPKGPPPVSMFIFKP------NNP-------VRRACHYVVNLRYFEMSILLVIAASSIALA 1334
            ...:.|....|.|.:...|      ::|       :|.....::..:|||.:::.:|..||:|||
  Fly  1255 ILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALA 1319

Zfish  1335 AED------PVNTNSDRNKVLRYFDYVFTGVFTFEMIIKMIDQGLVLHYGSYFRDPWNILDFIVV 1393
            .||      |:     ...:|.|.|.:||.:|..||:||.    |.|.:..||.:.|..|||::|
  Fly  1320 LEDVHLPQRPI-----LQDILYYMDRIFTVIFFLEMLIKW----LALGFKVYFTNAWCWLDFVIV 1375

Zfish  1394 VGALVAFALTNVMGSNTGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIV 1458
            :.:|:.| :.:::|:.   .|:..|::|.||.||||:.:.|:..::.|.:.:|.::.::||:|:|
  Fly  1376 MVSLINF-VASLVGAG---GIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLV 1436

Zfish  1459 YKLFMFIFAVIAVQLFKGKFYYCTDSSK--------DTENECKGYYIDYDKDKKKEKREWKRRDF 1515
            ..:|..|||::.||||.||::.|.|.:.        ...|.|           :.|...|.....
  Fly  1437 CLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNAC-----------ESENYTWVNSAM 1490

Zfish  1516 HYDNVVWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSQGNRMEMSIFYVIYFVVFPFFFVNIF 1580
            ::|:|..|.|.||.|:|.:||.|::..::|..|.|:.|.:...:.|.:::|.:.:...||.:|:|
  Fly  1491 NFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLF 1555

Zfish  1581 VALIIITFQEQGDK--------MMEECSLEKNERACIDFAISAKPLTRYMPQNRQTLQYRLWQFV 1637
            :.:||..|.||..|        |.|:   :|.....:....|.||| :.:|:.|...|..:::.|
  Fly  1556 IGVIIDNFNEQKKKAGGSLEMFMTED---QKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVFEIV 1616

Zfish  1638 VSPSFEYTVLTMIALNTIVLMMKHHDPRLEGYDDVLKYLNTIFTVIFSVECVLKILAFGIMNYFR 1702
            ....|:..::..|.||...:.:..:|.. :.|:.||.|||.||.||||.||:|||.|.. .:||.
  Fly  1617 TDKKFDIIIMLFIGLNMFTMTLDRYDAS-DTYNAVLDYLNAIFVVIFSSECLLKIFALR-YHYFI 1679

Zfish  1703 DTWNIFD----FITVLGSITEILVDKFQTGKTFNMGFLKLFRAARLIKLLRQGYTIRILLWTFVQ 1763
            :.||:||    .:::||.:...:::|:....|. :..:::.:..|:::|::....||.||:....
  Fly  1680 EPWNLFDVVVVILSILGLVLSDIIEKYFVSPTL-LRVVRVAKVGRVLRLVKGAKGIRTLLFALAM 1743

Zfish  1764 SFKALPYVCLLIAMLFFIYAIIGMQVFGNIKINEKTQINEHNNFRTFFGALMLLFRSATGESWQE 1828
            |..||..:|||:.::.||:||.||..|.::|  ||:.||:..||:||..:::|||:.:|...|..
  Fly  1744 SLPALFNICLLLFLVMFIFAIFGMSFFMHVK--EKSGINDVYNFKTFGQSMILLFQMSTSAGWDG 1806

Zfish  1829 IMLSCLGEKECEIDTSVNSTTKTIKNDCGT-DFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLT 1892
            ::.:.:.|:.|  |...|.  |....:||: .....:.:|::..|..:::|:::|||::|:...|
  Fly  1807 VLDAIINEEAC--DPPDND--KGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQAT 1867

Zfish  1893 RD-SSILGPHHLDEFVRIWGEYDRAACGKLHYKEMYKVVRTISPPLGFGKNCPYRVACKRLVLMN 1956
            .| ...|.....|.:..||.::|......:.|.::.:.:..:.|||...|...|::     :.|:
  Fly  1868 EDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKI-----ISMD 1927

Zfish  1957 MPVDEDMSVHFTSTLMALIRTALDIKIARG---------GEDRGQMDVELQKEI-SVIWPHLSQK 2011
            :|:.....::....|.||.:   |....:|         ||...:.|.|..:.: |.:|....: 
  Fly  1928 IPICRGDLMYCVDILDALTK---DFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREE- 1988

Zfish  2012 SLDLLVPIHKASDMTIGKIYAAMMIMDYYKQNKAK 2046
                               |.|.:|...::::||:
  Fly  1989 -------------------YCARLIQHAWRKHKAR 2004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1eXP_017212914.2 Ion_trans 247..524 CDD:306908 93/305 (30%)
Ion_trans 640..875 CDD:306908 80/309 (26%)
Atrophin-1 887..>1210 CDD:331285 45/337 (13%)
Ion_trans 1316..1549 CDD:306908 78/246 (32%)
Ion_trans 1639..1896 CDD:306908 82/262 (31%)
GPHH 1897..1967 CDD:318993 13/69 (19%)
Ca_chan_IQ 1969..2043 CDD:312334 14/83 (17%)
Transformer 2203..2368 CDD:253769
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 88/288 (31%)
Na_trans_cytopl 515..648 CDD:288761 19/132 (14%)
Ion_trans 835..1028 CDD:278921 66/213 (31%)
Na_trans_assoc 1054..1296 CDD:284034 65/464 (14%)
Ion_trans 1318..1571 CDD:278921 86/276 (31%)
Na_channel_gate 1561..1613 CDD:240441 14/55 (25%)
Ion_trans 1636..1871 CDD:278921 78/243 (32%)
GPHH 1880..1930 CDD:293510 11/54 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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