Protein Alignment PRPS1 and CG2246

DIOPT Version :10

• Sequence 1: NP_002755.1
• Gene: PRPS1 / 5631
• HGNCID: 9462
• Length: 318
• Species: Homo sapiens
• Sequence 2: NP_733389.2
• Gene: CG2246 / 43637
• FlyBaseID: FBgn0039790
• Length: 406
• Species: Drosophila melanogaster
• Alignment Length: 378
• Identity: 154/378 - (40%)
• Similarity: 220/378 - (58%)
• Gaps: 63/378 - (16%)

Human     3 NIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNL 67
            :|.|.:|:||.||:..:|:|:|::.|.......||:||.|||.:||||:|:||:|:|..:.|:|:
  Fly    28 DIVIINGNSHPDLANMVAERMGIKNGGCSVFHKSNRETIVEISDSVRGKDIYIIQTGTKDANNNI 92

Human    68 MELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHAS 132
            ||||||..|||.:||..:..|||..||::|.|..| |..|.:||:|.|:..:|..||||||||..
  Fly    93 MELLIMAYACKTSSARSIVGVIPYLPYSKQCKMRK-RGCIVSKLLAKMMCTSGLTHIITMDLHQK 156

Human   133 QIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERK 197
            :||||||||||||.|.|.:|::|:|:|.::||..||:.:.|.||:..|.|:||.:..|:||.|:|
  Fly   157 EIQGFFDIPVDNLRASPFLLQYIQESIPDYRNSVIVARNPGVAKKANSYAERLRLGLAVIHGEQK 221

Human   198 K--ANEVD--------------------------------------------------------- 203
            :  |:|||
  Fly   222 ETDADEVDGRYSPPPTSAYSNLLGNSVEMCLPATPRNSTPQHAPTSSARQRTTSVSVGVPEHIVK 286

Human   204 ---RMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNAC 265
               .:.:||||..|:||:|||:.|.......||:.|...||.::|.:.|||:.|..|..:::.:.
  Fly   287 VKPPLTIVGDVSGRIAIMVDDLIDDVQAFVAAAEMLKENGACKIYVLATHGLLSSDAPRQLDESP 351

Human   266 FEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL 318
            .:.:|||||||.|.:...|.||:.||||:::||||||.||.||:||||.:|.|
  Fly   352 IDEIVVTNTIPHEIQKLQCHKIKTIDISILIAEAIRRIHNKESMSYLFRNVTL 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRPS1	NP_002755.1	PrsA	1..314	CDD:440230	151/372 (41%)
		Binding of phosphoribosylpyrophosphate. /evidence=ECO:0000255	212..227		7/14 (50%)
CG2246	NP_733389.2	Pribosyltran_N	29..144	CDD:433483	54/115 (47%)
		Pribosyl_synth	185..400	CDD:434046	70/214 (33%)