DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyp11a2 and Cyp12d1-d

DIOPT Version :9

Sequence 1:	XP_021329545.1	Gene:	cyp11a2 / 563363	ZFINID:	ZDB-GENE-130911-1	Length:	512	Species:	Danio rerio
Sequence 2:	NP_995812.1	Gene:	Cyp12d1-d / 2768720	FlyBaseID:	FBgn0053503	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	127/517 - (24%)
Similarity:	238/517 - (46%)	Gaps:	56/517 - (10%)

- Green bases have known domain annotations that are detailed below.

Zfish    27 RSGRAPAIGLQD---STV----RPFNEIPGQWRNSLKSVFAFAKMGGLRNIHRIMVHNFNT---- 80
            ||.|:.::...:   |::    :.::|||..  |..|.:.||...|..:|   ..:..:.:
  Fly    18 RSSRSASVLAHEQAKSSITEEHKTYDEIPRP--NKFKFMRAFMPGGEFQN---ASITEYTSAMRK 77

Zfish    81 -FGPIY--REKVGFYESVNIIKPEDAAILFKAEGHYPKRLTIDAWTAYRDY-RNRKY----GVLL 137
             :|.||  ....|..:.|.....:|..::|:.||.:|:|..:|:...:|:: |...|    |::.
  Fly    78 RYGDIYVMPGMFGRKDWVTTFNTKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVA 142

Zfish   138 KDGEDWKSNRIILNKEVISPKVQGNFVPLLDEVGQDFVARVNKKIERSGQNQWTTDLSHELFKFA 202
            ...|.|...|..:|...:.|:....:...|..:..:|:.|: |:|......:...|.:.|:.:..
  Fly   143 SQNEAWGKLRSAINPIFMQPRGLRMYYEPLSNINNEFIERI-KEIRDPKTLEVPEDFTDEISRLV 206

Zfish   203 LESVSAVLYGERLGLLLDYIDPDSQRFIDCITLMFKTTSPM------LYLPPGLLRPIRSKIWRN 261
            .||:..|.:..::||:....|..     |.:|| |:|:..:      |.:.|.:.:.|.:..:|.
  Fly   207 FESLGLVAFDRQMGLIRKNRDNS-----DALTL-FQTSRDIFRLTFKLDIQPSMWKIISTPTYRK 265

Zfish   262 HVEAWDGIFNQADRCIQNIYRQLRKNPEGNGKYTGVLASLLMLDKLSIEDIKASV---TELMAGG 323
            .....:...|.:.:.::.....|.|..:...|    :.|..||::|...|.|.:|   .:::..|
  Fly   266 MKRTLNDSLNVSQKMLKENQDALEKRRQAGEK----INSNSMLERLMEIDPKVAVIMSLDILFAG 326

Zfish   324 VDTTAITLLWTLYELARNPDLQEEIRAEISAARIASKGDMV--QMLKMIPLVKGTLKETLRLHPV 386
            ||.||..|...|..|:::||.|.::|.|:.:. :.:|..::  :.:|.:|.::..:|||||.:|.
  Fly   327 VDATATLLSAVLLCLSKHPDKQAKLREELLSI-MPTKDSLLNEENMKDMPYLRAVIKETLRYYPN 390

Zfish   387 AVSLQRYITEDIVIQKYHIPAGTLVQLGLYAMGRDHQVFPNPEQYLPSRWVNS-------QNHYF 444
            .....|....|:::..|.:|.||.|.||...:.::...:|.|:::||.||:..       |...|
  Fly   391 GFGTMRTCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERWLRDPETGKKMQVSPF 455

Zfish   445 KSLSFGFGPRQCLGRRIAETEMQLFLIHMLENFRIEKQRQMEVKSMFELILLPEKPIMLTIK 506
            ..|.||||||.|:|:|:.:.||:..:..::.||.:|..|  :....|:.:.|.|..|....|
  Fly   456 TFLPFGFGPRMCIGKRVVDLEMETTVAKLIRNFHVEFNR--DASRPFKTMFLMEPAITFPFK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyp11a2	XP_021329545.1	p450	69..505	CDD:306555	114/465 (25%)
Cyp12d1-d	NP_995812.1	p450	70..508	CDD:299894	111/451 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2609
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820